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The first case involved a 58-year-old female with obstructing rectal SRCC and extensive pelvic invasion with adnexal metastasis. The second is a 45-year-old male with an obstructing splenic flexure SRCC and peritoneal dissemination, found to have microsatellite instability and multiple oncogenic alterations. Both cases required aggressive surgical intervention and illustrate the need for individualized, multimodal treatment strategies. Colonic SRCC is an uncommon but highly aggressive malignancy that frequently presents at an advanced stage. Early recognition, comprehensive pathologic and molecular evaluation, and coordinated multimodal management are critical to optimizing outcomes.<\/jats:p>","DOI":"10.1093\/jscr\/rjag494","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:48:41Z","timestamp":1780573721000},"source":"Crossref","is-referenced-by-count":0,"title":["Management of two extremely aggressive signet ring cell colon carcinoma: a case series"],"prefix":"10.1093","volume":"2026","author":[{"given":"Nazila","family":"Dalir","sequence":"first","affiliation":[{"name":"Department of Surgery, Jersey Shore University Medical Center , 1945 NJ-33, Neptune City, NJ 07753,","place":["United States"]},{"name":"St. George\u2019s University School of Medicine , St. George\u2019s ,","place":["Grenada, West Indies"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn S","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jersey Shore University Medical Center , 1945 NJ-33, Neptune City, NJ 07753,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Amanda","family":"Masia","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jersey Shore University Medical Center , 1945 NJ-33, Neptune City, NJ 07753,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jersey Shore University Medical Center , 1945 NJ-33, Neptune City, NJ 07753,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026062506213904000_ref1","volume-title":"WHO Classification of Tumours of the Digestive 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