{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T10:50:52Z","timestamp":1782384652758,"version":"3.54.5"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyroid hemiagenesis is a rare congenital anomaly characterized by the complete absence or underdevelopment of one thyroid lobe, resulting in the presence of only a single functional thyroid lobe. We present a unique case of a 34-year-old male patient who had congenital thyroid hemiagenesis and multi-nodular goiter. This case contributes to the existing medical literature by shedding light on the association between thyroid hemiagenesis and multi-nodular goiter. The patient experienced symptoms of right thyroid swelling and compression, and clinical examination revealed an enlarged right thyroid lobe with normal thyroid hormone and vitamin D3 levels. Ultrasound imaging showed an enlarged right lobe with multiple solid nodules, and fine needle aspiration cytology raised suspicion of a follicular neoplasm. Hemithyroidectomy confirmed the presence of a non-invasive follicular neoplasm. The case underscores the significance of comprehensive evaluation and surgical management in accurately diagnosing and treating thyroid hemiagenesis, which can be associated with many of thyroid disorders.<\/jats:p>","DOI":"10.1093\/jscr\/rjag441","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:37:35Z","timestamp":1779190655000},"source":"Crossref","is-referenced-by-count":0,"title":["Congenital thyroid hemiagenesis associated with follicular neoplasm: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Loai Saleh","family":"Albinsaad","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, King Faisal University , Al-Ahsa City, Eastern Province 31982, Prince Faisal Bin Fahad Bin Abdulaziz Road, Al-Hofuf, Al-Ahsa ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7171-1166","authenticated-orcid":false,"given":"Fatimah A","family":"Aldarisi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Faisal University , Al-Ahsa City, Eastern Province 31982, Prince Faisal Bin Fahad Bin Abdulaziz Road, Al-Hofuf, Al-Ahsa ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7773-9280","authenticated-orcid":false,"given":"Saud A","family":"Alwayil","sequence":"additional","affiliation":[{"name":"College of Medicine, King Faisal University , Al-Ahsa City, Eastern Province 31982, Prince Faisal Bin Fahad Bin Abdulaziz Road, Al-Hofuf, Al-Ahsa ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M","family":"Alsakkak","sequence":"additional","affiliation":[{"name":"College of Medicine, King Faisal University , Al-Ahsa City, Eastern Province 31982, Prince Faisal Bin Fahad Bin Abdulaziz Road, Al-Hofuf, Al-Ahsa ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5170-2483","authenticated-orcid":false,"given":"Nada I","family":"Almarzooq","sequence":"additional","affiliation":[{"name":"College of Medicine, King Faisal University , Al-Ahsa City, Eastern Province 31982, Prince Faisal Bin Fahad Bin Abdulaziz Road, Al-Hofuf, Al-Ahsa ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"2026062506244801100_ref1","doi-asserted-by":"publisher","first-page":"3124","DOI":"10.1210\/jc.2017-00784","article-title":"Thyroid hemiagenesis: incidence, clinical significance, and genetic background","volume":"102","author":"Szczepanek-Parulska","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2026062506244801100_ref2","author":"Sanctis","year":"2016"},{"key":"2026062506244801100_ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22401","volume":"14","author":"Lesi","year":"2022"},{"key":"2026062506244801100_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/2047981614530286","volume":"3","author":"Bhartiya","year":"2014","journal-title":"Acta Radiol Short Rep"},{"key":"2026062506244801100_ref5","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1080\/00015458.2005.11679774","article-title":"Multinodular goitre with thyroid hemiagenesis: a case report and review of the literature","volume":"105","author":"Aslaner","year":"2005","journal-title":"Acta Chir Belg"},{"key":"2026062506244801100_ref6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1507\/endocrj.50.409","article-title":"Thyroid hemiagenesis with multinodular goiter: a case report and review of the literature","volume":"50","author":"Karabay","year":"2003","journal-title":"Endocr J"},{"key":"2026062506244801100_ref7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000084568","article-title":"A singular case of Graves\u2019 disease in congenital thyroid hemiagenesis","volume":"63","author":"Baldini","year":"2005","journal-title":"Horm Res"},{"key":"2026062506244801100_ref8","doi-asserted-by":"publisher","first-page":"385","DOI":"10.14740\/jmc2189w","article-title":"A case of thyroid hemiagenesis associated with Graves\u2019 disease and follicular neoplasm","volume":"6","author":"Kim","year":"2015","journal-title":"J Med Cases"},{"key":"2026062506244801100_ref9","doi-asserted-by":"publisher","first-page":"e23087","DOI":"10.7759\/cureus.23087","article-title":"Hypothyroidism in thyroid hemiagenesis: a case report","volume":"14","author":"Shah","year":"2022","journal-title":"Cureus"},{"key":"2026062506244801100_ref10","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1002\/ccr3.3856","article-title":"Thyroid hemiagenesis with primary hyperparathyroidism or papillary thyroid carcinoma: a report of two cases and literature review","volume":"9","author":"Alqahtani","year":"2021","journal-title":"Clin Case Reports"},{"key":"2026062506244801100_ref11","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.3390\/ijms23063414","article-title":"NKX2-5 variant in two siblings with thyroid hemiagenesis","volume":"23","author":"Szczepanek-Parulska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026062506244801100_ref12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s12020-020-02422-1","article-title":"Compound heterozygous GLI3 variants in siblings with thyroid hemiagenesis","volume":"71","author":"Szczepanek-Parulska","year":"2021","journal-title":"Endocrine"},{"key":"2026062506244801100_ref13","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1089\/thy.2016.0662","article-title":"Prevalence and characterization of thyroid hemiagenesis in Japan: the Fukushima health management survey","volume":"27","author":"Suzuki","year":"2017","journal-title":"Thyroid"},{"key":"2026062506244801100_ref14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s10354-020-00783-w","article-title":"Hemiagenesis of the thyroid gland detected by coincidence-what is the clinical relevance?\u00a0Case report and review of the literature","volume":"170","author":"Mikosch","year":"2020","journal-title":"Wien Med Wochenschr"},{"key":"2026062506244801100_ref15","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1210\/JC.2007-2215","article-title":"Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage","volume":"93","author":"Haymart","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2026062506244801100_ref16","doi-asserted-by":"publisher","first-page":"e253843","DOI":"10.1136\/BCR-2022-253843","article-title":"Colloid nodular goitre associated with hemiagenesis of the thyroid gland","volume":"17","author":"Sadhasivan","year":"2024","journal-title":"BMJ Case Rep"},{"key":"2026062506244801100_ref17","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/S00423-014-1228-0","article-title":"Surgical strategy for primary hyperparathyreoidism with thyroid hemiagenesis","volume":"399","author":"Ferrari","year":"2014","journal-title":"Langenbecks Arch Surg"},{"key":"2026062506244801100_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-017-1250-0","volume":"15","author":"","year":"2017"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/6\/rjag441\/68610449\/rjag441.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/6\/rjag441\/68610449\/rjag441.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T10:25:05Z","timestamp":1782383105000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag441\/8704821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag441","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,31]]},"article-number":"rjag441"}}