{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:06:38Z","timestamp":1784138798453,"version":"3.55.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Typhoid fever is endemic in South Asia but often overlooked or misdiagnosed in non-endemic countries like the United Arab Emirates. Intestinal perforation is a rare but life-threatening complication, and growing fluoroquinolone resistance has made empirical management more challenging. A 39-year-old male ship worker presented with generalized peritonitis after recent travel to India and had received empirical ciprofloxacin without improvement. Imaging revealed pneumoperitoneum, and laparoscopy identified a single ileal perforation 30\u00a0cm proximal to the ileocecal junction, which was repaired. Blood and stool cultures confirmed ciprofloxacin-resistant Salmonella sensitive to trimethoprim-sulfamethoxazole and meropenem. He received 7 days of intravenous meropenem followed by oral Trimethoprim-Sulfamethoxazole, resulting in complete recovery. This case highlights the importance of considering typhoid in travelers with acute abdomen, even in non-endemic regions, and emphasizes culture-guided therapy and reassessment of empirical antibiotics amid rising resistance.<\/jats:p>","DOI":"10.1093\/jscr\/rjag557","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T17:20:50Z","timestamp":1784136050000},"source":"Crossref","is-referenced-by-count":0,"title":["Fluoroquinolone-resistant\n                    <i>Salmonella Typhi<\/i>\n                    presenting as ileal perforation in a traveler"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2708-8938","authenticated-orcid":false,"given":"Mohammad Aamir Qayyum Sarguroh","family":"Khan","sequence":"first","affiliation":[{"name":"Sheikh Khalifa Medical City , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Abdel Naser H","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1640-1020","authenticated-orcid":false,"given":"Gyanendra","family":"Jora","sequence":"additional","affiliation":[{"name":"KIST Medical College & Teaching Hospital , Lalitpur ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2362-564X","authenticated-orcid":false,"given":"Aafreen Ali","family":"Nyaz","sequence":"additional","affiliation":[{"name":"NMC Royal Hospital, Khalifa City , Abu Dhabi 35233 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Omran","family":"Khalil","sequence":"additional","affiliation":[{"name":"Al-Quds University , Jerusalem ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema Abdulsalam","family":"Alfahim","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zubair","family":"Khalid","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-5045","authenticated-orcid":false,"given":"Joaquin Salvelio Picazo","family":"Yeste","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026071513204048800_ref1","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.4269\/ajtmh.20-1448","article-title":"Case report: typhoid fever complicated by ileal perforation in an urban slum of Dhaka","volume":"104","author":"Khanam","year":"2021","journal-title":"Bangladesh Am J Trop Med Hyg"},{"key":"2026071513204048800_ref2","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.4103\/2141-9248.121220","article-title":"Typhoid intestinal perforation: 24 perforations in one patient","volume":"3","author":"Sharma","year":"2013","journal-title":"Ann Med Health Sci Res"},{"key":"2026071513204048800_ref3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid fever","volume":"50","author":"Crump","year":"2010","journal-title":"Clin Infect 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