{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:53:12Z","timestamp":1764093192565,"version":"3.45.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and sinus tracts, most often located in axillary, inguinal, and gluteal regions. Malignant transformation into squamous cell carcinoma is a rare but serious complication. We present the case of a 50-year-old man with \u02c310\u00a0years of poorly controlled hidradenitis suppurativa who developed painful gluteal discharge and multiple exophytic lesions. Imaging demonstrated large perianal and perineal masses with destruction of the coccyx, but no distant spread. Biopsy confirmed well-differentiated squamous cell carcinoma. Because of the local extent, the multidisciplinary team recommended radiotherapy as the primary treatment. Malignant degeneration of hidradenitis suppurativa is more frequent in long-standing, advanced disease, particularly in gluteal and perineal areas, and is associated with delayed diagnosis and high mortality. Early biopsy of suspicious lesions and multidisciplinary management are essential to improve prognosis.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf935","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:33:18Z","timestamp":1763382798000},"source":"Crossref","is-referenced-by-count":0,"title":["From chronic hidradenitis suppurativa to epidermoid carcinoma, from inflammation to cellular degeneration"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9215-6801","authenticated-orcid":false,"given":"Sa\u00fal","family":"S\u00e1nchez Iglesias","sequence":"first","affiliation":[{"name":"Hospital Universitario de Toledo , Avenida del R\u00edo Guadiana, Toledo 45007 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"de la Cruz Cuadrado","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Toledo , Avenida del R\u00edo Guadiana, Toledo 45007 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"de Pedro Conal","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Toledo , Avenida del R\u00edo Guadiana, Toledo 45007 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"2025112512493916400_ref1","doi-asserted-by":"publisher","first-page":"110271","DOI":"10.1016\/j.ijscr.2024.110271","article-title":"Squamous cell carcinoma arising in chronic hidradenitis suppurativa: a case report and comprehensive literature review","volume":"123","author":"Filho","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"2025112512493916400_ref2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.5114\/ada.2023.126563","article-title":"Hidradenitis suppurativa and squamous cell carcinoma: a systematic review of the literature","volume":"40","author":"Gierek","year":"2023","journal-title":"Postepy Dermatol Alergol"},{"key":"2025112512493916400_ref3","doi-asserted-by":"publisher","first-page":"2382372","DOI":"10.1080\/07853890.2024.2382372","article-title":"A state-of-the-art systematic review of cancer in hidradenitis suppurativa","volume":"56","author":"Abu Rached","year":"2024","journal-title":"Ann Med"},{"key":"2025112512493916400_ref4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/ccr3.2608","article-title":"Fatal outcome of malignant transformation of hidradenitis suppurativa: a case report and literature review","volume":"8","author":"Nielsen","year":"2020","journal-title":"Clin Case Rep"},{"key":"2025112512493916400_ref5","doi-asserted-by":"publisher","first-page":"1336688","DOI":"10.3389\/fmed.2024.1336688","article-title":"Multiple verrucous squamous cell carcinomas developing on chronic hidradenitis suppurativa lesions\u2014a rare case report from Romania","volume":"11","author":"Fekete","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"2025112512493916400_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjad459","article-title":"A late presentation of inguinoscrotal cutaneous squamous cell carcinoma (cSCC) masquerading as hidradenitis suppurativa-a case report","volume":"2023","author":"Lahham","year":"2023","journal-title":"J Surg Case Rep"},{"key":"2025112512493916400_ref7","doi-asserted-by":"publisher","first-page":"702","DOI":"10.3390\/cancers17040702","article-title":"HPV-16-induced squamous cell carcinoma in hidradenitis suppurativa: HPV vaccination may be useful","volume":"17","author":"Abu Rached","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2025112512493916400_ref8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000525347","article-title":"Advanced squamous cell carcinoma developed on chronic hidradenitis suppurativa, successfully treated with Cemiplimab: a case report","volume":"15","author":"Ruggiero","year":"2023","journal-title":"Case Rep Dermatol"},{"key":"2025112512493916400_ref9","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s13555-025-01457-4","article-title":"Management of hidradenitis suppurativa in special populations: a narrative review","volume":"15","author":"Mallela","year":"2025","journal-title":"Dermatol Ther (Heidelb)"}],"container-title":["Journal of Surgical Case 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