{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:41:43Z","timestamp":1770194503867,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Deep fibrous histiocytoma (DFH), also termed deep benign fibrous histiocytoma, is an uncommon fibroblastic neoplasm that typically arises in the dermis or subcutis. Occurrence in deep soft tissues is rare and retroperitoneal presentation is exceptional. Distinguishing DFH from soft tissue sarcomas can be challenging when lesions show atypical morphology or focal lipogenic change. We report a giant retroperitoneal DFH displaying low-grade myxoid and dedifferentiated liposarcoma-like area and summarize diagnostic pearls and management considerations. A 53-year-old man presented with postprandial dyspepsia and increased bowel movements. Imaging revealed a multilobulated retroperitoneal mass (35\u2009\u00d7\u200932\u2009\u00d7\u200918\u00a0cm) displacing the inferior vena cava, aorta, and bowel loops, with the left kidney ectopically located in the right paramedian pelvis. Through a xipho-pubic laparotomy, a well-encapsulated 12-kg tumor was excised en bloc without rupture. Histology showed a spindle-cell proliferation with storiform and meningothelial-like architecture consistent with DFH, with foci of low-grade myxoid change and areas mimicking dedifferentiated liposarcoma. Immunohistochemistry demonstrated CD34 positivity and negativity for S100 and smooth muscle actin in the fibrohistiocytic component. The early postoperative course was uneventful. Retroperitoneal DFH is a diagnostic mimic of liposarcoma and other sarcomas. Correlation of morphology with an appropriate immunophenotype and clinical-radiologic context is essential to avoid overtreatment. Complete surgical excision is the mainstay of therapy; long-term surveillance is advisable given the deep location and size.<\/jats:p>","DOI":"10.1093\/jscr\/rjag015","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:41:08Z","timestamp":1767789668000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare case of deep fibrous histiocytoma with low-grade myxoid and dedifferentiated liposarcoma features: clinical, radiological, and histopathological insights"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-6638","authenticated-orcid":false,"given":"Alessandro","family":"Verbo","sequence":"first","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore , Largo Francesco Vito 1, 00168 Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia Angelo","family":"Bez","sequence":"additional","affiliation":[{"name":"Mater Olbia Hospital , Via Giuseppe Bazzoni, 07026 Olbia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Mater Olbia Hospital , Via Giuseppe Bazzoni, 07026 Olbia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Verbo","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , Piazzale Aldo Moro 5, 00185 Rome ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026012712402759800_ref1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO classification of soft tissue tumours: news and perspectives","volume":"113","author":"Sbaraglia","year":"2021","journal-title":"Pathologica"},{"key":"2026012712402759800_ref2","doi-asserted-by":"publisher","first-page":"687","DOI":"10.5858\/arpa.2020-0771-RA","article-title":"Updates from the 2020 World Health Organization classification of soft tissue and bone tumours","volume":"145","author":"Anderson","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"2026012712402759800_ref3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s13018-023-03858-0","article-title":"Deep fibrous histiocytoma of the index finger: a case report","volume":"18","author":"Shibayama","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"2026012712402759800_ref4","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3390\/cancers14030536","article-title":"Retroperitoneal sarcoma care in 2021","volume":"14","author":"Schmitz","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026012712402759800_ref5","volume-title":"WHO Classification of Tumours of Soft Tissue (5th edition overview)","author":"Radiopaedia.org"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag015\/66591815\/rjag015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag015\/66591815\/rjag015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:40:31Z","timestamp":1769535631000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag015\/8442435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag015","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,24]]},"article-number":"rjag015"}}