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Endoscopic evaluation revealed mucosal nodularity in the second portion of the duodenum. Biopsies confirmed metastatic breast carcinoma immunohistochemically positive for GATA3 and mammaglobin, and negative for CK20, indicating breast origin. This case highlights the importance of considering gastrointestinal metastasis in patients with prior breast cancer presenting with gastrointestinal symptoms. Early endoscopic assessment and immunohistochemical confirmation were key to diagnosis. Clinicians should maintain a high index of suspicion for atypical metastatic patterns in patients with advanced breast carcinoma.<\/jats:p>","DOI":"10.1093\/jscr\/rjag210","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T09:38:52Z","timestamp":1774777132000},"source":"Crossref","is-referenced-by-count":0,"title":["Duodenal metastasis from breast carcinoma presenting with refractory nausea and vomiting: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Su Su","family":"(Shannon) Naing","sequence":"first","affiliation":[{"name":"Department of General Surgery, The Hervey Bay Hospital , Hervey Bay, Cnr Nissen Street, &, 141\/169 Urraween Rd, Pialba QLD 4655 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"2026032905384998900_ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.14218\/OnA.2024.00001","article-title":"Breast cancer metastasizing to the lower gastrointestinal tract (the small bowel and colon): a case presentation and comprehensive review of the literature","volume":"2","author":"Da Cunha","year":"2024","journal-title":"Oncol Adv"},{"key":"2026032905384998900_ref2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/PAP.0000000000000256","article-title":"An algorithmic immunohistochemical approach to define tumor type and assign site of origin","volume":"27","author":"Bellizzi","year":"2020","journal-title":"Adv Anat Pathol"},{"key":"2026032905384998900_ref3","first-page":"331","article-title":"Utility of mammaglobin and gross cystic disease fluid protein-15 (GCDFP-15) in confirming a breast origin for recurrent tumors","volume":"16","author":"Tanioka","year":"2009","journal-title":"Breast Cancer"},{"key":"2026032905384998900_ref4","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/jnci\/djx273","article-title":"Receptor conversion in distant breast cancer metastases: a systematic review and meta-analysis","volume":"110","author":"Schrijver","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"2026032905384998900_ref5","doi-asserted-by":"publisher","first-page":"rjac080","DOI":"10.1093\/jscr\/rjac080","article-title":"Gastric metastasis from breast cancer presenting as dysphagia","volume":"2022","author":"Fousekis","year":"2022","journal-title":"J Surg Case Rep"},{"key":"2026032905384998900_ref6","doi-asserted-by":"publisher","first-page":"e9623","DOI":"10.1097\/MD.0000000000009623","volume":"97","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2026032905384998900_ref7","doi-asserted-by":"publisher","first-page":"1475018","DOI":"10.3389\/fimmu.2024.1475018","article-title":"Small intestinal metastasis from primary breast cancer: a case report and review of literature","volume":"15","author":"Shen","year":"2024","journal-title":"Front Immunol"},{"key":"2026032905384998900_ref8","doi-asserted-by":"publisher","first-page":"746","DOI":"10.5603\/rpor.98730","article-title":"Hormone receptor conversion in metastatic breast cancer","volume":"28","author":"Proch\u00e1zkov\u00e1","year":"2024","journal-title":"Rep Pract Oncol Radiother"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag210\/67636902\/rjag210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/3\/rjag210\/67636902\/rjag210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T09:38:53Z","timestamp":1774777133000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag210\/8555573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag210","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"rjag210"}}