{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T17:51:55Z","timestamp":1774201915087,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fecal calprotectin (FCAL) is commonly used to exclude inflammatory bowel disease in patients with symptoms of the irritable bowel syndrome spectrum. This retrospective case\u2013control study evaluated FCAL levels in 81 postoperative patients to assess the impact of different gastrointestinal surgeries. Thirty-one patients had undergone esophago-gastric surgery (fundoplication or Roux-en-Y gastric bypass), and 50 had undergone colon surgery with hemicolectomy. Elevated FCAL levels (&amp;gt;50\u00a0\u03bcg\/g) were observed in 56.7% of patients after esophago-gastric surgery compared with 24% of patients after hemicolectomy. Median FCAL levels were 96\u00a0\u03bcg\/g and 99\u00a0\u03bcg\/g, respectively. Statistically significant differences in FCAL levels were found between patients who underwent left-sided hemicolectomy and those who underwent Roux-en-Y bypass (P\u2009&amp;lt;\u2009.001), as well as right-sided hemicolectomy (P\u2009=\u2009.042). Overall, elevated FCAL levels were more than twice as common following esophago-gastric surgery, suggesting surgery-specific patterns of postoperative intestinal inflammation.<\/jats:p>","DOI":"10.1093\/jscr\/rjag188","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T17:10:13Z","timestamp":1774199413000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevated fecal calprotectin values appear more common following esophagogastric than colon surgery"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-5230","authenticated-orcid":false,"given":"Wolfgang J","family":"Schnedl","sequence":"first","affiliation":[{"name":"Division of Immunology, Otto Loewi Research Center, Medical University of Graz , Neue Stiftingtalstra\u00dfe 6, Graz, A-8010 ,","place":["Austria"]},{"name":"General Internal Medicine Practice , Dr. Theodor K\u00f6rnerstrasse 19b, Bruck, A-8600 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Michaelis","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, Hospital Hochsteiermark , Vordernberger Stra\u00dfe 42, Leoben, A-8700 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Schrittwieser","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Hospital Hochsteiermark , Vordernberger Stra\u00dfe 42, Leoben, A-8700 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Enko","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, Hospital Hochsteiermark , Vordernberger Stra\u00dfe 42, Leoben, A-8700 ,","place":["Austria"]},{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Auenbruggerplatz 15, Graz, A-8036 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra J","family":"Holasek","sequence":"additional","affiliation":[{"name":"Division of Immunology, Otto Loewi Research Center, Medical University of Graz , Neue Stiftingtalstra\u00dfe 6, Graz, A-8010 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,22]]},"reference":[{"key":"2026032213101535700_ref1","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1136\/gutjnl-2021-324855","article-title":"Calprotectin: from biomarker to biological function","volume":"70","author":"Jukic","year":"2021","journal-title":"Gut"},{"key":"2026032213101535700_ref2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/ueg2.12259","article-title":"Functional bowel disorders with diarrhoea: clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility","volume":"10","author":"Savarino","year":"2022","journal-title":"United European Gastroenterol J"},{"key":"2026032213101535700_ref3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1159\/000514196","article-title":"Optimal range of fecal calprotectin for predicting mucosal healing in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"37","author":"Xiang","year":"2021","journal-title":"Visc Med"},{"key":"2026032213101535700_ref4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.15698\/cst2023.10.290","article-title":"Gut microbiota turn up the heat after bariatric surgery","volume":"7","author":"Hankir","year":"2023","journal-title":"Cell Stress"},{"key":"2026032213101535700_ref5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1308\/rcsann.2023.0046","article-title":"Long-term efficacy of total versus posterior partial fundoplication in patients with gastro-oesophageal reflux disease: a systematic review and meta-analysis","volume":"106","author":"Peristeri","year":"2024","journal-title":"Ann R Coll Surg Engl"},{"key":"2026032213101535700_ref6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00384-024-04593-z","article-title":"Development of an image-based random Forest classifier for prediction of surgery duration of laparoscopic sigmoid resections","volume":"39","author":"Lippenberger","year":"2024","journal-title":"Int J Color Dis"},{"key":"2026032213101535700_ref7","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1007\/s11695-016-2222-0","article-title":"Fecal calprotectin, elastase, and alpha-1-antitrypsin levels after Roux-en-Y gastric bypass; calprotectin is significantly elevated in the majority of patients","volume":"26","author":"Boerlage","year":"2016","journal-title":"Obes Surg"},{"key":"2026032213101535700_ref8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12979-023-00352-w","article-title":"Aging and chronic inflammation: highlights from a multidisciplinary workshop","volume":"20","author":"Saavedra","year":"2023","journal-title":"Immun