{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:18:31Z","timestamp":1778923111507,"version":"3.51.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Musculocontractural Ehlers\u2013Danlos syndrome (mcEDS) is a rare connective tissue disorder characterized by abnormal collagen structure, tissue fragility, and predisposition to disproportionate hematoma formation following trivial trauma. Large expanding hematomas may lead to tissue necrosis, thereby requiring urgent decision-making and rapid intervention. We report a case of a 10-year-old boy with mcEDS and Dandy\u2013Walker syndrome who presented after a minor fall with rapidly progressive swelling of the right lower limb and a history of recurrent post-traumatic hematomas. Clinical deterioration prompted urgent exploration, revealing a large, organized hematoma, and friable devitalized tissues. Extensive debridement, staged wound care, and split-thickness skin grafting were performed. Microbiology was negative, confirming a traumatic hematoma with secondary soft-tissue compromise related to the connective tissue disorder. Minor trauma in patients with mcEDS may cause severe limb-threatening hematomas with tissue necrosis. Early recognition and prompt surgical intervention are essential to prevent ischemic injury and improve reconstructive outcomes.<\/jats:p>","DOI":"10.1093\/jscr\/rjag367","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:15:39Z","timestamp":1777637739000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent massive hematoma after trivial trauma in Ehlers\u2013Danlos syndrome: a case report highlighting diagnostic urgency and surgical challenges"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-9101","authenticated-orcid":false,"given":"Mohamed B","family":"Ahmed","sequence":"first","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital, Hamad Medical Corporation , Doha ,","place":["Qatar"]},{"name":"College of Medicine, QU Health, Qatar University , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hillal","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Plastic and Craniofacial Surgery, Sidra Medicine , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawar","family":"Nissar","sequence":"additional","affiliation":[{"name":"Division of Plastic and Craniofacial Surgery, Sidra Medicine , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima S","family":"Al-Mohannadi","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Hamad General Hospital, Hamad Medical Corporation , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haithem E","family":"Babiker","sequence":"additional","affiliation":[{"name":"Division of Plastic and Craniofacial Surgery, Sidra Medicine , Doha ,","place":["Qatar"]},{"name":"Weill Cornell Medicine , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"2026051605040912700_ref1","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/ajmg.a.33498","article-title":"A new Ehlers-Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations","volume":"152A","author":"Kosho","year":"2010","journal-title":"Am J Med Genet A"},{"key":"2026051605040912700_ref2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-020-0194-9","article-title":"The Ehlers-Danlos syndromes","volume":"6","author":"Malfait","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2026051605040912700_ref3","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1136\/jmedgenet-2020-107623","article-title":"Clinical and molecular features of 66 patients with 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musculocontractural Ehlers-Danlos syndrome (mcEDS)","volume":"138","author":"Laggner","year":"2026","journal-title":"Wien Klin Wochenschr"},{"key":"2026051605040912700_ref7","doi-asserted-by":"publisher","first-page":"801586","DOI":"10.3389\/fbioe.2022.801586","article-title":"Extremity compartment syndrome: a review with a focus on non-invasive methods of diagnosis","volume":"10","author":"Novak","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026051605040912700_ref8","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/00005131-200207000-00014","article-title":"Delayed presentation of acute compartment syndrome after contusion of the thigh","volume":"16","author":"Mith\u00f6fer","year":"2002","journal-title":"J Orthop Trauma"},{"key":"2026051605040912700_ref9","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing soft-tissue 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