{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:27:08Z","timestamp":1786757228286,"version":"build-2736575974"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple giant mediastinal liposarcomas are rare and associated with a high propensity for recurrence. Surgical management is extremely challenging and carries substantial risks. Here we report the case of a 40-year-old male patient who underwent multiple surgical resections for mediastinal liposarcoma. In April 2016, the patient presented with an intrathoracic mass and underwent right thoracotomy at our institution; postoperative histopathology confirmed a myxoid liposarcoma. Over the following decade, the patient received six cycles of chemotherapy and two cycles of anlotinib. In 2025, due to progressive dyspnea and chest tightness, chest computed tomography revealed multiple giant masses in the mediastinum and pleural cavity. In December 2025, the patient underwent resection of mediastinal tumors via a left seventh intercostal thoracotomy, followed by another resection via a right seventh intercostal thoracotomy in April 2026. Postoperative recovery was uneventful.<\/jats:p>","DOI":"10.1093\/jscr\/rjag708","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:50:03Z","timestamp":1786189803000},"source":"Crossref","is-referenced-by-count":0,"title":["Multiple surgical excision for bilateral multiple mediastinal liposarcoma: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Suxin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University , Yangzhou ,","place":["China"]},{"name":"The First School of Clinical Medicine, Faculty of Medicine, Yangzhou University , Yangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University , Yangzhou ,","place":["China"]},{"name":"The First School of Clinical Medicine, Faculty of Medicine, Yangzhou University , Yangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jienong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University , Yangzhou ,","place":["China"]},{"name":"The First School of Clinical Medicine, Faculty of Medicine, Yangzhou University , Yangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Air Force Medical Center, PLA, the Fourth Military Medical University , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University , Yangzhou ,","place":["China"]},{"name":"The First School of Clinical Medicine, Faculty of Medicine, Yangzhou University , Yangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"2026081420461179900_ref1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1200\/JCO.2017.74.9598","article-title":"Clinical and molecular spectrum of liposarcoma","volume":"36","author":"Lee","year":"2018","journal-title":"J Clin Oncol"},{"key":"2026081420461179900_ref2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/0218492318772763","article-title":"Successful resection of a giant thoracic myxoid liposarcoma","volume":"26","author":"Pui","year":"2018","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2026081420461179900_ref3","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.36611","article-title":"Primary dedifferentiated liposarcoma of the posterior mediastinum with a positive surgical margin","author":"Yoshino","year":"2023","journal-title":"Cureus"},{"key":"2026081420461179900_ref4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16223858","article-title":"Liposarcoma: a journey into a rare Tumor\u2019s epidemiology, diagnosis, pathophysiology, and limitations of current therapies","volume":"16","author":"Jonczak","year":"2024","journal-title":"Cancers"},{"key":"2026081420461179900_ref5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijscr.2018.07.037","article-title":"An unusual case of recurrent huge primary mediastinal dedifferentiated liposarcoma","volume":"50","author":"Soeroso","year":"2018","journal-title":"Int J Surg Case Rep"},{"key":"2026081420461179900_ref6","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.70495","article-title":"Giant lipoma-like liposarcoma of the mediastinum: a rare case of acute respiratory failure","volume":"13","author":"Giovannico","year":"2025","journal-title":"Clinical Case Reports"},{"key":"2026081420461179900_ref7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.18295\/squmj.12.2022.064","article-title":"Giant mediastinal myxoid pleomorphic liposarcoma","volume":"23","author":"Kindi","year":"2023","journal-title":"Sultan Qaboos Univ Med J"},{"key":"2026081420461179900_ref8","doi-asserted-by":"crossref","DOI":"10.1186\/s13019-024-03245-1","article-title":"Thoracoscopic resection of primary mediastinal liposarcoma: a case report and literature review","volume":"20","author":"Yang","year":"2025","journal-title":"J Cardiothorac Surg"},{"key":"2026081420461179900_ref9","article-title":"Extracorporeal membrane oxygenation with robotic-assisted thoracic surgery for treatment of giant mediastinal liposarcoma","volume":"29","author":"Villa Sanchez","year":"2024","journal-title":"JACC: Case Rep"}],"container-title":["Journal of Surgical Case 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