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Surgery plays a major role as the initial treatment for locally advanced disease, followed by adjuvant chemotherapy, since most of the cases present in the advanced stage. Despite this, the overall prognosis is reported to be worse, with a median survival of 9 to 14\u00a0months. This is a case of an aggressive large cell neuroendocrine carcinoma of the right colon treated with upfront surgery followed by adjuvant chemotherapy.<\/jats:p>","DOI":"10.1093\/jscr\/rjag493","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:42:15Z","timestamp":1784202135000},"source":"Crossref","is-referenced-by-count":0,"title":["Aggressive large cell neuroendocrine carcinoma of the right colon: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-3532","authenticated-orcid":false,"given":"Andrej","family":"Nikolovski","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery, University Surgery Hospital \u201cSt. Naum Ohridski\u201d , 1000 Skopje ,","place":["North Macedonia"]},{"name":"Ss. Cyril and Methodius University in Skopje , 1000 Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-5266","authenticated-orcid":false,"given":"Shqipe","family":"Misimi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Kavaja Hospital , H4XJ+X39, 10510 Hajvali, Prishtina, Republic of Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Spirov","sequence":"additional","affiliation":[{"name":"Ss. Cyril and Methodius University in Skopje , 1000 Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-9119","authenticated-orcid":false,"given":"Blagica","family":"Krsteska","sequence":"additional","affiliation":[{"name":"Ss. Cyril and Methodius University in Skopje , 1000 Skopje ,","place":["North Macedonia"]},{"name":"Faculty of Medicine, Institute of Pathology , 1000 Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panche","family":"Zdravkovski","sequence":"additional","affiliation":[{"name":"Ss. Cyril and Methodius University in Skopje , 1000 Skopje ,","place":["North Macedonia"]},{"name":"Faculty of Medicine, Institute of Pathology , 1000 Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognen","family":"Kostovski","sequence":"additional","affiliation":[{"name":"Ss. Cyril and Methodius University in Skopje , 1000 Skopje ,","place":["North Macedonia"]},{"name":"University Clinic Digestive Surgery, Clinical Center \u201cMother Theresa\u201d , 1000 Skopje ,","place":["North Macedonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026072018032960800_ref1","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1245\/s10434-019-07203-3.Survival","article-title":"Survival in patients with high-grade colorectal neuroendocrine carcinomas: the role of surgery and chemotherapy","volume":"26","author":"Fields","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"2026072018032960800_ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jne.13309","article-title":"European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for colorectal neuroendocrine tumours","volume":"35","author":"Rinke","year":"2023","journal-title":"J 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