{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T23:41:45Z","timestamp":1763077305974,"version":"3.45.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary esophageal sarcomas are exceedingly rare, with a subtype of pleomorphic rhabdomyosarcoma (PRMS) as exceptionally uncommon. We present the case of a healthy 58-year-old male with significant smoking history with 3 months of progressive dysphagia and 30\u00a0lb weight loss. Endoscopy revealed a large esophageal mass with biopsy demonstrating a high-grade malignant neoplasm with spindle cell features, favoring sarcoma. Staging workup confirmed a localized intraluminal tumor without distant metastasis. Given the progressive nature of the mass and near-complete obstruction, the patient underwent immediate esophagectomy. Final pathology demonstrated an 8.7\u00a0cm high grade PRMS involving the mucosa and submucosa without lymph node involvement, Stage IIIA (pT2N0M0), based on the American Joint Commission on Cancer (AJCC) criteria. This case underscores the importance of distinguishing sarcomas from esophageal carcinomas and recognizing early surgery as the cornerstone of management in localized PRMS given its limited responsiveness to chemoradiation.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf903","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T23:37:52Z","timestamp":1763077072000},"source":"Crossref","is-referenced-by-count":0,"title":["Esophageal pleomorphic rhabdomyosarcoma: a rare high-grade sarcoma managed with upfront resection"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3600-4141","authenticated-orcid":false,"given":"Jason","family":"Stanton","sequence":"first","affiliation":[{"name":"Department of Surgery, Geisinger Commonwealth School of Medicine , 525 Pine Street, Scranton, PA 18509,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salmaan","family":"Zafer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Geisinger Commonwealth School of Medicine , 525 Pine Street, Scranton, PA 18509,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Geisinger Wyoming Valley , 1000 East Mountain Boulevard, Wilkes Barre, PA 18711,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Cipriano","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Geisinger Community Medical Center , 1800 Mulberry Street, Scranton, PA 18510,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2025111318374767400_ref1","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/S0140-6736(12)60643-6","article-title":"Oesophageal carcinoma","volume":"381","author":"Pennathur","year":"2013","journal-title":"Lancet"},{"key":"2025111318374767400_ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/192423","article-title":"Rare cause of stricture esophagus\u2014sarcoma: a case report and review of the literature","volume":"2011","author":"Patricia","year":"2011","journal-title":"Case Rep Gastrointest Med"},{"key":"2025111318374767400_ref3","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/cncr.11550","article-title":"Rhabdomyosarcoma in adults: a retrospective analysis of 171 patients treated at a single institution","volume":"98","author":"Ferrari","year":"2003","journal-title":"Cancer"},{"key":"2025111318374767400_ref4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/cncr.10669","article-title":"Adult rhabdomyosarcoma: outcome following multimodality treatment","volume":"95","author":"Little","year":"2002","journal-title":"Cancer"},{"key":"2025111318374767400_ref5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1053\/j.semdp.2006.09.001","article-title":"Gastrointestinal stromal tumors: pathology and prognosis at different sites","volume":"23","author":"Miettinen","year":"2006","journal-title":"Semin Diagn Pathol"},{"key":"2025111318374767400_ref6","doi-asserted-by":"publisher","first-page":"1511957","DOI":"10.3389\/fonc.2025.1511957","article-title":"Case report and review of the literature: esophageal pleomorphic rhabdomyosarcoma","volume":"15","author":"Pittacolo","year":"2025","journal-title":"Front Oncol"},{"key":"2025111318374767400_ref7","doi-asserted-by":"publisher","first-page":"951433","DOI":"10.3389\/fonc.2022.951433","article-title":"Embryonic esophageal rhabdomyosarcoma in an adult male: a case report and literature review","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"2025111318374767400_ref8","volume-title":"AJCC Cancer Staging Manual","author":"Amin","year":"2017","edition":"8th"},{"key":"2025111318374767400_ref9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/1097-0142(20010215)91:4&lt;794::AID-CNCR1066&gt;3.0.CO;2-Q","article-title":"Clinicopathologic analysis of patients with adult rhabdomyosarcoma","volume":"91","author":"Hawkins","year":"2001","journal-title":"Cancer"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf903\/65286189\/rjaf903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf903\/65286189\/rjaf903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T23:37:53Z","timestamp":1763077073000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf903\/8322608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf903","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11,1]]},"article-number":"rjaf903"}}