{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:54:55Z","timestamp":1777877695968,"version":"3.51.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paraneoplastic syndromes are indirect clinical manifestations of cancer, arising from immunological mechanisms or tumor-derived substances. The most common paraneoplastic syndromes associated with lung cancer are endocrine syndromes. We report the case of a 50- year-old woman with progressive ocular proptosis and orbital pain who was evaluated by multiple specialties with various diagnostic tests that did not explain her symptoms. She received immunosuppressive therapy without clinical improvement. A right paracardiac mass was subsequently identified on imaging, initially suspected to be a pericardial cyst, but prior studies over 3 years showed significant interval growth. The lesion was resected via thoracoscopic surgery, and the patient showed symptomatic improvement within a few days. Pathological results revealed a benign metastasizing leiomyoma. Given clinical presentation and postoperative evolution, a paraneoplastic mechanism is considered the most likely cause of the patient\u2019s ocular proptosis.<\/jats:p>","DOI":"10.1093\/jscr\/rjag081","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:56:18Z","timestamp":1777377378000},"source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic ocular proptosis secondary to a pulmonary benign metastasizing leiomyoma: a case report and brief literature review"],"prefix":"10.1093","volume":"2026","author":[{"given":"Mar\u00eda Alejandra","family":"Amaya","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidad del Bosque , Av. Cra. 9 No. 131 A - 02, Bogot\u00e1 111321 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C\u00e9sar Granada","family":"Camacho","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Fundaci\u00f3n Santa Fe de Bogot\u00e1 , Calle 119 # 7-75, Bogot\u00e1 110111 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Gerardo Garc\u00eda-Herreros","family":"Hellal","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, Fundaci\u00f3n Santa Fe de Bogot\u00e1 , Calle 119 # 7-75, Bogot\u00e1 110111 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0830-5044","authenticated-orcid":false,"given":"Juliana","family":"Pardo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes , Cra 1 N\u00ba 18A- 12, Bogot\u00e1 111711 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"2026043018590935100_ref1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220085","article-title":"Paraneoplastic syndromes from head to toe: pathophysiology, imaging features, and workup","volume":"43","author":"Badawy","year":"2023","journal-title":"Radiographics"},{"key":"2026043018590935100_ref2","doi-asserted-by":"publisher","first-page":"838","DOI":"10.4065\/mcp.2010.0099","article-title":"Paraneoplastic syndromes: an approach to diagnosis and treatment","volume":"85","author":"Pelosof","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"2026043018590935100_ref3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5306\/wjco.v5.i3.197","article-title":"Paraneoplastic syndromes associated with lung cancer. World","volume":"5","author":"Kanaji","year":"2014","journal-title":"J Clin Oncol"},{"key":"2026043018590935100_ref4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.21037\/atm.2019.04.86","article-title":"Paraneoplastic syndromes in lung cancer and their management","volume":"7","author":"Anwar","year":"2019","journal-title":"Ann Transl Med"},{"key":"2026043018590935100_ref5","doi-asserted-by":"publisher","first-page":"20180049","DOI":"10.1259\/bjrcr.20180049","article-title":"Bilateral extraocular muscle enlargement and proptosis associated with squamous cell carcinoma of the lung","volume":"5","author":"Kim","year":"2018","journal-title":"BJR Case Rep"},{"key":"2026043018590935100_ref6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.33588\/rn.4907.2009147","article-title":"Proptosis bilateral paraneopl\u00e1sica asociada a carcinoma de pulm\u00f3n","volume":"49","author":"Romano","year":"2009","journal-title":"Rev Neurol"},{"key":"2026043018590935100_ref7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1378\/chest.123.2.627","article-title":"Paraneoplastic bilateral proptosis in a case of non-small cell lung cancer","volume":"123","author":"Diacon","year":"2003","journal-title":"Chest"},{"key":"2026043018590935100_ref8","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1097\/IOP.0b013e3182078e31","article-title":"Extraocular muscle enlargement as a paraneoplastic effect of breast carcinoma in a male patient","volume":"27","author":"Mehta","year":"2011","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2026043018590935100_ref9","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2169\/internalmedicine.5286-20","article-title":"Pleomorphic carcinoma with exophthalmos and a subsequent diagnosis of paraneoplastic syndrome","volume":"60","author":"Kuzunishi","year":"2021","journal-title":"Intern Med"},{"key":"2026043018590935100_ref10","first-page":"168","article-title":"A case of squamous cell carcinoma of the lung associated with exophthalmos and hypercalcemia","volume":"51","author":"Fukushima","year":"1998","journal-title":"Kyobu Geka"},{"key":"2026043018590935100_ref11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.24875\/j.gamo.22000023","article-title":"Leiomioma metastatizante benigno: reporte de Caso","volume":"21","author":"Reyes-Esparza","year":"2022","journal-title":"Gaceta mexicana de oncolog\u00eda"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag081\/68198233\/rjag081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag081\/68198233\/rjag081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:59:18Z","timestamp":1777589958000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag081\/8666072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag081","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4,1]]},"article-number":"rjag081"}}