{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:38:34Z","timestamp":1769863114172,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":37,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast sarcomas are rare malignancies, accounting for &amp;lt;1% of all breast malignancies and &amp;lt;5% of all soft tissue sarcomas. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that arise from peripheral nerves. Their occurrence in the breast is exceedingly rare. This is the fourth published case of mammary MPNST in a male patient. We present a case of a 93-year-old male with a three-year history of a progressively enlarging and painful right breast mass. Examination revealed a 20\u2009\u00d7\u200930\u00a0cm immobile, fungating, and ulcerating mass with purulent discharge. Histopathological assessment confirmed a high-grade spindle cell sarcoma, and immunohistochemistry revealed positivity for vimentin, S100 protein, and p63 in a focal pattern, confirming the diagnosis of MPNST. The patient underwent a right mastectomy, achieving a surgical clearance. After 3\u00a0months, he passed away with malignant pleural effusion due to lung metastasis.<\/jats:p>","DOI":"10.1093\/jscr\/rjag029","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T12:31:43Z","timestamp":1768653103000},"source":"Crossref","is-referenced-by-count":0,"title":["Mammary malignant peripheral nerve sheath tumor in a 93-year-old male: case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Badria Eid","family":"Aljohani","sequence":"first","affiliation":[{"name":"Consultant Breast Oncology Surgery, Breast Center of Excellence, King Salman Bin Abdulaziz Medical City , Medina ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duaa Salem","family":"Alkhayat","sequence":"additional","affiliation":[{"name":"Consultant Medical Oncology, King Salman Bin Abdulaziz Medical City , Medina ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5350-2834","authenticated-orcid":false,"given":"Rouz Faisal","family":"Abu Sulami","sequence":"additional","affiliation":[{"name":"Medical Intern, College of Medicine, Taibah University , Medina ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Khalid","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Medical Intern, College of Medicine, Taibah University , Medina ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026013008461857800_ref1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10549-010-0915-y","article-title":"Diagnosis and management of primary breast sarcoma","volume":"122","author":"Al-Benna","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"2026013008461857800_ref2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13256-017-1332-1","article-title":"Unusual primary breast cancer - malignant peripheral nerve sheath tumor: a case report and review of the literature","volume":"11","author":"Shuayb","year":"2017","journal-title":"J Med Case Reports"},{"key":"2026013008461857800_ref3","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s13193-015-0388-x","article-title":"Malignant peripheral nerve sheath tumour of the male breast with nodal metastasis","volume":"6","author":"Suganya","year":"2015","journal-title":"Indian J Surg Oncol"},{"key":"2026013008461857800_ref4","doi-asserted-by":"publisher","first-page":"71161","DOI":"10.24941\/ijcr.31311.07.2018","article-title":"Case of malignant peripheral nerve sheath tumor (MPNST) of breast in a male patient: a very rare case report","volume":"10","author":"Kania","year":"2018","journal-title":"Int J Curr Res"},{"key":"2026013008461857800_ref5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000229548","article-title":"Melanocytic malignant peripheral nerve sheath tumor of the male breast","volume":"4","author":"Wang","year":"2009","journal-title":"Breast Care (Basel)"},{"key":"2026013008461857800_ref6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1590\/0100-3984.2016.0141","article-title":"Sarcomas of the breast: findings on mammography, ultrasound, and magnetic resonance imaging","volume":"51","author":"Matsumoto","year":"2018","journal-title":"Radiol Bras"},{"key":"2026013008461857800_ref7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/978-3-319-57726-5","volume-title":"Diagnosis and Management of Breast Tumors","author":"Idowu","year":"2017","edition":"1st"},{"key":"2026013008461857800_ref8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000523811","article-title":"Peripheral neural sheath breast sarcoma: case report and literature review","volume":"15","author":"Forero","year":"2022","journal-title":"Case Rep Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag029\/66641193\/rjag029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/1\/rjag029\/66641193\/rjag029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:46:22Z","timestamp":1769780782000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag029\/8445466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag029","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,12,24]]},"article-number":"rjag029"}}