{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T14:21:11Z","timestamp":1766931671707,"version":"3.48.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cryptogenic multifocal ulcerative stenosing enteritis (CMUSE) is a rare enteropathy of unknown aetiology and pathophysiology. It is characterized by chronic and recurrent ulceration and stenosis of the small intestine. We present the case of a 33\u00a0year old female who had multiple presentations to our hospital with symptoms of small bowel obstruction. Diagnostic laparoscopy revealed extensive serosal adhesions with mixed transmural inflammation. The mucosa was extensively ulcerated and the bowel wall was congested and haemorrhagic, with hypertrophy of the muscularis propria. Ileoscopy revealed multiple strictures. Following treatment with balloon dilatation and surgical resection, she responded to treatment with immunomodulators and has remained in remission. CMUSE is a rare but important differential of benign SI strictures. The mainstays of treatment are steroids, immunomodulators, balloon dilatations, and surgical resection. Treatment should be aimed at reducing steroid dependence and preserving small bowel length, resorting to surgical resection in cases of occluding strictures.<\/jats:p>","DOI":"10.1093\/jscr\/rjaf977","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T13:12:46Z","timestamp":1765372366000},"source":"Crossref","is-referenced-by-count":0,"title":["Cryptogenic multifocal ulcerative stenosing enteritis (CMUSE): a rare case and a review of the literature"],"prefix":"10.1093","volume":"2026","author":[{"given":"Lauren","family":"Hudson","sequence":"first","affiliation":[{"name":"Surgical Intern, University College Dublin, Midlands Regional Hospital Mullingar , Longford Rd, Robinstown (Levinge), Mullingar, Co. Westmeath, N91 W237 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Grayson","sequence":"additional","affiliation":[{"name":"Surgical Registrar, Royal College of Surgeons Ireland, Midlands Regional Hospital Mullingar , Longford Rd, Robinstown (Levinge), Mullingar, Co. Westmeath, N91 W237 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"Toomey","sequence":"additional","affiliation":[{"name":"Consultant in General and Colorectal Surgery, Royal College of Surgeons Ireland, Midlands Regional Hospital Mullingar , Longford Rd, Robinstown (Levinge), Mullingar, Co. Westmeath, N91 W237 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"2025122809174131700_ref1","doi-asserted-by":"publisher","first-page":"e7527","DOI":"10.1097\/MD.0000000000007527","article-title":"Case report of a pair of siblings with cryptogenic multifocal ulcerating stenosing enteritis: a rare disease easily to be misdiagnosed as Crohn disease","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"2025122809174131700_ref2","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1111\/ans.17489","article-title":"Cryptogenic multifocal ulcerous stenosing enteritis: a difficult diagnosis","volume":"92","author":"Lew","year":"2022","journal-title":"ANZ J Surg"},{"key":"2025122809174131700_ref3","first-page":"193","article-title":"Cryptogenic plurifocal ulcerative stenosing enteritis","volume":"53","author":"Debray","year":"1964","journal-title":"Arch Mal Appar Dig Mal Nutr"},{"key":"2025122809174131700_ref4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.14712\/18059694.2016.59","article-title":"Severe cryptogenic multifocal ulcerous stenosing enteritis. A report of three cases and review of the literature","volume":"53","author":"Kohoutov\u00e1","year":"2010","journal-title":"Acta Med"},{"key":"2025122809174131700_ref5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/gut.48.3.333","article-title":"Cryptogenetic multifocal ulcerous stenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis","volume":"48","author":"Perlemuter","year":"2001","journal-title":"Gut"},{"key":"2025122809174131700_ref6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/gutjnl-2012-303581","article-title":"Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-alpha","volume":"63","author":"Brooke","year":"2014","journal-title":"Gut"},{"key":"2025122809174131700_ref7","doi-asserted-by":"publisher","first-page":"1005581","DOI":"10.1371\/journal.pgen.1005581","article-title":"A hereditary enteropathy caused by mutations in the SLCO2A1 gene, encoding a prostaglandin transporter","volume":"11","author":"Umeno","year":"2015","journal-title":"PLoS Genet"},{"key":"2025122809174131700_ref8","doi-asserted-by":"publisher","first-page":"9442181","DOI":"10.12659\/AJCR.944218","article-title":"Cryptogenic multifocal ulcerating Stenosing enteropathy: a rare case of small bowel stenosis","volume":"25","author":"Peng","year":"2024","journal-title":"Am J Case Rep"},{"key":"2025122809174131700_ref9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.51821\/85.3.9471","article-title":"Cryptogenic multifocal ulcerative stenosing enteritis (CMUSE) diagnosed by retrograde motorized spiral enteroscopy","volume":"85","author":"Belhassine","year":"2022","journal-title":"Acta Gastroenterol Belg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjaf977\/66141010\/rjaf977.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjaf977\/66141010\/rjaf977.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T14:17:50Z","timestamp":1766931470000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjaf977\/8405834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjaf977","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,24]]},"article-number":"rjaf977"}}