{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:47:48Z","timestamp":1782506868375,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastrointestinal stromal tumours (GISTs) rarely occur in young adults; in this age group, succinate dehydrogenase (SDH)-deficient subtypes predominate and may signal hereditary tumor syndromes. We present a 23-year-old male with a prior carotid paraganglioma who developed life-threatening iron deficiency anaemia (haemoglobin 4.0\u00a0g\/dl) as the presenting manifestation of a high-grade gastric GIST. Subtotal gastrectomy with Billroth II reconstruction achieved R0 resection. Molecular testing was negative for KIT and PDGFRA mutations. Given the patient\u2019s age, mixed epithelioid\/spindle histology, wild-type molecular profile, and paraganglioma history, Carney\u2013Stratakis syndrome was suspected. SDHB immunohistochemistry confirmed an SDH-deficient phenotype, and germline testing identified a pathogenic heterozygous SDHx variant, establishing the diagnosis of Carney\u2013Stratakis syndrome. At follow-up, the patient was clinically stable and enrolled in a multidisciplinary surveillance program. This case highlights the importance of recognizing atypical hematologic presentations of GIST and the need for comprehensive molecular and genetic evaluation in young patients.<\/jats:p>","DOI":"10.1093\/jscr\/rjag517","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:28:29Z","timestamp":1781004509000},"source":"Crossref","is-referenced-by-count":0,"title":["Gastric GIST with life-threatening anaemia and paraganglioma: a rare presentation of suspected Carney\u2013Stratakis syndrome in a young adult"],"prefix":"10.1093","volume":"2026","author":[{"given":"Nakul","family":"Ganju","sequence":"first","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwunonso","family":"Ndulue","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heera Tesfaye","family":"Erega","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarrah","family":"Fadul","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Santiago-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Aduli","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Shokrani","sequence":"additional","affiliation":[{"name":"Department of Surgery Gastroenterology, Howard University Hospital , 2041 Georgia Ave NW, Washington, DC 20060 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"2026062616093318000_ref1","first-page":"1","article-title":"Gastrointestinal stromal tumours","volume":"9","author":"Nishida","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"2026062616093318000_ref2","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1097\/PAS.0b013e3182260752","article-title":"Succinate dehydrogenase\u2013deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study","volume":"35","author":"Miettinen","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"2026062616093318000_ref3","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1001\/jamaoncol.2016.0256","article-title":"Molecular subtypes of GISTs and their therapeutic implications","volume":"2","author":"Boikos","year":"2016","journal-title":"JAMA 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GISTs","volume":"15","author":"Pantaleo","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026062616093318000_ref6","first-page":"1","article-title":"SDH-deficient GISTs: a clinicopathologic and molecular characterization","volume":"35","author":"Schaefer","year":"2022","journal-title":"Mod Pathol"},{"key":"2026062616093318000_ref7","first-page":"709","article-title":"Clinical, diagnostic, and treatment characteristics of SDH-deficient tumors","volume":"42","author":"Jha","year":"2021","journal-title":"Endocr Rev"},{"key":"2026062616093318000_ref8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/00000658-200001000-00008","article-title":"Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors","volume":"231","author":"Dematteo","year":"2000","journal-title":"Ann Surg"}],"container-title":["Journal of Surgical Case 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