{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:44:46Z","timestamp":1786218286953,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Solid papillary carcinoma (SPC) of the breast is a rare neoplasm typically regarded as a low-grade tumor with indolent behavior. We report two cases of SPC in elderly women presenting with palpable breast masses. Preoperative imaging demonstrated BI-RADS 4 suspicious lesions, and ultrasound-guided core needle biopsy suggested a papillary neoplasm consistent with SPC. Definitive histopathological examination revealed SPC with unusual high-grade cytological features, including marked atypia, increased mitotic activity, and an elevated Ki-67 proliferation index, despite the absence of conventional invasive morphology in one case. These findings highlight a striking discordance between the typically indolent architectural appearance of SPC and cytological indicators of aggressive potential, underscoring the biological heterogeneity of this rare entity. Recognition of these atypical presentations is essential for accurate pathological diagnosis, risk stratification, and appropriate clinical management.<\/jats:p>","DOI":"10.1093\/jscr\/rjag688","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:46:01Z","timestamp":1785930361000},"source":"Crossref","is-referenced-by-count":0,"title":["Solid papillary carcinoma of the breast with high-grade cytological features: challenging the concept of indolence"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5037-6821","authenticated-orcid":false,"given":"Imane","family":"Tazi","sequence":"first","affiliation":[{"name":"Ibn Sina University Hospital Center, Pathology, National Institute of Oncology, Abderrahim Bouabid Avenue , Rabat 11000 ,","place":["Morocco"]},{"name":"Faculty of Medicine, Mohammed V University of Rabat , Rabat 11000, MA ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Ech-charif","sequence":"additional","affiliation":[{"name":"Ibn Sina University Hospital Center, Pathology, National Institute of Oncology, Abderrahim Bouabid Avenue , Rabat 11000 ,","place":["Morocco"]},{"name":"Faculty of Medicine, Mohammed V University of Rabat , Rabat 11000, MA ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-2828","authenticated-orcid":false,"given":"Ismail","family":"Boujida","sequence":"additional","affiliation":[{"name":"Ibn Sina University Hospital Center, Pathology, National Institute of Oncology, Abderrahim Bouabid Avenue , Rabat 11000 ,","place":["Morocco"]},{"name":"Faculty of Medicine, Mohammed V University of Rabat , Rabat 11000, MA ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Ibn Sina University Hospital Center, Pathology, National Institute of Oncology, Abderrahim Bouabid Avenue , Rabat 11000 ,","place":["Morocco"]},{"name":"Faculty of Medicine, Mohammed V University of Rabat , Rabat 11000, MA ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma","family":"El Khannoussi","sequence":"additional","affiliation":[{"name":"Ibn Sina University Hospital Center, Pathology, National Institute of Oncology, Abderrahim Bouabid Avenue , Rabat 11000 ,","place":["Morocco"]},{"name":"Faculty of Medicine, Mohammed V University of Rabat , Rabat 11000, MA ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"2026080815385542500_ref1","doi-asserted-by":"publisher","first-page":"e2021352","DOI":"10.4322\/acr.2021.352","article-title":"Solid papillary carcinoma of the breast","volume":"12","author":"Jadhav","year":"2022","journal-title":"Autops Case Rep"},{"key":"2026080815385542500_ref2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.breast.2015.12.015","article-title":"Solid papillary carcinoma of the breast: a special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment","volume":"26","author":"Guo","year":"2016","journal-title":"The Breast"},{"key":"2026080815385542500_ref3","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1097\/00000478-199511000-00003","article-title":"Solid papillary carcinoma of the breast. 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Results of immunohistochemical analysis and clinical follow-up","volume":"35","author":"Wynveen","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"2026080815385542500_ref11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/PAS.0b013e31821b3f65","article-title":"Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis","volume":"35","author":"Rakha","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"2026080815385542500_ref12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1159\/000517189","article-title":"Solid papillary carcinoma and encapsulated papillary carcinoma of the breast: clinical-pathologic features and basement membrane studies of 50 cases","volume":"88","author":"Morgan","year":"2021","journal-title":"Pathobiology"},{"key":"2026080815385542500_ref13","first-page":"e11172","article-title":"Solid papillary carcinoma of breast: clinicopathologic comparison with conventional ductal carcinoma of breast","volume":"12","author":"Hashmi","year":"2020","journal-title":"Cureus"},{"key":"2026080815385542500_ref14","first-page":"827","article-title":"Encapsulated papillary carcinoma and solid papillary carcinoma of the breast: comparison of clinicopathologic features and outcomes","volume":"78","author":"Papathomas","year":"2021","journal-title":"Histopathology"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag688\/70558994\/rjag688.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag688\/70558994\/rjag688.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:39:05Z","timestamp":1786217945000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag688\/8757003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag688","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"rjag688"}}