{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:21Z","timestamp":1783660401879,"version":"3.55.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oral pyogenic granuloma (OPG) is a benign vascular proliferation that presents as a solitary, pedunculated, or sessile lesion, associated with irritative factors. Various systemic disorders, particularly type 2 diabetes mellitus (DM2), may contribute to its onset and progression through inflammatory and endothelial mechanisms. This clinical case report describes a 63-year-old male with a history of controlled hypertension and DM2 with glycated hemoglobin (HbA1c) of 7.97%, diagnosed with stage III, grade C generalized periodontitis. Therapeutic management began with periodontal phase I, including personalized oral hygiene instructions and scaling and root planning. After re-evaluation at 5\u00a0weeks, an excisional biopsy of the hyperplastic lesion was performed. Histopathological analysis confirmed OPG. The postoperative course was favorable, with proper healing at 15\u00a0days. Recent studies indicate that T2DM exacerbates periodontal inflammation through advanced glycation end-products and receptor for advanced glycation end-products (RAGE) signaling, accelerating OPG progression. Multidisciplinary approaches, including glycemic optimization, improve outcomes in these comorbidities.<\/jats:p>","DOI":"10.1093\/jscr\/rjag560","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:17:51Z","timestamp":1783657071000},"source":"Crossref","is-referenced-by-count":0,"title":["Exacerbated oral pyogenic granuloma in type 2 diabetes mellitus and advanced periodontitis: clinical management and pathophysiological insights: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Francisco Javier","family":"Alcaraz-Baturoni","sequence":"first","affiliation":[{"name":"Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Paola","family":"Ibarra-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Pathology, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Alberto","family":"Alarc\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Medicine Program, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]},{"name":"Institute of Research in Dentistry, Department of Integral Dental Clinics, University Center of Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ortu\u00f1o-Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroimmunobiology, Institute of Translational Neurosciences, Department of Molecular Biology and Genomics, University Center for Health Sciences, University of Guadalajara (CUCS-UdeG) , Calle Sierra Mojada 950, Colonia Independencia, Guadalajara 44340, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University , Chennai 600077 ,","place":["India"]},{"name":"Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi , Str. Koryun 2, Yerevan 0025 ,","place":["Armenia"]},{"name":"Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences , North Karegar St, Tehran \u00a0","place":["1439955591, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Gonz\u00e1lez-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center, University of Guadalajara (CUCIENEGA-UdeG) , Avenida Universidad 1115, Colonia Lindavista, Ocotl\u00e1n 47810, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Monserrat","family":"Lomel\u00ed-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Medical and Life Sciences, La Ci\u00e9nega University Center, University of Guadalajara (CUCIENEGA-UdeG) , Avenida Universidad 1115, Colonia Lindavista, Ocotl\u00e1n 47810, Jalisco ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026071000174630700_ref1","doi-asserted-by":"publisher","first-page":"S999","DOI":"10.4103\/jpbs.jpbs_703_23","article-title":"Oral pyogenic granuloma at different spots: a series of case reports","volume":"16","author":"Phull","year":"2024","journal-title":"J Pharm Bioallied Sci"},{"key":"2026071000174630700_ref2","doi-asserted-by":"publisher","first-page":"e49326","DOI":"10.7759\/cureus.49326","article-title":"A persistent oral pyogenic granuloma: a case report with review of literature","volume":"15","author":"Alshuhail","year":"2023","journal-title":"Cureus"},{"key":"2026071000174630700_ref3","doi-asserted-by":"publisher","first-page":"rjag100","DOI":"10.1093\/jscr\/rjag100","article-title":"Multifactorial etiology of oral pyogenic granuloma: case reports with distinct triggers","volume":"2026","author":"Alcaraz-Baturoni","year":"2026","journal-title":"J Surg Case Rep"},{"key":"2026071000174630700_ref4","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.12998\/wjcc.v11.i16.3907","article-title":"Unusual clinical presentation of oral pyogenic granuloma with severe alveolar bone loss: a case report and review of literature","volume":"11","author":"Lomel\u00ed Mart\u00ednez","year":"2023","journal-title":"World J Clin Cases"},{"key":"2026071000174630700_ref5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/njms.NJMS_55_18","article-title":"Heterogeneous conceptualization of etiopathogenesis: oral pyogenic granuloma","volume":"10","author":"Sharma","year":"2019","journal-title":"Natl J Maxillofac Surg"},{"key":"2026071000174630700_ref6","first-page":"12","article-title":"Granuloma Piog\u00eanico: Relato de Caso Cl\u00ednico","volume":"9","author":"Moraes","year":"2013","journal-title":"Rev Gest\u00e3o Sa\u00fade"},{"key":"2026071000174630700_ref7","doi-asserted-by":"publisher","first-page":"e84713","DOI":"10.7759\/cureus.84713","article-title":"Oral pyogenic granuloma in a child: suspected hormonal and traumatic factors, clinical features, and surgical management","volume":"17","author":"Daoudi","year":"2025","journal-title":"Cureus"},{"key":"2026071000174630700_ref8","doi-asserted-by":"publisher","first-page":"16885","DOI":"10.3390\/ijms242316885","article-title":"Oral pyogenic granuloma: a narrative review","volume":"24","author":"Lomeli Martinez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026071000174630700_ref9","doi-asserted-by":"publisher","first-page":"e48305","DOI":"10.7759\/cureus.48305","article-title":"An overview of oral pyogenic granuloma and its management: a case report","volume":"15","author":"Meshram","year":"2023","journal-title":"Cureus"},{"key":"2026071000174630700_ref10","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10266-022-00759-9","article-title":"Diode laser versus sclerotherapy: bloodless approaches in the treatment of oral pyogenic granuloma (randomised controlled clinical trial)","volume":"111","author":"Anwar","year":"2023","journal-title":"Odontology"},{"key":"2026071000174630700_ref11","doi-asserted-by":"publisher","first-page":"8269221","DOI":"10.1155\/2022\/8269221","article-title":"Comparative evaluation of efficacy and safety of the diode laser (980\u2009nm) and sclerotherapy for the treatment of oral pyogenic granuloma","volume":"2022","author":"Shivhare","year":"2022","journal-title":"Int J Dent"},{"key":"2026071000174630700_ref12","doi-asserted-by":"publisher","first-page":"e6160","DOI":"10.1097\/GOX.0000000000006160","article-title":"Pyogenic granuloma diagnosis and management: a practical review","volume":"12","author":"Kaleeny","year":"2024","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026071000174630700_ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.64471\/11sh1n75","article-title":"Pyogenic granuloma as reactive gingival overgrowth in an atypical mandibular location: a case report","volume":"3","author":"Hanif","year":"2026","journal-title":"J Basic Clin Dent"},{"key":"2026071000174630700_ref14","doi-asserted-by":"publisher","first-page":"CD004714","DOI":"10.1002\/14651858.CD004714.pub4","article-title":"Treatment of periodontitis for glycaemic control in people with diabetes mellitus","volume":"4","author":"Simpson","year":"2022","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/7\/rjag560\/68741744\/rjag560.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/7\/rjag560\/68741744\/rjag560.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:17:52Z","timestamp":1783657072000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag560\/8729456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag560","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"rjag560"}}