{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:44:57Z","timestamp":1790876697274,"version":"4.1.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Given the documented increased risk of non-arteritic ischaemic optic neuropathy (NAION), the widespread use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has raised concerns regarding their ophthalmic safety. This study presents a unique case of inflammatory optic neuritis and scleritis in a 43-year-old female one month following commencement of semaglutide. Extensive investigations for underlying systemic causes, including autoimmune and connective tissue disorders were negative. Treatment with systemic corticosteroids led to a gradual resolution of symptoms and return of vision to baseline over a three-month period. This case highlights a potential link between semaglutide and inflammatory ocular conditions. Clinicians should maintain an open mind when evaluating optic neuropathies in the context of GLP-1 RA use and consider corticosteroid-responsive inflammatory aetiologies as alternatives to NAION. Multicentre population-based cohort studies are warranted to determine whether a true association exists and to elucidate the potential mechanisms underlying semaglutide-associated ocular inflammation.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf937","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:09:32Z","timestamp":1762520972000},"source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory optic neuritis and scleritis following commencement of semaglutide: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Clare B","family":"Maher","sequence":"first","affiliation":[{"name":"Ophthalmology Department, John Hunter Hospital (Hunter New England Local Health District) , Lookout Road, New Lambton Heights, NSW 2305 ,","place":["Australia"]},{"name":"The University of Wollongong, Intelligent Polymer Research Institute , Northfields Avenue, Wollogong, NSW 2522 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Guo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, John Hunter Hospital (Hunter New England Local Health District) , Lookout Road, New Lambton Heights, NSW 2305 ,","place":["Australia"]},{"name":"Department of Medicine, University of Adelaide , 4 North Terrace, Adelaide, SA 5009 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony A","family":"Dunlop","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, John Hunter Hospital (Hunter New England Local Health District) , Lookout Road, New Lambton Heights, NSW 2305 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"2025112512494183300_ref1","doi-asserted-by":"crossref","first-page":"e000705","DOI":"10.1136\/bmjdrc-2019-000705","article-title":"Once-weekly semaglutide for patients with type 2 diabetes: a cost-effectiveness analysis in the Netherlands","volume":"7","author":"Hunt","year":"2019","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2025112512494183300_ref2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/jamaophthalmol.2024.2296","article-title":"Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide","volume":"142","author":"Hathaway","year":"2024","journal-title":"JAMA Ophthalmology"},{"key":"2025112512494183300_ref3","first-page":"e43773","article-title":"Acute pancreatitis in a patient taking semaglutide","volume":"15","author":"Patel","year":"2023","journal-title":"Cureus."},{"key":"2025112512494183300_ref4","doi-asserted-by":"crossref","first-page":"108255","DOI":"10.1016\/j.jdiacomp.2022.108255","article-title":"Progression of retinopathy with glucagon-like peptide-1 receptor agonists with cardiovascular benefits in type 2 diabetes \u2013 a systematic review and meta-analysis","volume":"36","author":"Yoshida","year":"2022","journal-title":"J Diabetes Complications"},{"key":"2025112512494183300_ref5","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101737","article-title":"Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials","volume":"55","author":"Verma","year":"2023","journal-title":"eClinicalMedicine"},{"key":"2025112512494183300_ref6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/CRD.0000000000000351","article-title":"Semaglutide: a novel oral glucagon-like peptide receptor agonist for the treatment of type 2 diabetes mellitus","volume":"29","author":"Chan","year":"2021","journal-title":"Cardiol Rev"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf937\/65500971\/rjaf937.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2025\/11\/rjaf937\/65500971\/rjaf937.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:49:49Z","timestamp":1764092989000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf937\/8342525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf937","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11,1]]},"article-number":"rjaf937"}}