{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T19:35:49Z","timestamp":1770924949780,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spinal epidural lipomatosis (SEL) is a rare cause of lumbar canal stenosis, typically linked to obesity or corticosteroid use. Severe cases often require decompression. We report a 48-year-old man with chronic low back pain and morbid obesity (153\u00a0kg) who presented with extensive SEL and critical stenosis. Previous conservative therapies failed. A non-surgical strategy using GLP-1\u2013induced weight loss (semaglutide) and medical cannabis for pain control was initiated. Over a follow-up of one year, his weight dropped to 93.8\u00a0kg, with major improvement in pain and mobility. MRI demonstrated near-complete regression of epidural fat and resolution of stenosis, avoiding surgery. The patient remained neurologically intact. This appears to be the first documented case of SEL reversal achieved through medical weight loss alone. The findings highlight GLP-1 agonists as a potential therapeutic option in obesity-related spinal disorders and support cannabis as part of non-opioid pain management.<\/jats:p>","DOI":"10.1093\/jscr\/rjag052","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:40:11Z","timestamp":1768999211000},"source":"Crossref","is-referenced-by-count":0,"title":["Complete radiologic and clinical reversal of lumbar spinal epidural lipomatosis via GLP-1 agonist"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2111-4780","authenticated-orcid":false,"given":"Lennard M","family":"Wurm","sequence":"first","affiliation":[{"name":"Department of Traumatology and Reconstructive Surgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health , Berlin ,","place":["Germany"]},{"name":"Medical Faculty Heinrich-Heine University and University Hospital D\u00fcsseldorf , D\u00fcsseldorf ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Private Practice , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Ertel","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Reconstructive Surgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Laue","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Reconstructive Surgery, Charit\u00e9, Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin and Berlin Institute of Health , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"2026021213541464800_ref1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/2192568218793617","article-title":"Spinal epidural lipomatosis: a review of pathogenesis, characteristics, clinical presentation, and management","volume":"9","author":"Kim","year":"2019","journal-title":"Glob Spine J"},{"key":"2026021213541464800_ref2","doi-asserted-by":"publisher","DOI":"10.52965\/001c.33975","article-title":"Bilateral lower extremity weakness: spinal epidural lipomatosis or more?","volume":"14","author":"Krishnan","year":"2022","journal-title":"Orthop Rev"},{"key":"2026021213541464800_ref3","doi-asserted-by":"crossref","first-page":"rjae520","DOI":"10.1093\/jscr\/rjae520","article-title":"Pseudohypoxic brain swelling following cerebrospinal fluid leakage: a case report on 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