{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:31:33Z","timestamp":1792899093882,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucinous cystic neoplasms (MCNs) of the pancreas are rare mucin-producing epithelial tumors that predominantly affect middle-aged women and typically contain ovarian-type stroma responsive to hormonal stimulation. While progression and rupture of MCNs during pregnancy have been documented, the effects of exogenous hormonal stimulation remain uncertain. We present a unique case of a 39-year-old woman who experienced rapid cystic enlargement and rupture of a pancreatic MCN following hormonal therapy for in vitro fertilization (IVF). Imaging demonstrated progressive cyst growth with radiologic evidence of rupture, which was confirmed intraoperatively. Histopathological analysis revealed an MCN with low-grade dysplasia and immunohistochemical positivity for estrogen receptors. This case represents the first description of a potentially severe complication of gonadotropin stimulation in pancreatic MCNs and underscores the importance of screening for cystic pancreatic lesions in patients undergoing assisted reproductive therapies.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf923","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T15:10:44Z","timestamp":1763997044000},"source":"Crossref","is-referenced-by-count":1,"title":["Growth and rupture of pancreatic mucinous cystic neoplasm following hormonal stimulation for\n                    <i>in vitro<\/i>\n                    fertilization: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-4751","authenticated-orcid":false,"given":"Italo","family":"Sim\u00f5es","sequence":"first","affiliation":[{"name":"Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo - S\u00e3o Paulo, Hospital das Cl\u00ednicas HCFMUSP, Universidade de S\u00e3o Paulo , Av. Dr. En\u00e9as de Carvalho Aguiar, 255, Cerqueira Cesar, CEP 05403-900, Sao Paulo-SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela Regina Ramos","family":"Figueira","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo - S\u00e3o Paulo, Hospital das Cl\u00ednicas HCFMUSP, Universidade de S\u00e3o Paulo , Av. Dr. En\u00e9as de Carvalho Aguiar, 255, Cerqueira Cesar, CEP 05403-900, Sao Paulo-SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Rodrigo Francisco Martins","family":"Tavares","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo - S\u00e3o Paulo, Hospital das Cl\u00ednicas HCFMUSP, Universidade de S\u00e3o Paulo , Av. Dr. En\u00e9as de Carvalho Aguiar, 255, Cerqueira Cesar, CEP 05403-900, Sao Paulo-SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Garcia","family":"Marchiolli","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo - S\u00e3o Paulo, Hospital das Cl\u00ednicas HCFMUSP, Universidade de S\u00e3o Paulo , Av. Dr. En\u00e9as de Carvalho Aguiar, 255, Cerqueira Cesar, CEP 05403-900, Sao Paulo-SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Jukemura","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo - S\u00e3o Paulo, Hospital das Cl\u00ednicas HCFMUSP, Universidade de S\u00e3o Paulo , Av. Dr. En\u00e9as de Carvalho Aguiar, 255, Cerqueira Cesar, CEP 05403-900, Sao Paulo-SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"2025112410103713200_ref1","volume-title":"In vitro fertilization. In: StatPearls [Internet]. Treasure Island (FL)","author":"Choe","year":"2025"},{"key":"2025112410103713200_ref2","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1056\/NEJMcp065743","article-title":"In vitro fertilization","volume":"356","author":"Van Voorhis","year":"2007","journal-title":"N Engl J Med"},{"key":"2025112410103713200_ref3","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.pan.2016.09.011","article-title":"Nature and management of pancreatic mucinous cystic neoplasm: a systematic review","volume":"16","author":"Nilsson","year":"2016","journal-title":"Pancreatology."},{"key":"2025112410103713200_ref4","first-page":"300","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Zamboni","year":"2010","edition":"4th edn"},{"key":"2025112410103713200_ref5","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.pan.2024.04.009","article-title":"Implications of pregnancy on MCN of the pancreas: a multicentric case-control study","volume":"24","author":"Fogliati","year":"2024","journal-title":"Pancreatology"},{"key":"2025112410103713200_ref6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/00000478-199904000-00005","article-title":"Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors","volume":"23","author":"Zamboni","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"2025112410103713200_ref7","doi-asserted-by":"publisher","first-page":"e34820","DOI":"10.1097\/MD.0000000000034820","article-title":"A case report of a huge pancreatic mucinous cystic neoplasm during pregnancy","volume":"102","author":"Wang","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"2025112410103713200_ref8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/bjs.1800730727","article-title":"Cystadenocarcinoma of the pancreas presenting in pregnancy","volume":"73","author":"Smithers","year":"1986","journal-title":"Br J Surg"},{"key":"2025112410103713200_ref9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1053\/j.semdp.2014.08.007","article-title":"Mucinous cystic neoplasms of the pancreas: update on the surgical pathology and molecular genetics","volume":"31","author":"Fukushima","year":"2014","journal-title":"Semin Diagn Pathol"},{"key":"2025112410103713200_ref10","doi-asserted-by":"crossref","first-page":"P0099","DOI":"10.14309\/01.ajg.0000957496.45590.f3","article-title":"Growth of a mucinous cystic neoplasm during in vitro fertilization","volume":"118","author":"Zhou","year":"2023","journal-title":"Am J Gastroenterol"},{"key":"2025112410103713200_ref11","doi-asserted-by":"publisher","first-page":"S188","DOI":"10.1016\/j.fertnstert.2008.08.034","article-title":"Practice Committee of the American Society for Reproductive Medicine. Ovarian hyperstimulation syndrome","volume":"90","year":"2008","journal-title":"Fertil Steril"},{"key":"2025112410103713200_ref12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/IGC.0b013e318277608b","article-title":"Meta-analysis on the possible association between in vitro fertilization and cancer risk","volume":"23","author":"Li","year":"2013","journal-title":"Int J Gynecol Cancer"},{"key":"2025112410103713200_ref13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/MPA.0b013e3181f749d3","article-title":"Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: a multi-institutional study of the Japan pancreas society","volume":"40","author":"Yamao","year":"2011","journal-title":"Pancreas"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf923\/65491671\/rjaf923.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf923\/65491671\/rjaf923.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T15:10:45Z","timestamp":1763997045000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf923\/8341456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf923","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11,1]]},"article-number":"rjaf923"}}