{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:55:07Z","timestamp":1777877707269,"version":"3.51.4"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Giant testicular tumours are rare in contemporary practice and are typically associated with delayed diagnosis and advanced disease. We report a 32-year-old male presenting with a 1-month history of progressively enlarging, painful right-sided scrotal swelling, initially mischaracterized on ultrasound imaging performed abroad. Examination revealed marked scrotal enlargement with overlying erythema and a buried penis. Computed tomography demonstrated a large right testicular mass with retroperitoneal lymphadenopathy, without distant metastases. Serum tumour markers showed elevated \u03b2-human chorionic gonadotropin and lactate dehydrogenase, with normal alpha-fetoprotein. The patient underwent urgent radical inguinal orchidectomy. Histopathology confirmed a pure seminoma measuring 15.8\u00a0cm with lymphovascular invasion and spermatic cord involvement (pT3). Post-operatively, tumour markers declined significantly, and the patient was commenced on bleomycin, etoposide, and cisplatin chemotherapy. This case emphasizes that painful scrotal swelling does not exclude malignancy and highlights the importance of early recognition and multidisciplinary management.<\/jats:p>","DOI":"10.1093\/jscr\/rjag342","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:41:38Z","timestamp":1777030898000},"source":"Crossref","is-referenced-by-count":0,"title":["Giant testicular seminoma with atypical painful presentation and delayed diagnosis: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Fuad Haj","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Urology, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust , Haslingden Road, Blackburn BB2 3HH, England ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-9824","authenticated-orcid":false,"given":"Eyad","family":"Jamileh","sequence":"additional","affiliation":[{"name":"Department of Urology, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust , Haslingden Road, Blackburn BB2 3HH, England ,","place":["United Kingdom"]},{"name":"School of Medicine, Queens University Belfast , University Road, Belfast BT7 1NN, Northern Ireland ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faeza","family":"Limbada","sequence":"additional","affiliation":[{"name":"Department of Urology, Royal Blackburn Hospital, East Lancashire Hospitals NHS Trust , Haslingden Road, Blackburn BB2 3HH, England ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"2026043018591948100_ref1","first-page":"261","article-title":"Testicular cancer: diagnosis and treatment","volume":"97","author":"Baird","year":"2018","journal-title":"Am Fam Physician"},{"key":"2026043018591948100_ref2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0140-6736(25)00455-6","article-title":"Testicular cancer","volume":"406","author":"Chavarriaga","year":"2025","journal-title":"Lancet"},{"key":"2026043018591948100_ref3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3322\/caac.21819","article-title":"Testicular cancer in 2023: current status and recent progress","volume":"74","author":"McHugh","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2026043018591948100_ref4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s1040-8428(00)00074-3","article-title":"Intensive and timely chemotherapy, the key of success in testicular cancer","volume":"37","author":"Fl\u00e9chon","year":"2001","journal-title":"Crit Rev Oncol Hematol"},{"key":"2026043018591948100_ref5","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1016\/j.urology.2012.06.031","article-title":"Giant testicular seminoma","volume":"80","author":"Ellimoottil","year":"2012","journal-title":"Urology"},{"key":"2026043018591948100_ref6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4103\/2278-0513.142704","article-title":"Giant mixed germ cell tumor of the testis: a rare presentation","volume":"3","author":"Khosla","year":"2014","journal-title":"Clin Cancer Investig J"},{"key":"2026043018591948100_ref7","doi-asserted-by":"publisher","first-page":"101234","DOI":"10.1016\/j.eucr.2020.101234","article-title":"Giant testicular tumour with major choriocarcinoma component","volume":"32","author":"Jackson","year":"2020","journal-title":"Urol Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag342\/68198276\/rjag342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/4\/rjag342\/68198276\/rjag342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:59:27Z","timestamp":1777589967000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag342\/8666079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag342","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,4,1]]},"article-number":"rjag342"}}