{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:03:01Z","timestamp":1785344581840,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metastasis of oropharyngeal squamous cell carcinoma (OPSCC) to the thyroid gland is rare, and p16-positive cases form an even smaller subset. We present a case of p16-positive thyroid metastasis from OPSCC identified after complete treatment response. Nine months after completing chemoradiotherapy, the patient developed throat pain and hoarseness. Computed tomography demonstrated an enlarged heterogeneous right thyroid gland and fine needle aspiration confirmed p16-positive metastatic OPSCC in the absence of locoregional recurrence. The patient underwent extended total thyroidectomy and right selective neck dissection; formal pathology confirmed metastatic OPSCC with involved margins and 13\/22 positive lymph nodes. To our knowledge, this is the first reported intrathyroidal metastasis from p16-positive OPSCC after complete treatment response and in the absence of local recurrence. Further cases are required to better understand the epidemiology, optimal management, and prognosis of this presentation.<\/jats:p>","DOI":"10.1093\/jscr\/rjag642","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:34:37Z","timestamp":1784028877000},"source":"Crossref","is-referenced-by-count":0,"title":["p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-3342","authenticated-orcid":false,"given":"William H","family":"Cook","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, University of Cambridge , Cambridge ,","place":["United Kingdom"]},{"name":"Department of Surgery, University of Auckland , Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas A","family":"Linjawi","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Cambridge , Cambridge ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"van Dijck","sequence":"additional","affiliation":[{"name":"Department of ORL Head and Neck Surgery, North Shore Hospital , Auckland ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026072912485476100_ref1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/cncr.31841","article-title":"The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status","volume":"125","author":"Faraji","year":"2019","journal-title":"Cancer"},{"key":"2026072912485476100_ref2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/hed.21974","article-title":"p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency","volume":"34","author":"El-Naggar","year":"2012","journal-title":"Head Neck"},{"key":"2026072912485476100_ref3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1158\/1055-9965.EPI-04-0551","article-title":"Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review","volume":"14","author":"Kreimer","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026072912485476100_ref4","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/1097-0142(197206)29:6<1446::AID-CNCR2820290604>3.0.CO;2-C","article-title":"Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts","volume":"29","author":"Lindberg","year":"1972","journal-title":"Cancer"},{"key":"2026072912485476100_ref5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/1097-0142(19930115)71:2<452::AID-CNCR2820710228>3.0.CO;2-B","article-title":"Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma","volume":"71","author":"Leemans","year":"1993","journal-title":"Cancer"},{"key":"2026072912485476100_ref6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.oraloncology.2012.03.013","article-title":"Distant metastases from head and neck squamous cell carcinoma. 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