{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:49:48Z","timestamp":1793638188835,"version":"4.5.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pyogenic granuloma (PG) is a common reactive vascular hyperplasia of the oral cavity with multifactorial origin. Although benign, it shows clinical variability and may recur if predisposing factors persist. This report describes two oral PG cases with different etiologies. A 68-year-old man presented with a mucogingival lesion associated with dental calculus, while a 29-year-old woman developed a lesion during pregnancy that continued after delivery. Both were treated with complete surgical excision and elimination of local irritants. Histopathology confirmed PG, characterized by granulation tissue rich in vascular spaces, inflammatory infiltrate, and areas of epithelial ulceration. Follow-up visits showed good healing and no recurrence. These cases emphasize the interaction of local agents like calculus and biofilm with systemic factors such as gestational hormonal changes. PG management requires identifying contributing factors and performing thorough surgical removal, though alternative methods\u2014cryosurgery, electrosurgery, or laser\u2014may be useful in selected scenarios.<\/jats:p>","DOI":"10.1093\/jscr\/rjag100","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:47:49Z","timestamp":1770209269000},"source":"Crossref","is-referenced-by-count":5,"title":["Multifactorial etiology of oral pyogenic granuloma: case reports with distinct triggers"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5595-2881","authenticated-orcid":false,"given":"Francisco Javier","family":"Alcaraz-Baturoni","sequence":"first","affiliation":[{"name":"Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Sierra Mojada 950, Colonia Independencia Oriente, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7967-1411","authenticated-orcid":false,"given":"Jessica Paola","family":"Ibarra-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Sierra Mojada 950, Colonia Independencia Oriente, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-7969","authenticated-orcid":false,"given":"Mario Alberto","family":"Alarc\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Medicine Program, Molecular Biology Department, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG , Sierra Mojada 950, Colonia Independencia Oriente, Guadalajara 44340, Jalisco ,","place":["Mexico"]},{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Sierra Mojada 950, Colonia Independencia Oriente, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-3111","authenticated-orcid":false,"given":"Giselle Berenice","family":"Vela-Sancho","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroimmunobiology, Institute of Translational Neurosciences, Department of Molecular Biology and Genomics, University Center for Health Sciences, University of Guadalajara (CUCS-UdeG) , Sierra Mojada 950, Colonia Independencia Oriente, Guadalajara 44340, Jalisco, \u00a0","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Flores-Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Salamanca , Campus Miguel de Unamuno, 37008 Salamanca ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University , Chennai 600 077 ,","place":["India"]},{"name":"Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi , Str. Koryun 2, Yerevan 0025 ,","place":["Armenia"]},{"name":"Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences , North Karegar St, Tehran 1439955591 ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8947-2109","authenticated-orcid":false,"given":"Rocio Del Carmen","family":"Anaya-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center, University of Guadalajara (CUCIENEGA-UdeG) , Avenida Universidad 115, Colonia LindaVista, Ocotl\u00e1n 47810, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-1387","authenticated-orcid":false,"given":"Sarah Monserrat","family":"Lomel\u00ed-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center, University of Guadalajara (CUCIENEGA-UdeG) , Avenida Universidad 115, Colonia LindaVista, Ocotl\u00e1n 47810, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026022612155912200_ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/njms.NJMS_55_18","article-title":"Heterogeneous conceptualization of etiopathogenesis: oral pyogenic granuloma","volume":"10","author":"Sharma","year":"2019","journal-title":"Natl J Maxillofac Surg"},{"key":"2026022612155912200_ref2","doi-asserted-by":"crossref","first-page":"16885","DOI":"10.3390\/ijms242316885","article-title":"Oral pyogenic granuloma: a narrative review","volume":"24","author":"Lomeli Martinez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026022612155912200_ref3","doi-asserted-by":"crossref","first-page":"S999","DOI":"10.4103\/jpbs.jpbs_703_23","article-title":"Oral pyogenic granuloma at different spots: a series of case reports","volume":"16","author":"Phull","year":"2024","journal-title":"J Pharm Bioallied Sci"},{"key":"2026022612155912200_ref4","first-page":"e49326","article-title":"A persistent oral pyogenic granuloma: a case report with review of literature","volume":"15","author":"Alshuhail","year":"2023","journal-title":"Cureus"},{"key":"2026022612155912200_ref5","article-title":"An overview of oral pyogenic granuloma and its management: a case report","volume":"15","author":"Meshram","year":"2023","journal-title":"Cureus"},{"key":"2026022612155912200_ref6","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4103\/jisp.jisp_189_20","article-title":"Sclerotherapy - a novel modality in the management of oral pyogenic granuloma","volume":"25","author":"Soni","year":"2021","journal-title":"J Indian Soc Periodontol"},{"key":"2026022612155912200_ref7","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.15537\/smj.2016.12.15941","article-title":"Excision of oral pyogenic granuloma in a diabetic patient with 940nm diode laser","volume":"37","author":"Al-Mohaya","year":"2016","journal-title":"Saudi Med J"},{"key":"2026022612155912200_ref8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10266-022-00759-9","article-title":"Diode laser versus sclerotherapy: bloodless approaches in the treatment of oral pyogenic granuloma (randomised controlled clinical trial)","volume":"111","author":"Anwar","year":"2023","journal-title":"Odontology"},{"key":"2026022612155912200_ref9","first-page":"e84713","article-title":"Oral pyogenic granuloma in a child: suspected hormonal and traumatic factors, clinical features, and surgical management","volume":"17","author":"Daoudi","year":"2025","journal-title":"Cureus"},{"key":"2026022612155912200_ref10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/edt.12537","article-title":"Labial pyogenic granuloma related to trauma: a case report and mini-review","volume":"36","author":"Banjar","year":"2020","journal-title":"Dent Traumatol"},{"key":"2026022612155912200_ref11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jog.13150","article-title":"Systemic alterations and their oral manifestations in pregnant women","volume":"43","author":"Araujo","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"key":"2026022612155912200_ref12","doi-asserted-by":"crossref","first-page":"12688","DOI":"10.3390\/app132312688","article-title":"Peripheral giant cell granuloma in pregnancy: a case report","volume":"13","author":"Alcaraz Baturoni","year":"2023","journal-title":"Appl Sci"},{"key":"2026022612155912200_ref13","first-page":"168","article-title":"Trauma-induced Giant pyogenic granuloma in the upper lip","volume":"82","author":"Carvalho","year":"2015","journal-title":"J Dent Child (Chic)"},{"key":"2026022612155912200_ref14","first-page":"e42157","article-title":"Lobular capillary Hemangioma masquerading as pyogenic granuloma of anterior mandible: a case report","volume":"15","author":"Srinivedha","year":"2023","journal-title":"Cureus"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/2\/rjag100\/67138002\/rjag100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/2\/rjag100\/67138002\/rjag100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:16:07Z","timestamp":1772126167000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag100\/8499727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag100","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,1,31]]},"article-number":"rjag100"}}