{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:07:33Z","timestamp":1784221653489,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autologous fat grafting (AFG) is widely used to refine contour and volume following breast reconstruction. However, its use in previously irradiated fields carries a higher risk of complications and poses diagnostic challenges in excluding locoregional recurrence. We report an unusual early inflammatory reaction following AFG into an irradiated Deep Inferior Epigastric Perforator flap-reconstructed breast, characterized by florid indurated, erythematous nodules within the fat-grafted native chest wall skin that clinically mimicked cancer recurrence. The lesions resolved with conservative management, and the patient uneventfully underwent further stages of lipofilling for symmetry. We postulate that the reaction represents an exaggerated inflammatory response to injected fat within a radiation-damaged microenvironment, a phenomenon not previously described in native irradiated breast skin following AFG. This case highlights an unreported complication of AFG and the diagnostic challenges it may pose. Clinicians should maintain a high index of suspicion and biopsy and image any suspicious lesion in these patients.<\/jats:p>","DOI":"10.1093\/jscr\/rjag597","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:46:34Z","timestamp":1784220394000},"source":"Crossref","is-referenced-by-count":0,"title":["Florid inflammatory reaction after fat grafting into an irradiated DIEP-reconstructed breast mimicking cancer recurrence"],"prefix":"10.1093","volume":"2026","author":[{"given":"Manasseh","family":"Tamakloe","sequence":"first","affiliation":[{"name":"Plastic Surgery Department, Nuffield Health Cambridge Hospital , 4 Trumpington Rd, Cambridge CB2 8AF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Omar","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7818-1572","authenticated-orcid":false,"given":"Krzysztof","family":"Sosnowski","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, University of Cambridge , Hills Rd, Cambridge CB20SP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Russell","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Nuffield Health Cambridge Hospital , 4 Trumpington Rd, Cambridge CB2 8AF ,","place":["United Kingdom"]},{"name":"Department of Radiotherapy, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]},{"name":"Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parto","family":"Forouhi","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Nuffield Health Cambridge Hospital , 4 Trumpington Rd, Cambridge CB2 8AF ,","place":["United Kingdom"]},{"name":"Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M","family":"Malata","sequence":"additional","affiliation":[{"name":"Plastic Surgery Department, Nuffield Health Cambridge Hospital , 4 Trumpington Rd, Cambridge CB2 8AF ,","place":["United Kingdom"]},{"name":"Plastic Surgery Department, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]},{"name":"Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Rd, Cambridge CB2 0QQ ,","place":["United Kingdom"]},{"name":"Anglia Ruskin University School of Medicine , Anglia Ruskin University, East Rd, Cambridge CB1 1PT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026071612462843200_ref1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1097\/01.prs.0000252001.59162.c9","article-title":"Fat grafting to the breast revisited: safety and efficacy","volume":"119","author":"Coleman","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"2026071612462843200_ref2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/J.BJPS.2023.09.026","article-title":"Timing of autologous fat grafting in implant-based breast reconstruction: best practices based on systematic review and meta-analysis","volume":"86","author":"Maheta","year":"2023","journal-title":"J Plast Reconstr Aesthet 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