{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T04:35:40Z","timestamp":1773376540286,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>3M syndrome is a rarely inherited autosomal recessive disorder caused by mutations in cullin-7 (CUL7), obscurin-like 1 (OBSL1), and coiled-coil domain containing protein 8 (CCDC8). It is associated with multiple dysmorphic features, including characteristic facial dysmorphism (a face that is triangular, full lips, frontal bossing, a nasal tip that is fleshy, long philtrum, protruding ears and macrocephaly), severe growth retardation prenatally and postnatally and normal intelligence. Although there are multiple skeletal manifestations of the syndrome, such as joint laxity, there is no mention of developmental dysplasia of the hip (DDH) to be associated with it anywhere in the literature. Therefore, we present the first case of bilateral DDH in a patient with 3M syndrome, which was managed similarly to other DDH cases with operative reduction, pelvic osteotomies, and femoral shortening, with a satisfactory outcome after 3\u00a0years of follow-up.<\/jats:p>","DOI":"10.1093\/jscr\/rjag154","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:42:33Z","timestamp":1771591353000},"source":"Crossref","is-referenced-by-count":0,"title":["First reported case of developmental dysplasia of the hips in a child with 3M syndrome: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Jameel H","family":"Fakeeha","sequence":"first","affiliation":[{"name":"Department of Orthopedics, King Saud Medical City , 7790, Imam Abdulaziz bin Mohammed bin Saud, Ulaishah Street, 12746 3617, Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha A","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, King Saud Medical City , 7790, Imam Abdulaziz bin Mohammed bin Saud, Ulaishah Street, 12746 3617, Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim F","family":"Alshugair","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, King Saud Medical City , 7790, Imam Abdulaziz bin Mohammed bin Saud, Ulaishah Street, 12746 3617, Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-8657","authenticated-orcid":false,"given":"Nouf A","family":"Altwaijri","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, King Saud Medical City , 7790, Imam Abdulaziz bin Mohammed bin Saud, Ulaishah Street, 12746 3617, Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"2026031216242322500_ref1","first-page":"39","article-title":"The 3-M syndrome: a heritable low birthweight dwarfism","volume":"11","author":"Miller","year":"1975","journal-title":"Birth Defects Orig Artic Ser"},{"key":"2026031216242322500_ref2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ajhg.2011.05.028","article-title":"Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth","volume":"89","author":"Hanson","year":"2011","journal-title":"Am J Human Genetics"},{"key":"2026031216242322500_ref3"},{"key":"2026031216242322500_ref4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.ajhg.2009.04.021","article-title":"The primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1","volume":"84","author":"Hanson","year":"2009","journal-title":"Am J Hum Genet"},{"key":"2026031216242322500_ref5","volume-title":"GeneReviews\u00ae","author":"Akilapa","year":"2002"},{"key":"2026031216242322500_ref6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2026031216242322500_ref7","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/mp.2016.113","article-title":"Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield","volume":"22","author":"Anazi","year":"2016","journal-title":"Mol Psychiatry"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag154\/67318612\/rjag154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag154\/67318612\/rjag154.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:24:27Z","timestamp":1773347067000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag154\/8516643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag154","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"rjag154"}}