{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:21Z","timestamp":1783660401917,"version":"3.55.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a rare tumor that is often difficult to diagnose preoperatively because of nonspecific symptoms and atypical imaging findings. Accurate identification is important, as ITPN carries a significant risk of associated invasive carcinoma. We report a case of ITPN with carcinoma in a 30-year-old man who presented with recurrent alcoholic pancreatitis, pancreatic pseudocysts, and a pancreatic duct stricture. Distal pancreatectomy revealed ITPN with invasive carcinoma. He received adjuvant FOLFIRINOX, but developed locally recurrent adenocarcinoma 17\u00a0months later, requiring completion total pancreatectomy. Postoperative therapy included chemoradiation with gemcitabine, nab-paclitaxel, and capecitabine, and on maintenance gemcitabine two years after the second surgery. This case illustrates the diagnostic and therapeutic challenges of ITPN in young adults and underscores the need to distinguish it from more common pancreatic diseases. Notably, carcinoma arising from ITPN may have a more favorable prognosis than conventional pancreatic ductal adenocarcinoma.<\/jats:p>","DOI":"10.1093\/jscr\/rjag558","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:17:45Z","timestamp":1783657065000},"source":"Crossref","is-referenced-by-count":0,"title":["Invasive adenocarcinoma associated with intraductal tubulopapillary neoplasm in young adult mimicking alcoholic pancreatitis and pseudocysts"],"prefix":"10.1093","volume":"2026","author":[{"given":"David","family":"Nolte","sequence":"first","affiliation":[{"name":"Department of Pathology, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeomachukwu E","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Arif","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khreiss","sequence":"additional","affiliation":[{"name":"Department of Surgery, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achyut K","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-2206","authenticated-orcid":false,"given":"Belinda L","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Banner-University Medical Center, College of Medicine, University of Arizona , 1625 N Campbell Ave, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026071000173485300_ref1","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1097\/PAS.0b013e3181a162e5","article-title":"Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"33","author":"Yamaguchi","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"2026071000173485300_ref2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/SLA.0000000000001173","article-title":"Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: recommendations of Verona consensus meeting","volume":"263","author":"Adsay","year":"2016","journal-title":"Ann Surg"},{"key":"2026071000173485300_ref3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","journal-title":"Histopathology"},{"key":"2026071000173485300_ref4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/PAS.0000000000000782","article-title":"Intraductal tubulopapillary neoplasm of the pancreas: a clinicopathologic and immunohistochemical analysis of 33 cases","volume":"41","author":"Basturk","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2026071000173485300_ref5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.5152\/dir.2019.18215","article-title":"Multimodality imaging studies of intraductal tubulopapillary neoplasms of the pancreas","volume":"25","author":"Kim","year":"2019","journal-title":"Diagn Interv Radiol"},{"key":"2026071000173485300_ref6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1080\/0284186X.2021.2016949","article-title":"Age and prognosis in patients with pancreatic cancer: a population-based study","volume":"61","author":"Dongen","year":"2022","journal-title":"Acta Oncol"},{"key":"2026071000173485300_ref7","doi-asserted-by":"publisher","first-page":"e14426","DOI":"10.1097\/MD.0000000000014426","article-title":"Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas: two case reports and literature review","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"2026071000173485300_ref8","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/modpathol.2017.60","article-title":"Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma","volume":"30","author":"Basturk","year":"2017","journal-title":"Mod Pathol"},{"key":"2026071000173485300_ref9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3892\/mco.2017.1216","article-title":"Intraductal tubulopapillary neoplasm accompanied by invasive carcinoma of the pancreas: a case report and review of the literature","volume":"6","author":"Niu","year":"2017","journal-title":"Mol Clin Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/7\/rjag558\/68741688\/rjag558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/7\/rjag558\/68741688\/rjag558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:17:45Z","timestamp":1783657065000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag558\/8729450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag558","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"rjag558"}}