Ageing"},{"key":"2026032213101535700_ref9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-pathmechdis-051222-015009","article-title":"Neutrophils in physiology and pathology","volume":"19","author":"Aroca-Crevill\u00e9n","year":"2024","journal-title":"Annu Rev Pathol"},{"key":"2026032213101535700_ref10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/MCG.0000000000001359","article-title":"Clinical performance of a novel LIAISON fecal calprotectin assay for differentiation of inflammatory bowel disease from irritable bowel syndrome","volume":"55","author":"Campbell","year":"2021","journal-title":"J Clin Gastroenterol"},{"key":"2026032213101535700_ref11","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1515\/cclm-2016-0522","article-title":"Faecal calprotectin in inflammatory bowel diseases: update and perspectives","volume":"55","author":"Manceau","year":"2017","journal-title":"Clin Chem Lab Med"},{"key":"2026032213101535700_ref12","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.crohns.2014.06.002","article-title":"The intra-individual variability of faecal calprotectin: a prospective study in patients with active ulcerative colitis","volume":"9","author":"Lasson","year":"2015","journal-title":"J Crohns Colitis"},{"key":"2026032213101535700_ref13","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3390\/nu15051179","article-title":"Fecal calprotectin elevations associated with food intolerance\/malabsorption are significantly reduced with targeted diets","volume":"15","author":"Schnedl","year":"2023","journal-title":"Nutrients"},{"key":"2026032213101535700_ref14","doi-asserted-by":"publisher","first-page":"13513","DOI":"10.1038\/s41598-024-63893-0","article-title":"Elevated fecal calprotectin is associated with gut microbial dysbiosis, altered serum markers and clinical outcomes in older individuals","volume":"14","author":"Heinzel","year":"2024","journal-title":"Sci Rep"},{"key":"2026032213101535700_ref15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/biom15040557","article-title":"Fecal calprotectin as a prognostic biomarker for mortality and renal outcomes in chronic kidney disease","volume":"15","author":"Lee","year":"2025","journal-title":"Biomolecules"},{"key":"2026032213101535700_ref16","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/ueg2.12633","article-title":"Assessment of intestinal inflammation via fecal calprotectin for early prediction of adverse outcomes in advanced chronic liver disease","volume":"13","author":"Koller","year":"2025","journal-title":"United European Gastroenterol J"},{"key":"2026032213101535700_ref17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern Emerg Med"},{"key":"2026032213101535700_ref18","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10151-023-02857-4","article-title":"Long-term oncological outcomes of robotic versus laparoscopic approaches for right colon cancer: a systematic review and meta-analysis","volume":"27","author":"Kim","year":"2023","journal-title":"Tech Coloproctol"},{"key":"2026032213101535700_ref19","doi-asserted-by":"publisher","first-page":"e071027","DOI":"10.1136\/bmj-2022-071027","article-title":"Long term outcomes of metabolic\/bariatric surgery in adults","volume":"383","author":"Courcoulas","year":"2023","journal-title":"BMJ"},{"key":"2026032213101535700_ref20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/pace.14896","article-title":"Fecal calprotectin: a novel predictor of ulcerated esophageal injury after atrial fibrillation catheter ablation","volume":"47","author":"Wang","year":"2024","journal-title":"Pacing Clin Electrophysiol"},{"key":"2026032213101535700_ref21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1159\/000514576","article-title":"Faecal inflammatory biomarkers and gastrointestinal symptoms after bariatric surgery: a longitudinal study","volume":"6","author":"Westerink","year":"2021","journal-title":"Inflamm Intest Dis"},{"key":"2026032213101535700_ref22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/jpn3.12053","article-title":"Intestinal dysbiosis and inflammation in children with repaired esophageal atresia","volume":"78","author":"Traini","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2026032213101535700_ref23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12885-022-09440-4","article-title":"Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: a retrospective study","volume":"22","author":"Blad","year":"2022","journal-title":"BMC Cancer"},{"key":"2026032213101535700_ref24","doi-asserted-by":"publisher","first-page":"e0246091","DOI":"10.1371\/journal.pone.0246091","article-title":"Guidance on the interpretation of faecal calprotectin levels in children","volume":"16","author":"Orfei","year":"2021","journal-title":"PloS One"},{"key":"2026032213101535700_ref25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12916-022-02301-8","article-title":"Immune responses in the irritable bowel syndromes: time to consider the small intestine","volume":"20","author":"Burns","year":"2022","journal-title":"BMC Med"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag188\/67471467\/rjag188.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag188\/67471467\/rjag188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T17:10:26Z","timestamp":1774199426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag188\/8537037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag188","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"rjag188"}}