{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:06:31Z","timestamp":1789103191338,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vagal paragangliomas are rare neuroendocrine tumours of the vagus nerve. Surgery typically causes vagus nerve paralysis with impairments of voice and swallow, and sometimes long-term gastrostomy dependence. We report a series of seven patients who underwent resections of enlarging, benign, non-functional vagal paragangliomas at a tertiary centre with attempted nerve-fibre preservation. MD Anderson Dysphagia Inventory (MDADI) and University of Washington Quality of Life scores were obtained by telephone interviews of six patients. Nerve-fibre preservation was achieved in three patients (43%), versus 5% reported in published systematic reviews. The preservation group had superior swallowing (mean MDADI composite 91 versus 66) and quality of life. No patient required tracheostomy or gastrostomy, and no tumour recurrence was identified at a mean follow-up of 10.5 years (range 6.4\u201312.7). Nerve-fibre preservation, when anatomically feasible, may reduce surgical morbidity without compromising local tumour control. Regionalisation of paraganglioma care and multi-centre data are needed.<\/jats:p>","DOI":"10.1093\/jscr\/rjag695","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:38:42Z","timestamp":1784893122000},"source":"Crossref","is-referenced-by-count":0,"title":["Vagus nerve-fibre preservation during resection of vagal paraganglioma: a case series with patient-reported outcomes"],"prefix":"10.1093","volume":"2026","author":[{"given":"Madeline","family":"Leadon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Ovenell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-6370","authenticated-orcid":false,"given":"Jonathan M","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital , London W6 8RF ,","place":["United Kingdom"]},{"name":"Department of Surgery and Cancer, Imperial College London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2026091100244091600_ref1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0022215123001615","article-title":"Head and neck cancer: United Kingdom national multidisciplinary guidelines, sixth edition","volume":"138","author":"Homer","year":"2024","journal-title":"J Laryngol Otol"},{"key":"2026091100244091600_ref2","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1288\/00005537-199404000-00008","article-title":"Glomus vagale: paraganglioma of the vagus nerve","volume":"104","author":"Urquhart","year":"1994","journal-title":"Laryngoscope"},{"key":"2026091100244091600_ref3","doi-asserted-by":"publisher","first-page":"5210","DOI":"10.1210\/jcem.86.11.8034","article-title":"Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients","volume":"86","author":"Erickson","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2026091100244091600_ref4","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.bbabio.2011.07.003","article-title":"SDH mutations in cancer","volume":"1807","author":"Bardella","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2026091100244091600_ref5","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1002\/hed.24871","article-title":"Feasibility of a wait-and-scan period as initial management strategy for head and neck paraganglioma","volume":"39","author":"Jansen","year":"2017","journal-title":"Head Neck"},{"key":"2026091100244091600_ref6","first-page":"482","article-title":"Vagal paraganglioma: the Jefferson experience","volume":"122","author":"Miller","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2026091100244091600_ref7","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1002\/hed.22976","article-title":"Jugular and vagal paragangliomas: systematic study of management with surgery and radiotherapy","volume":"35","author":"Su\u00e1rez","year":"2013","journal-title":"Head Neck"},{"key":"2026091100244091600_ref8","first-page":"870","article-title":"The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. 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Anderson dysphagia inventory","volume":"127","author":"Chen","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2026091100244091600_ref9","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1001\/archotol.124.10.1133","article-title":"Vagal paraganglioma: a review of 46 patients treated during a 20-year period","volume":"124","author":"Netterville","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2026091100244091600_ref10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/humu.21136","article-title":"Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD","volume":"31","author":"Ricketts","year":"2010","journal-title":"Hum Mutat"},{"key":"2026091100244091600_ref11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12881-014-0111-8","article-title":"Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations","volume":"15","author":"Bayley","year":"2014","journal-title":"BMC Med Genet"},{"key":"2026091100244091600_ref12","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1136\/jmedgenet-2017-105127","article-title":"Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB SDHC and SDHD","volume":"55","author":"Andrews","year":"2018","journal-title":"J Med Genet"},{"key":"2026091100244091600_ref13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00405-013-2384-5","article-title":"Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy","volume":"271","author":"Su\u00e1rez","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag695\/71023391\/rjag695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag695\/71023391\/rjag695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:24:49Z","timestamp":1789100689000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag695\/8790241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag695","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,31]]},"article-number":"rjag695"}}