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CAPS Medical\u2122 PlasmaSure\u2122 is an innovative system that employs non-thermal atmospheric plasma in a minimally invasive procedure, and a first-in-human study has previously demonstrated its ability to safely and efficiently ablate superficial bladder tumors. The current case report shows that the same procedure can be conducted without the need for general anesthesia. These findings highlight a future potential for PlasmaSure\u2122 to enable in-office efficient ablation of superficial bladder tumors, thereby minimizing anesthesia-related risks and enhancing patient quality of life.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf863","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:12:15Z","timestamp":1760530335000},"source":"Crossref","is-referenced-by-count":0,"title":["Revolutionizing bladder tumor treatment with non-thermal atmospheric plasma treatment under local anesthesia: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Dolev","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Urology, Shaare Zedek Medical Center , PO B 3235, Jerusalem 91031 ,","place":["Israel"]},{"name":"Faculty of Medicine, The Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dothan","sequence":"additional","affiliation":[{"name":"Department of Urology, Shaare Zedek Medical Center , PO B 3235, Jerusalem 91031 ,","place":["Israel"]},{"name":"Faculty of Medicine, The Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Chertin","sequence":"additional","affiliation":[{"name":"Department of Urology, Shaare Zedek Medical Center , PO B 3235, Jerusalem 91031 ,","place":["Israel"]},{"name":"Faculty of Medicine, The Hebrew University , Jerusalem ,","place":["Israel"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"2025103115572696700_ref1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.euo.2022.10.003","article-title":"Epidemiology, screening, and prevention of bladder cancer","volume":"5","author":"Lobo","year":"2022","journal-title":"Eur Urol Oncol"},{"key":"2025103115572696700_ref2","volume-title":"EORTC Bladder Cancer Recurrence and Progression Calculator","author":"Bia\u0142ek","year":"2024"},{"key":"2025103115572696700_ref3","doi-asserted-by":"publisher","first-page":"100326","DOI":"10.1016\/j.jcpo.2022.100326","article-title":"Socio-economic burden of disease: survivorship costs for bladder cancer","volume":"32","author":"Michaeli","year":"2022","journal-title":"J Cancer Policy"},{"key":"2025103115572696700_ref4","article-title":"Quality of life in patients undergoing surveillance for non-muscle invasive bladder cancer\u2014a systematic review","volume":"10","author":"Nayak","year":"2021","journal-title":"TAU"},{"key":"2025103115572696700_ref5","doi-asserted-by":"publisher","first-page":"863","DOI":"10.5114\/aoms.2019.88430","article-title":"Prediction of the risk of surgical complications in patients undergoing monopolar transurethral resection of bladder tumour - a prospective multicentre observational study","volume":"16","author":"Poletajew","year":"2019","journal-title":"Arch Med Sci"},{"key":"2025103115572696700_ref6","first-page":"8198","article-title":"Short term complications from transurethral resection of bladder tumor","volume":"23","author":"Gregg","year":"2016","journal-title":"Can J Urol"},{"key":"2025103115572696700_ref7","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1002\/cncr.21765","article-title":"Risk factors for adverse outcomes after transurethral resection of bladder tumors","volume":"106","author":"Hollenbeck","year":"2006","journal-title":"Cancer"},{"key":"2025103115572696700_ref8","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/jcm10040893","article-title":"Cold atmospheric plasma: a new strategy based primarily on oxidative stress for osteosarcoma therapy","volume":"10","author":"Mateu-Sanz","year":"2021","journal-title":"J Clin Med"},{"key":"2025103115572696700_ref9","doi-asserted-by":"publisher","first-page":"1758835918786475","DOI":"10.1177\/1758835918786475","article-title":"Use of cold-atmospheric plasma in oncology: a concise systematic review","volume":"10","author":"Dubuc","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"2025103115572696700_ref10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.cpme.2013.08.001","article-title":"Plasma in cancer treatment","volume":"1","author":"Schlegel","year":"2013","journal-title":"Clin Plasma Med"},{"key":"2025103115572696700_ref11","volume-title":"Effects of Anesthesia. 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