{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:23:36Z","timestamp":1774016616141,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postoperative intra-abdominal abscesses are a common postsurgical complication and can lead to prolonged hospitalization and severe sepsis. The management of these abscesses is typically conservative, with intravenous antibiotics and percutaneous drainage. In those who fail conservative management, the next step is typically surgical intervention with washout. However, this may be contraindicated in a patient with multiple co-morbidities, who may not tolerate general anesthesia. Fibrinolysis via tissue plasminogen activator (tPA) and dornase infusion into the pleural cavity is well established for treatment of complicated empyemas. In comparison, infusion into the abdominal cavity has only been reported in one case series. In this case report, we describe our experience successfully treating an intraabdominal abscess with administration of tPA-dornase into the intra-abdominal cavity.<\/jats:p>","DOI":"10.1093\/jscr\/rjag177","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:27:36Z","timestamp":1774009656000},"source":"Crossref","is-referenced-by-count":0,"title":["Infusion of tPA-dornase for management of intraabdominal abscesses: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Winnie","family":"Long","sequence":"first","affiliation":[{"name":"Department of Surgery, The Brooklyn Hospital Center , 121 Dekalb Ave, Brooklyn, NY 11201 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Brooklyn Hospital Center , 121 Dekalb Ave, Brooklyn, NY 11201 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Einersen","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Brooklyn Hospital Center , 121 Dekalb Ave, Brooklyn, NY 11201 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"2026032008273364500_ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.91100","article-title":"Postoperative intra-abdominal abscess following general surgery: a systematic review of risk factors, prevention, and the role of laparotomy","volume-title":"Cureus","author":"","year":"2025"},{"key":"2026032008273364500_ref2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1056\/NEJMoa1012740","article-title":"Intrapleural use of tissue plasminogen activator and DNase in pleural infection","volume":"365","author":"Rahman","year":"2011","journal-title":"N Engl J Med"},{"key":"2026032008273364500_ref3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1055\/S-0032-1330060","article-title":"Use of fibrinolytics in abdominal and pleural collections","volume":"29","author":"Shenoy-Bhangle","year":"2012","journal-title":"Semin Intervent Radiol"},{"key":"2026032008273364500_ref4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/87551225241288133","article-title":"Combination dornase and alteplase for intra-abdominal drain, abscess, and hematoma clearance: a retrospective case series","volume":"41","author":"Schultz","year":"2024","journal-title":"J Pharm Technol"},{"key":"2026032008273364500_ref5","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4236\/OJRAD.2016.63027","article-title":"A randomized prospective assessment of safety and effectiveness of instillation of tissue plasminogen activator in the management of intra-abdominal abscesses","volume":"6","author":"Kotecha","year":"2016","journal-title":"Open J Radiol"},{"key":"2026032008273364500_ref6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/J.JAMCOLLSURG.2015.03.043","article-title":"Saline vs tissue plasminogen activator irrigations after drain placement for appendicitis-associated abscess: a prospective randomized trial","volume":"221","author":"St Peter","year":"2015","journal-title":"J Am Coll Surg"},{"key":"2026032008273364500_ref7","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/0846537120914263","article-title":"Use of tissue plasminogen activator in abdominal abscesses in children\u2014a single-center randomized control trial","volume":"72","author":"Gibson","year":"2021","journal-title":"Can Assoc Radiol J"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag177\/67433228\/rjag177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag177\/67433228\/rjag177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:27:37Z","timestamp":1774009657000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag177\/8530445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag177","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"rjag177"}}