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This case report describes the use of artificial intelligence (AI)-assisted CBCT segmentation combined with three-dimensional (3D) printing for surgical planning and orthodontic traction of a palatal impacted canine in a unilateral CLP patient. AI-based segmentation enabled precise localization of the impacted tooth and adjacent structures, and a patient-specific 3D printed model was fabricated to guide surgical access and traction direction. A minimally invasive mucoperiosteal flap was performed, followed by immediate light orthodontic traction. The digital workflow facilitated accurate exposure and controlled biomechanical movement without complications. The integration of AI and 3D printing may enhance precision and efficiency in managing complex impacted canine cases associated with CLP.<\/jats:p>","DOI":"10.1093\/jscr\/rjag323","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:43:18Z","timestamp":1776253398000},"source":"Crossref","is-referenced-by-count":0,"title":["AI and 3D printing-assisted surgical exposure of impacted canines and tooth extraction in complex cleft lip and palate orthodontic treatment"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5139-452X","authenticated-orcid":false,"given":"Viet","family":"Hoang","sequence":"first","affiliation":[{"name":"Digital Industrial Design and Manufacturing Research Unit, Faculty of Engineering at Sriracha, Kasetsart University , Sriracha, Chonburi, 20110,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Huu","family":"Khoi","sequence":"additional","affiliation":[{"name":"Singdent Dental Group , 01 Nguyen Thi Thap Street, Tan Hung Ward, Ho Chi Minh City , 70000,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattapon","family":"Chantarapanich","sequence":"additional","affiliation":[{"name":"Digital Industrial Design and Manufacturing Research Unit, Faculty of Engineering at Sriracha, Kasetsart University , Sriracha, Chonburi, 20110,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Hong","family":"Phuoc","sequence":"additional","affiliation":[{"name":"Singdent Dental Group , 01 Nguyen Thi Thap Street, Tan Hung Ward, Ho Chi Minh City , 70000,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-4393","authenticated-orcid":false,"given":"Anand","family":"Marya","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Puthisastra , No. 55 Street 180-184, Phnom Penh 12211 ,","place":["Cambodia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026042813251285500_ref1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s12663-023-02062-8","article-title":"A novel three-dimensional surgical guide for exposure of Palatally impacted teeth: a case report","volume":"23","author":"Sankaranarayanan","year":"2024","journal-title":"J Maxillofac Oral Surg"},{"key":"2026042813251285500_ref2","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1186\/s12903-025-07117-5","article-title":"Deep learning-based 3D automatic segmentation of impacted canines in CBCT scans","volume":"25","author":"\u00dcnal","year":"2025","journal-title":"BMC Oral 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