{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:29:27Z","timestamp":1770697767418,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pancreatic acinar cell carcinoma (PACC) is a rare malignancy accounting for 0.2%\u20134.3% of pancreatic tumours, typically affecting older men. Cystic variants are exceptionally uncommon and often mimic benign pancreatic lesions, posing diagnostic challenges. We report a 37-year-old woman who was incidentally found to have a large multiseptated lesion involving the pancreas, spleen, and retroperitoneal structures. Surgical exploration demonstrated multiple peritoneal and hepatic nodules. Distal pancreatectomy, splenectomy, omentectomy, and resection of hepatic lesions were performed. Histopathology confirmed poorly differentiated pancreatic acinar cell carcinoma with extensive peritoneal metastases. Postoperative recovery was uneventful. This case highlights a rare cystic presentation of PACC in an atypical demographic. Clinicians should maintain a high index of suspicion for rare pancreatic malignancies in the differential diagnosis of complex cystic abdominal lesions.<\/jats:p>","DOI":"10.1093\/jscr\/rjag027","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:34:18Z","timestamp":1768307658000},"source":"Crossref","is-referenced-by-count":0,"title":["Multinodular cystic pancreatic acinar cell carcinoma presenting as a splenic hilum cyst with peritoneal carcinomatosis: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Mohammad Kheir","family":"Chahine","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Hamou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dima E","family":"Hajj","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layan","family":"Ghraizi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ribal","family":"Houmani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-2424","authenticated-orcid":false,"given":"Ghassan","family":"Nabbout","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand , PO Box 100, Al-Koura, Tripoli ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Wakim","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Mount Lebanon Hospital , Michel Gharios Street, PO BOX 470- Beirut ,","place":["Lebanon"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026013008452277300_ref1","doi-asserted-by":"publisher","author":"","DOI":"10.1093\/jjco\/hyad176"},{"key":"2026013008452277300_ref2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/MPA.0000000000001788","article-title":"Survival outcomes of acinar cell pancreatic cancer: a National Cancer Database Analysis","volume":"50","author":"Shaib","year":"2021","journal-title":"Pancreas."},{"key":"2026013008452277300_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.860740","article-title":"Cystic neoplasms of the pancreas: differential diagnosis and radiology correlation","volume":"12","author":"Hu","year":"2022","journal-title":"Front Oncol"},{"key":"2026013008452277300_ref4","doi-asserted-by":"publisher","first-page":"808","DOI":"10.5858\/arpa.2019-0472-RA","article-title":"Pancreatic neoplasms with acinar differentiation: a review of pathologic and molecular features","volume":"144","author":"Thompson","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"2026013008452277300_ref5","doi-asserted-by":"publisher","author":"","DOI":"10.1177\/1073274820969447"},{"key":"2026013008452277300_ref6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/jjco\/hyad176","article-title":"Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment","volume":"54","author":"Ikezawa","year":"2024","journal-title":"Jpn J Clin Oncol"},{"key":"2026013008452277300_ref7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s12029-025-01233-9","article-title":"Pancreatic acinar cell carcinoma: demographics, treatment, and survival outcomes, a retrospective population-based study","volume":"56","author":"Yasinzai","year":"2025","journal-title":"J Gastrointest Cancer"},{"key":"2026013008452277300_ref8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40644-025-00859-z","article-title":"Acinar cell carcinoma of the pancreas: can CT and MR features predict survival?","volume":"25","author":"Cheng","year":"2025","journal-title":"Cancer Imaging"},{"key":"2026013008452277300_ref9","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1245\/s10434-024-16331-4","article-title":"Survival outcomes and genetic characteristics of resected pancreatic acinar cell carcinoma","volume":"32","author":"Blair","year":"2025","journal-title":"Ann Surg Oncol"},{"key":"2026013008452277300_ref10","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1186\/s12885-018-5008-z","article-title":"Pancreatic acinar cell carcinoma\u2014case report and literature review","volume":"18","author":"Xing-mao","year":"2018","journal-title":"BMC Cancer"},{"key":"2026013008452277300_ref11","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1002\/jso.27834","article-title":"The role of chemotherapy in the management of pancreatic acinar cell carcinoma","volume":"130","author":"Woo","year":"2024","journal-title":"J Surg Oncol"},{"key":"2026013008452277300_ref12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40792-023-01729-1","article-title":"A resected case of acinar cell carcinoma of the pancreas with liver metastasis following chemotherapy using modified FOLFIRINOX","volume":"9","author":"Yamada","year":"2023","journal-title":"Surg Case Rep"},{"key":"2026013008452277300_ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1210064","article-title":"New treatment insights into pancreatic acinar cell carcinoma: case report and literature review.","volume":"13","author":"Zhao","year":"2023","journal-title":"Front Oncol"},{"key":"2026013008452277300_ref14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13045-024-01613-x","article-title":"Consensus, debate, and prospective on pancreatic cancer treatments","volume":"17","author":"Wang","year":"2024","journal-title":"J Hematol Oncol"},{"key":"2026013008452277300_ref15","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3390\/jcm14041129","article-title":"Current and emerging treatment options for pancreatic cancer: a comprehensive review","volume":"14","author":"Hayat","year":"2025","journal-title":"J Clin Med"},{"key":"2026013008452277300_ref16","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.annonc.2023.08.009","article-title":"Pancreatic cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"34","author":"Conroy","year":"2023","journal-title":"Ann Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag027\/66641116\/rjag027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag027\/66641116\/rjag027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:45:28Z","timestamp":1769780728000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag027\/8445458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag027","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,24]]},"article-number":"rjag027"}}