{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:35:22Z","timestamp":1773376522690,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Long-term left ventricular assist devices (LVAD) are an effective bridge-to-transplant strategy in end-stage heart failure. Prolonged device exposure may induce humoral activation, leading to anti-human leukocyte antigen (HLA) and non-HLA alloimmunization, complicating transplant access. We report a 43-year-old woman supported by a continuous-flow HeartWare ventricular assist device (HVAD) for 10\u00a0years, with severe anti-HLA hyperimmunization. She successfully underwent heart transplantation with stable hemodynamics, satisfactory early graft function, and no acute rejection. The postoperative course required multidisciplinary care, including hemodynamic, renal, respiratory, and infectious management, and evolved favorably. This case illustrates the feasibility of heart transplantation after prolonged LVAD support, even in highly sensitized patients, and highlights the importance of individualized immunological assessment and coordinated perioperative management.<\/jats:p>","DOI":"10.1093\/jscr\/rjag141","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:44:56Z","timestamp":1771418696000},"source":"Crossref","is-referenced-by-count":0,"title":["Successful heart transplant after 10\u00a0years of left ventricular assist device support in a highly sensitized patient"],"prefix":"10.1093","volume":"2026","author":[{"given":"Line","family":"El Oumeiri","sequence":"first","affiliation":[{"name":"Universit\u00e9 Libre de Bruxelles , Facult\u00e9 de M\u00e9decine, Route de Lennik, 808 1070 Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Stefanidis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universit\u00e9 Libre de Bruxeles, HUB-Erasme , Route de Lennik, 808 1070 Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanda","family":"Holovska","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Immunology, Universit\u00e9 Libre de Bruxeles, HUB-Erasme , Route de Lennik, 808 1070 Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Vanden Eynden","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universit\u00e9 Libre de Bruxeles, HUB-Erasme , Route de Lennik, 808 1070 Brussels ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachar","family":"El Oumeiri","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Universit\u00e9 Libre de Bruxeles, HUB-Erasme , Route de Lennik, 808 1070 Brussels 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implications","volume":"75","author":"Itescu","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2026031216234020400_ref4","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.healun.2016.05.001","article-title":"Immunologic effects of continuous-flow LVADs before and after transplant","volume":"35","author":"Ko","year":"2016","journal-title":"J Heart Lung Transplant"},{"key":"2026031216234020400_ref5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1056\/NEJMoa1602954","article-title":"Intrapericardial LVAD for advanced heart failure","volume":"376","author":"Rogers","year":"2017","journal-title":"N Engl J Med"},{"key":"2026031216234020400_ref6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.jchf.2018.05.012","article-title":"HVAD: the ENDURANCE supplemental trial","volume":"6","author":"Milano","year":"2018","journal-title":"JACC Heart Fail"},{"key":"2026031216234020400_ref7","author":"FDA Safety Communication","year":"2021"},{"key":"2026031216234020400_ref8","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/jocs.14066","article-title":"Outcomes after heart transplantation in sensitized patients bridged with LVADs","volume":"34","author":"Fraser","year":"2019","journal-title":"J Card Surg"},{"key":"2026031216234020400_ref9","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.healun.2009.04.031","article-title":"LVAD type affects degree of HLA-allosensitization","volume":"28","author":"Drakos","year":"2009","journal-title":"J Heart Lung Transplant"}],"container-title":["Journal of Surgical Case 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