{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:54:23Z","timestamp":1777542863402,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary arteriovenous malformations (PAVMs) are abnormal communications between an artery and a vein without an intervening capillary component. Most PAVMs are congenital, caused by hereditary hemorrhagic telangiectasia, but around 20% are acquired. The most common presenting symptom is dyspnoea on exertion, but patients can be completely asymptomatic. Furthermore, Gestational trophoblastic neoplasia (GTN) is a group of rare tumors that arise from abnormal growth of trophoblastic tissue which includes invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor can progress, invade, metastasize, and lead to death if left untreated. In the majority of GTNs, the disease is limited to the uterus where the abnormal trophoblast proliferation and localized hCG production may lead to focal vascular changes, including the formation of AVMs. Most patients with GTN present with abnormal vaginal bleeding but they can also present with bleeding from metastatic sites. Symptoms of pulmonary metastasis from GTN often include cough, hemoptysis, and chest pain. However, PAVMs are not typically listed as a direct consequence of this metastatic spread. Here, we report a rare case of metastatic GTN initially presented with pulmonary vascular malformation.<\/jats:p>","DOI":"10.1093\/jscr\/rjag333","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:13:29Z","timestamp":1776510809000},"source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary arteriovenous malformations as an unusual initial manifestation of gestational trophoblastic neoplasia: a case report from Saudi Arabia"],"prefix":"10.1093","volume":"2026","author":[{"given":"Modhi Mohammed","family":"AlJumah","sequence":"first","affiliation":[{"name":"Obstetric and Gynecology Resident, King Khalid University Hospital, King Saud University Medical City , Riyadh 12372 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani Abdulmohsen","family":"AlHalal","sequence":"additional","affiliation":[{"name":"Gynecologic Oncologist Consultant, King Khalid University Hospital, King Saud University Medical City , Riyadh 12372 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Khalid","family":"alzaydan","sequence":"additional","affiliation":[{"name":"Obstetric and Gynecology Consultant, King Khalid University Hospital, King Saud University Medical City , Riyadh 12372 ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026042813250897800_ref1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/JTO.0b013e318031d086","article-title":"Development of pulmonary arteriovenous communications within pulmonary metastases after chemotherapy","volume":"2","author":"Bruzzi","year":"2007","journal-title":"J Thorac Oncol"},{"key":"2026042813250897800_ref2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1515\/med-2015-0093","article-title":"Pulmonary arterovenous malformation causing hemothorax in a pregnant woman without Osler-weber-Rendu syndrome","volume":"10","author":"Di Crescenzo","year":"2015","journal-title":"Open Med (Wars)"},{"key":"2026042813250897800_ref3","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.2214\/ajr.181.6.1811544","article-title":"Pulmonary arteriovenous fistulas developed after chemotherapy of metastatic choriocarcinoma","volume":"181","author":"Choi","year":"2003","journal-title":"AJR Am J Roentgenol"},{"key":"2026042813250897800_ref4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1378\/chest.103.1.269","article-title":"A persistent pulmonary lesion following chemotherapy for metastatic choriocarcinoma","volume":"103","author":"Casson","year":"1993","journal-title":"Chest"},{"key":"2026042813250897800_ref5","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/S0025-6196(25)16796-7","article-title":"Pulmonary arteriovenous fistulas","volume":"49","author":"Arms","year":"1974","journal-title":"Mayo Clin Proc"},{"key":"2026042813250897800_ref6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1164\/arrd.1969.100.2.177","article-title":"Pulmonary arteriovenous fistula. Diagnosis and prognosis in noncomplainant patients","volume":"100","author":"Sluiter-Eringa","year":"1969","journal-title":"Am Rev Respir Dis"},{"key":"2026042813250897800_ref7","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/0002-9610(55)90580-8","article-title":"Pulmonary arteriovenous fistula","volume":"89","author":"Stringer","year":"1955","journal-title":"Am J Surg"},{"key":"2026042813250897800_ref8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1378\/chest.43.5.449","article-title":"Pulmonary arteriovenous fistula and hereditary hemorrhagic telangiectasia: a review and report of 35 cases of fistula","volume":"43","author":"Hodgson","year":"1963","journal-title":"Dis Chest"},{"key":"2026042813250897800_ref9","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1136\/thx.50.7.707","article-title":"Pulmonary arteriovenous malformations","volume":"50","author":"Robertson","year":"1995","journal-title":"Thorax"},{"key":"2026042813250897800_ref10","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.1016\/j.ijgo.2015.06.008","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"131","author":"Ngan","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"2026042813250897800_ref11","doi-asserted-by":"publisher","first-page":"vi39","DOI":"10.1093\/annonc\/mdt345","article-title":"Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","author":"Seckl","year":"2013","journal-title":"Ann Oncol"},{"key":"2026042813250897800_ref12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1752-1947-8-117","article-title":"Haemoptysis from a pulmonary arteriovenous malformation in a post molar pregnancy gestational trophoblast tumour patient managed by radiological embolisation: a case report","volume":"8","author":"McDonald-Burrows","year":"2014","journal-title":"J Med Case Reports"},{"key":"2026042813250897800_ref13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.placenta.2003.10.004","article-title":"Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation","volume":"25","author":"Charnock-Jones","year":"2004","journal-title":"Placenta"},{"key":"2026042813250897800_ref14","doi-asserted-by":"publisher","first-page":"100635","DOI":"10.1016\/j.gore.2020.100635","article-title":"Pulmonary arterial venous malformations as primary manifestation of gestational trophoblastic neoplasia","volume":"34","author":"Cain","year":"2020","journal-title":"Gynecol Oncol Rep"},{"key":"2026042813250897800_ref15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1200\/JCO.2012.43.1817","article-title":"EMA\/CO for high-risk gestational trophoblastic neoplasia: good outcomes with induction low-dose etoposide-cisplatin and genetic analysis","volume":"31","author":"Alifrangis","journal-title":"J Clin Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag333\/68180524\/rjag333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag333\/68180524\/rjag333.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:14Z","timestamp":1777397114000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag333\/8664209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag333","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4,1]]},"article-number":"rjag333"}}