{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T11:14:32Z","timestamp":1763896472703,"version":"3.45.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a case of a 73-year-old male with non-Hodgkin\u2019s lymphoma who underwent a restaging CT during treatment, which raised concern for a coexisting pathology. Consequently, a CT-guided biopsy was performed and a diagnosis of a second malignancy, an epithelioid haemangioendothelioma (EHE), was made. This is an exceptionally rare finding, given that the estimated incidence of EHE is only 0.4 cases per million per year. The patient has multifocal disease, with multiple pulmonary nodules and paravertebral\/intercostal masses. Treatment with pazopanib was initiated early on due to the patient\u2019s significant systemic symptoms and recurrent malignant pleural effusions (MPEs). Definitive pleural interventions, including talc pleurodesis and indwelling pleural catheter placement, were provided but were ultimately unsuccessful, and the effusion became loculated. The patient continues to suffer from extreme breathlessness. Given the significant impact on the quality of life of patients, this report delves into the complex management of MPEs in EHE.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf917","type":"journal-article","created":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T11:04:28Z","timestamp":1763895868000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of an incidentally discovered epithelioid haemangioendothelioma"],"prefix":"10.1093","volume":"2025","author":[{"given":"Sabrina B J","family":"Belfi","sequence":"first","affiliation":[{"name":"University of Nicosia Medical School , Makedonitissas Avenue, Nicosia CY-2417 ,","place":["Cyprus"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Bode-Lesniewska","sequence":"additional","affiliation":[{"name":"University of Zurich, R\u00e4mistrasse , Zurich 8006 ,","place":["Switzerland"]},{"name":"Lucerne Cantonal Hospital, Institute of Pathology , Spitalstrasse, Lucerne 6000 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhan","family":"Inci","sequence":"additional","affiliation":[{"name":"University of Nicosia Medical School , Makedonitissas Avenue, Nicosia CY-2417 ,","place":["Cyprus"]},{"name":"University of Zurich, R\u00e4mistrasse , Zurich 8006 ,","place":["Switzerland"]},{"name":"Klinik Hirslanden Zurich, Centre for Surgery Zurich, Thoracic Surgery , Witellikerstrasse, Zurich 8032 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"2025112306042199100_ref1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.esmoop.2021.100170","article-title":"Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts","volume":"6","author":"Stacchiotti","year":"2021","journal-title":"ESMO 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clinical trial","volume":"323","author":"Bhatnagar","year":"2020","journal-title":"JAMA"},{"key":"2025112306042199100_ref8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1136\/thorax-2022-219784","article-title":"British Thoracic Society guideline for pleural disease","volume":"78","author":"Roberts","year":"2023","journal-title":"Thorax"},{"key":"2025112306042199100_ref9","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.chest.2017.08.026","article-title":"Quality gaps and comparative effectiveness of management strategies for recurrent malignant pleural effusions","volume":"153","author":"Ost","year":"2018","journal-title":"Chest"},{"key":"2025112306042199100_ref10","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.2214\/ajr.175.6.1751545","article-title":"Epithelioid hemangioendothelioma of the pleura: clinical and radiologic features","volume":"175","author":"Crotty","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"2025112306042199100_ref11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7759\/cureus.41308","article-title":"Pleural epithelioid Hemangioendothelioma (EHE): a case report","author":"Pathak","year":"2023","journal-title":"Cureus"},{"key":"2025112306042199100_ref12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.critrevonc.2025.104749","article-title":"Intrapleural fibrinolytic therapy for loculated malignant pleural effusion: a systematic review and meta-analysis","volume":"211","author":"Takahashi","year":"2025","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025112306042199100_ref13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s13193-020-01099-2","article-title":"Hemorrhagic malignant pleural effusion: diagnosis, survival rate, and response to talc pleurodesis","volume":"12","author":"Lending","year":"2021","journal-title":"Indian J Surg Oncol"},{"key":"2025112306042199100_ref14","doi-asserted-by":"publisher","first-page":"O229","DOI":"10.1186\/1749-8090-8-S1-O229","article-title":"VATS decortication for trapped lung in malignant pleural effusion: results of surgery","volume":"8","author":"Minchev","year":"2013","journal-title":"J Cardiothorac Surg"}],"container-title":["Journal of Surgical Case 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