{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:39:11Z","timestamp":1790102351042,"version":"4.0.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a case of malignant transformation in a young woman with pilonidal disease\u2014a rare manifestation of \u2018Marjolin\u2019s ulcer\u2019. The patient initially presented to an outside hospital emergency department with an ulcer of the left buttock. Her family reported a longstanding mass present at this site prior to rupture. The patient had two ED visits and a surgical referral that did not result in biopsy, contributing to delayed diagnosis. She eventually presented to our wound clinic with a full-thickness, friable, frond-like ulcer with probable sacral extension. Immediate biopsy was performed and confirmed squamous cell carcinoma (SCC). Imaging revealed a buttock mass with lymphadenopathy. Fine-needle aspiration confirmed metastatic SCC in the inguinal lymph nodes. The disease was deemed unresectable and systemic therapy was begun. This case emphasizes the importance of biopsy in nonhealing ulcers, underscores the need for system-level processes to ensure follow-up, and demonstrates the enduring relevance of Marjolin\u2019s original 19th-century observations.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf964","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:11:58Z","timestamp":1765372318000},"source":"Crossref","is-referenced-by-count":1,"title":["Marjolin\u2019s ulcer arising in pilonidal disease: a case report and historical perspective"],"prefix":"10.1093","volume":"2026","author":[{"given":"Paige","family":"Curcio","sequence":"first","affiliation":[{"name":"NYU Grossman School of Medicine , 550 1st Ave, New York, NY 10016 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgery, NYU Grossman School of Medicine , 550 1st Ave, New York, NY 10016 ,","place":["United States"]},{"name":"Kimmel Hyperbaric and Advanced Wound Healing Center, NYU Langone Health , 240 E 38th St, New York, NY 10016 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"2025122809174123800_ref1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1684\/ejd.2009.0705","article-title":"Squamous cell carcinoma related to long standing pilonidal-disease","volume":"19","author":"Chatzis","year":"2009","journal-title":"Eur J Dermatol"},{"key":"2025122809174123800_ref2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/jso.27319","article-title":"Pilonidal sinus disease carcinoma: survival and recurrence analysis","volume":"128","author":"Safadi","year":"2023","journal-title":"J Surg Oncol"},{"key":"2025122809174123800_ref3","first-page":"46","article-title":"Ulc\u00e8re","volume":"21","author":"Marjolin","year":"1828","journal-title":"Dictionnaire de M\u00e9decine"},{"key":"2025122809174123800_ref4","doi-asserted-by":"publisher","first-page":"3S","DOI":"10.1016\/j.jvs.2014.04.049","article-title":"Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum","volume":"60","author":"O\u2019Donnell","year":"2014","journal-title":"J Vasc Surg"},{"key":"2025122809174123800_ref5","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1001\/archdermatol.2011.3362","article-title":"Malignancy and chronic leg ulcers: the value of systematic wound biopsies: a prospective, multicenter, cross-sectional study","volume":"148","author":"Senet","year":"2012","journal-title":"Arch Dermatol"},{"key":"2025122809174123800_ref6","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1365-2133.1995.tb02707.x","article-title":"Venous leg ulcers and squamous cell carcinoma a large-scale epidemiological study","volume":"133","author":"Baldursson","year":"1995","journal-title":"British Journal of Dermatology"},{"key":"2025122809174123800_ref7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/jdv.12550","article-title":"A prospective case-control study of non-healing wounds of the lower limbs - the value of biopsies for ulcerating carcinoma","volume":"29","author":"Gil","year":"2015","journal-title":"Journal of the European Academy of Dermatology and Venereology: JEADV"},{"key":"2025122809174123800_ref8","doi-asserted-by":"publisher","first-page":"1248894","DOI":"10.3389\/fmed.2023.1248894","article-title":"Treatment of metastatic squamous cell carcinoma arising in sacrococcygeal pilonidal sinus: a case report series","volume":"10","author":"Soria Rivas","year":"2023","journal-title":"Front Med"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjaf964\/66141004\/rjaf964.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjaf964\/66141004\/rjaf964.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T14:17:46Z","timestamp":1766931466000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf964\/8405833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf964","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,24]]},"article-number":"rjaf964"}}