{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:03:21Z","timestamp":1785344601125,"version":"3.55.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anorectal malignant melanoma is a rare, notably aggressive malignancy, comprising fewer than 1% of all melanoma cases. Its early symptoms frequently resemble benign anorectal conditions, which may lead to diagnostic delays and poor outcomes. We report a case of a 42-year-old, previously healthy male who presented with a two-month history of progressive constipation, unintentional weight loss, and lower abdominal discomfort associated with melena. Imaging revealed a mass extending from the anal canal into the distal rectum, with hepatic metastases. Histopathological examination confirmed malignant melanoma with positive immunohistochemical staining for HMB-45 and Melan-A, and negative S-100. A diverting functional colostomy was performed for impending obstruction, and first-line nivolumab was initiated, but the patient deteriorated rapidly and died on best supportive care. This case highlights the silent nature of this malignancy and the importance of considering rare yet aggressive tumors when dealing with atypical or unexplained anorectal lesions.<\/jats:p>","DOI":"10.1093\/jscr\/rjag654","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:39:48Z","timestamp":1784374788000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary anorectal malignant melanoma with synchronous hepatic metastases in middle-aged patient: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Majed Khaled","family":"Alrudayni","sequence":"first","affiliation":[{"name":"Colorectal Consultant, Department of General Surgery, King Fahad Specialist Hospital , Buraydah, Qassim 51461 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-9013","authenticated-orcid":false,"given":"Nadir Ali","family":"Hilal","sequence":"additional","affiliation":[{"name":"Colorectal Consultant, Department of General Surgery, King Fahad Specialist Hospital , Buraydah, Qassim 51461 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan Abdullah","family":"Almurais","sequence":"additional","affiliation":[{"name":"General Surgery Specialist, Department of General Surgery, King Fahad Specialist Hospital , Buraydah, Qassim 51461 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi Suliman","family":"Aldhali","sequence":"additional","affiliation":[{"name":"General Surgery Specialist, Department of General Surgery, Military Hospital Buraydah , Qassim 52558 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Talea","family":"Almutairi","sequence":"additional","affiliation":[{"name":"General Surgery Resident, Department of General Surgery, King Fahad Specialist Hospital , Buraydah, Qassim 51461 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf Yahya","family":"Alyousef","sequence":"additional","affiliation":[{"name":"Medical Student, University of Tabuk, Faculty of Medicine Tabuk , Tabuk 71491 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026072912491601200_ref1","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.18632\/oncotarget.23835","article-title":"Anorectal mucosal melanoma","volume":"9","author":"Malaguarnera","year":"2018","journal-title":"Oncotarget"},{"key":"2026072912491601200_ref2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/CMR.0000000000001003","article-title":"Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma","volume":"34","author":"Paolino","year":"2024","journal-title":"Melanoma 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of anorectal melanoma in a 19-year-old female: a case report","volume":"132","author":"Saffaf","year":"2025","journal-title":"Int J Surg Case Rep"},{"key":"2026072912491601200_ref7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4314\/gmj.v56i4.12","article-title":"Anorectal malignant mucosal melanoma","volume":"56","author":"Bediako-Bowan","year":"2022","journal-title":"Ghana Med J"},{"key":"2026072912491601200_ref8","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.3390\/diagnostics15162086","article-title":"Anorectal malignant melanoma: diagnostic pitfalls and prognostic insights from a single-center retrospective analysis","volume":"15","author":"Haf\u0131zo\u011flu","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"2026072912491601200_ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15474","article-title":"A rare case of primary anorectal malignant 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