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The ulcer managed by excision of the ulcer and complete enucleation of the attached lesion from the bony defect with curettage and reconstructed by bone regeneration procedure and final diagnosis was ameloblastoma. Ameloblastoma management starts from simple enucleation and curettage for small lesion to massive resection with safety margin which needs advance surgery for reconstruction of the mouth to restore normal function. What is unique in this case is regeneration of the defect by particulate bone graft and membrane as none of the reported literature utilized the same technique. Healing went uneventful. Patient resumed normal life activity within 2\u20133\u00a0weeks post-operatively ensuring a good quality of life with no sign of recurrence after 1\u00a0year.<\/jats:p>","DOI":"10.1093\/jscr\/rjag290","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:47:51Z","timestamp":1775130471000},"source":"Crossref","is-referenced-by-count":0,"title":["Unusual clinical presentation of ameloblastoma: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Abdulelah","family":"AlSubaie","sequence":"first","affiliation":[{"name":"Dental Specialist Center , AlAhsa, Al Mubarraz 36441 ,","place":["Saudi Arabia"]},{"name":"Dental Department, King Faisal General Hospital , AlAhsa, Al Hofuf 36361 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M","family":"AlAli","sequence":"additional","affiliation":[{"name":"Prince Saud Bin Jalawi Hospital , AlAhsa, Al Mubarraz 36424 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Aldabbus","sequence":"additional","affiliation":[{"name":"Dental Department, King Faisal General Hospital , AlAhsa, Al Hofuf 36361 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhadi","family":"AlAli","sequence":"additional","affiliation":[{"name":"Dental Department, King Faisal General Hospital , AlAhsa, Al Hofuf 36361 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-6712","authenticated-orcid":false,"given":"Nasser","family":"Almadan","sequence":"additional","affiliation":[{"name":"Dental Specialist Center , Hafar AlBatin 3992 ,","place":["Saudi Arabia"]},{"name":"Dental Department, Prince Sultan Miltary Medical City , Riyadh 12233 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"2026042214120502600_ref1","volume-title":"International Agency for Research on Cancer","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"2026042214120502600_ref2","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/diagnostics14090910","article-title":"Frequency and demographic analysis of odontogenic tumors in three tertiary institutions: an 11-year retrospective study","volume":"14","author":"Almazyad","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"2026042214120502600_ref3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/0022034514560373","article-title":"Novel targets for the treatment of ameloblastoma","volume":"94","author":"Heikinheimo","year":"2015","journal-title":"J Dent Res"},{"key":"2026042214120502600_ref4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3390\/bioengineering11060571","article-title":"Classification of ameloblastoma, periapical cyst, and chronic suppurative osteomyelitis with semi-supervised learning: the WaveletFusion-ViT model approach","volume":"11","author":"Liang","year":"2024","journal-title":"Bioengineering (Basel, Switzerland)"},{"key":"2026042214120502600_ref5","doi-asserted-by":"publisher","first-page":"107457","DOI":"10.1016\/j.ijscr.2022.107457","article-title":"Asymptomatic ameloblastoma of the maxilla with infratemporal fossa involvement: a case report","volume":"98","author":"Chebil","year":"2022","journal-title":"Int J Surg Case Rep"},{"key":"2026042214120502600_ref6","first-page":"54","article-title":"An unusual clinical and histopathologic presentation of a maxillofacial ameloblastoma: a literature review and case report","volume":"72","author":"Parashar","year":"2024","journal-title":"Gen Dent"},{"key":"2026042214120502600_ref7","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1111\/odi.13014","article-title":"Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis","volume":"25","author":"Hendra","year":"2019","journal-title":"Oral Dis"},{"key":"2026042214120502600_ref8","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.joms.2022.03.003","article-title":"Surgical treatment of ameloblastoma: how does it impact the oral health-related quality of life? A systematic review","volume":"80","author":"Campos","year":"2022","journal-title":"J Oral Maxillofacial Surg"},{"key":"2026042214120502600_ref9","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1111\/odi.14962","article-title":"Targeted therapies in ameloblastomas and amelobastic carcinoma-a systematic review","volume":"30","author":"Bologna-Molina","year":"2024","journal-title":"Oral Dis"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag290\/68137977\/rjag290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag290\/68137977\/rjag290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:12:12Z","timestamp":1776881532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag290\/8661032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag290","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4,1]]},"article-number":"rjag290"}}