{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:27:43Z","timestamp":1772213263396,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The patient presented to the emergency department with nausea and vomiting with a large, rapidly growing soft tissue mass on her left shoulder diagnosed as a giant pilomatricoma. Pilomatricomas are tumours derived from hair follicles that are typically benign and rarely cause systemic symptoms. However, this patient exhibited hypercalcemia and elevated parathyroid hormone-related peptide (PTHrP) levels, suggesting PTHrP secretion by the tumour. Surgical resection normalized the patient's calcium and PTHrP levels. This case demonstrates that tumours such as pilomatricomas can rarely secrete PTHrP and cause hypercalcemia, a characteristic not typically associated with benign growths. It emphasizes the importance of considering benign tumours in the differential diagnosis of hypercalcemia.<\/jats:p>","DOI":"10.1093\/jscr\/rjag001","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:43:19Z","timestamp":1772109799000},"source":"Crossref","is-referenced-by-count":0,"title":["Benign giant pilomatricoma with associated hypercalcemia: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Colton","family":"Cox","sequence":"first","affiliation":[{"name":"MD Program, University of Nevada Reno School of Medicine , 1664 North Virginia Street, Reno, NV 89557 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyren","family":"Maynard","sequence":"additional","affiliation":[{"name":"MD Program, University of Nevada Reno School of Medicine , 1664 North Virginia Street, Reno, NV 89557 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babe","family":"Westlake D O","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Renown Health , 1155 Mill Street, Reno, NV 89502 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2026022711504933500_ref1"},{"key":"2026022711504933500_ref2","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1016\/j.asjsur.2022.12.029","article-title":"Pilomatricoma in the right parotid region: a case report and review of the literature","volume":"46","author":"Dang","year":"2023","journal-title":"Asian J Surg"},{"key":"2026022711504933500_ref3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1365-2133.2006.07286.x","article-title":"Giant pilomatricoma associated with hypercalcaemia and elevated levels of parathyroid hormone-related protein","volume":"155","author":"Kambe","year":"2006","journal-title":"Br J Dermatol"},{"key":"2026022711504933500_ref4","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s00467-010-1728-2","article-title":"Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma","volume":"26","author":"Srivastava","year":"2011","journal-title":"Pediatr Nephrol"},{"key":"2026022711504933500_ref5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ygyno.2004.01.013","article-title":"Hypercalcemia associated with a uterine leiomyoma: a case report and review of the literature","volume":"93","author":"Bilici","year":"2004","journal-title":"Gynecol Oncol"},{"key":"2026022711504933500_ref6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/MAJ.0b013e3181520125","article-title":"Humoral hypercalcemia of benignancy secondary to parathyroid hormone-related protein secreting uterine leiomyoma","volume":"335","author":"Dagdelen","year":"2008","journal-title":"Am J Med Sci"},{"key":"2026022711504933500_ref7","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1210\/jcem-70-6-1559","article-title":"A case of pheochromocytoma producing parathyroid hormone-related protein and presenting with hypercalcemia","volume":"70","author":"Kimura","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"2026022711504933500_ref8"},{"key":"2026022711504933500_ref9","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jama.2022.18331","article-title":"Hypercalcemia: a review","volume":"328","author":"Walker","year":"2022","journal-title":"JAMA"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/2\/rjag001\/67156905\/rjag001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/2\/rjag001\/67156905\/rjag001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:50:56Z","timestamp":1772211056000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag001\/8501305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag001","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,31]]},"article-number":"rjag001"}}