{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:46:47Z","timestamp":1776016007606,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute appendicitis is a common surgical emergency, and antibiotic therapy is a safe and effective alternative to surgery for computed tomography (CT)-confirmed uncomplicated cases. Rarely, an underlying appendiceal tumor may present as acute or recurrent appendicitis. We report the case of a man in his early 60s with CT-confirmed uncomplicated appendicitis who initially recovered with antibiotics but re-presented 6 weeks later with recurrent symptoms. Laparoscopic appendectomy revealed a goblet cell adenocarcinoma (GCA, pT4a) of the appendix with lymphatic and perineural invasion. Staging imaging showed no synchronous colorectal lesions or metastases. Completion right hemicolectomy demonstrated no residual tumor or lymph node involvement (0\/26; final stage pT4N0M0). Adjuvant chemotherapy was not administered, and at 1-year follow-up the patient remains disease-free. This case highlights that although appendiceal malignancy is rare in uncomplicated appendicitis, recurrence should prompt definitive surgical management and careful pathological evaluation, particularly in adults.<\/jats:p>","DOI":"10.1093\/jscr\/rjag248","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:48:51Z","timestamp":1773838131000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent uncomplicated appendicitis in an adult reveals an underlying goblet cell adenocarcinoma: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Pia","family":"Nordstr\u00f6m","sequence":"first","affiliation":[{"name":"Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital , El\u00e4m\u00e4naukio 2, 33520 Tampere ,","place":["Finland"]},{"name":"Faculty of Medicine and Health Technology, Tampere University , Arvo Ylp\u00f6n katu 34, 33520 Tampere ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Rinta-Kiikka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University , Arvo Ylp\u00f6n katu 34, 33520 Tampere ,","place":["Finland"]},{"name":"Department of Radiology, Tampere University Hospital , El\u00e4m\u00e4naukio 2, 33520 Tampere ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2026041213080219800_ref1","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1001\/jama.2015.6154","article-title":"Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical 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Surg"},{"key":"2026041213080219800_ref5","volume-title":"Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","edition":"5th"},{"key":"2026041213080219800_ref6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.5858\/arpa.2013-0047-OA","article-title":"Goblet cell carcinoid tumor, mixed goblet cell carcinoid\u2013adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis","volume":"139","author":"Taggart","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"2026041213080219800_ref7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.4240\/wjgs.v8.i10.660","article-title":"Goblet cell adenocarcinoma of the appendix","volume":"8","author":"Shenoy","year":"2016","journal-title":"World J Gastrointest Surg"},{"key":"2026041213080219800_ref8","doi-asserted-by":"publisher","first-page":"915028","DOI":"10.3389\/fonc.2022.915028","article-title":"Goblet cell adenocarcinoma of the appendix: a systematic review and incidence and survival of 1,225 cases from an English cancer registry","volume":"12","author":"Palmer","year":"2022","journal-title":"Front Oncol"},{"key":"2026041213080219800_ref9","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1001\/jama.2018.13201","article-title":"Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial","volume":"320","author":"Salminen","year":"2018","journal-title":"JAMA"},{"key":"2026041213080219800_ref10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1001\/jama.2020.23525","article-title":"Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin and metronidazole for uncomplicated acute appendicitis (APPAC II trial)","volume":"325","author":"Sippola","year":"2021","journal-title":"JAMA."},{"key":"2026041213080219800_ref11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"A consensus for classification and pathologic reporting of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"}],"container-title":["Journal of Surgical Case 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