{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:44:57Z","timestamp":1772937897621,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eccrine porocarcinoma (EPC) is a rare, aggressive skin cancer arising from eccrine sweat glands, comprising less than 0.01% of all skin cancers. Management is especially complex in immunosuppressed patients due to increased tumor aggressiveness, recurrence, and limited treatment options. We present a 69-year-old woman with recurrent facial EPC following liver and kidney transplantation for Wilson\u2019s disease and hepatitis C. Despite multiple surgeries and two courses of radiation, she experienced multifocal locoregional recurrence. Immunotherapy was contraindicated due to high graft rejection risk, and prior radiation limited options. Radical facial resection with orbital exenteration, bilateral neck dissection, and complex reconstruction using VRAM and pectoralis major flaps, scalp rotation, and skin grafting was undertaken. This case highlights the challenges of treating EPC in immunosuppressed patients and underscores the need for a multidisciplinary approach. While surgery remains the cornerstone of treatment, novel therapies including immune checkpoint inhibitors warrant further study in transplant recipients.<\/jats:p>","DOI":"10.1093\/jscr\/rjag103","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:49:56Z","timestamp":1770382196000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive multifocal recurrent porocarcinoma of the face: a case report and review of the literature"],"prefix":"10.1093","volume":"2026","author":[{"given":"Mohsen","family":"Javam","sequence":"first","affiliation":[{"name":"Department of Surgery , University of Saskatoon, HSB, 107 Wiggins Rd B419, Saskatoon, SK, S7N 0W8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , University of Saskatchewan, 103 Hospital Drive Saskatoon, SK, S7N 0W8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Surgery , University of Saskatchewan, Suite B419, Health Sciences Building107 Wiggins Road, Saskatoon, S7N 5E5 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Shankaran","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery , University of Saskatoon, Medical Arts Building#102-750 Spadina Cres. E, Saskatoon, S7K 3H3 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Surgery , University of Saskatoon, HSB, 107 Wiggins Rd B419, Saskatoon, SK, S7N 0W8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"2026030703460332200_ref1","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3390\/diagnostics1308143","article-title":"Eccrine porocarcinoma: a review of the literature","volume":"13","author":"Tsiogka","year":"2023","journal-title":"Diagnostics"},{"key":"2026030703460332200_ref2","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.3390\/ijms25115760","article-title":"Porocarcinoma: clinical and histological features, immunohistochemistry and outcomes: a systematic 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