{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:22:25Z","timestamp":1787458945564,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cockayne syndrome (CS) is a rare autosomal recessive transcription-coupled nucleotide excision repair disorder (ERCC6\/ERCC8) causing progressive neuromuscular deterioration and limb contractures. We report a 10-year-old boy with CS type B (ERCC6) who presented with rigid bilateral equinovarus, rendering him non-ambulatory, and elevated transaminases (ALT 682\u00a0U\/L, AST 183\u00a0U\/L). Bilateral fractional elongation of the Achilles tendon was performed successfully; hepatotoxic agents were avoided, and opioid\/sedative dosages were meticulously titrated. Recovery was uneventful; the patient regained supported standing and resumed active physiotherapy. Functional orthopedic surgery is achievable in CS via rigorous multidisciplinary coordination, providing a valuable template for perioperative risk management.<\/jats:p>","DOI":"10.1093\/jscr\/rjag732","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:44:07Z","timestamp":1785843847000},"source":"Crossref","is-referenced-by-count":0,"title":["Surgical correction of severe rigid equinovarus deformity in Cockayne syndrome: perioperative challenges and multidisciplinary management\u2014a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Shadi Abu","family":"Isneina","sequence":"first","affiliation":[{"name":"Orthopaedics Department, Palestine Polytechnic University , Wadi Al Haria, PO Box 198, Hebron ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2936-5073","authenticated-orcid":false,"given":"Bessan Hamed","family":"Dababseh","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Wadi Al Haria, PO Box 198, Hebron ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7781-4645","authenticated-orcid":false,"given":"Ala\u2019a S","family":"Ghnimat","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Wadi Al Haria, PO Box 198, Hebron ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6365-0311","authenticated-orcid":false,"given":"Lubna W","family":"AbuHamdiya","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Wadi Al Haria, PO Box 198, Hebron ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6098-7489","authenticated-orcid":false,"given":"Dina","family":"Wohoosh","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Wadi Al Haria, PO Box 198, Hebron ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2703-3809","authenticated-orcid":false,"given":"Abdallah","family":"Dababsseh","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine, Alexandria University , 22 El-Guish Road, El-Shatby, Alexandria 21526 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"2026082300184783400_ref1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/humu.21154","article-title":"Mutation update for the CSB\/ERCC6 and CSA\/ERCC8 genes involved in Cockayne syndrome","volume":"31","author":"Laugel","year":"2010","journal-title":"Hum Mutat"},{"key":"2026082300184783400_ref2","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.mad.2009.07.006","article-title":"Neuropathology of Cockayne syndrome: evidence for impaired development, premature aging, and neurodegeneration","volume":"130","author":"Weidenheim","year":"2009","journal-title":"Mech Ageing Dev"},{"key":"2026082300184783400_ref3","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.ajhg.2013.04.007","article-title":"Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia","volume":"92","author":"Kashiyama","year":"2013","journal-title":"Am J Hum Genet"},{"key":"2026082300184783400_ref4","doi-asserted-by":"publisher","first-page":"e8970","DOI":"10.1097\/MD.0000000000008970","article-title":"Are parents of children with Cockayne syndrome manifesting features of the disorder? Case reports","volume":"96","author":"Al Kaissi","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"2026082300184783400_ref5","volume-title":"GeneReviews\u00ae [Internet]","author":"Laugel","year":"1993"},{"key":"2026082300184783400_ref6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.14740\/jmc2913w","article-title":"Perioperative care of a pediatric patient with Cockayne syndrome","volume":"8","author":"Khawaja","year":"2017","journal-title":"J Med Cases"},{"key":"2026082300184783400_ref7","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.1073\/pnas.0902113106","article-title":"A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage","volume":"106","author":"Nardo","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026082300184783400_ref8","first-page":"259","article-title":"Progressive neurodegeneration in Cockayne syndrome: report of a family","volume":"21","author":"Bertola","year":"2006","journal-title":"J Child Neurol"},{"key":"2026082300184783400_ref9","first-page":"27","article-title":"Medium-term follow-up of Achilles tendon lengthening in the treatment of ankle equinus in cerebral palsy","volume":"26","author":"Dietz","year":"2006","journal-title":"Iowa Orthop J"},{"key":"2026082300184783400_ref10","doi-asserted-by":"publisher","first-page":"1143292","DOI":"10.3389\/fphys.2023.1143292","article-title":"Quantifying the effects of Achilles tendon lengthening surgery: an intraoperative approach","volume":"14","author":"Brendecke","year":"2023","journal-title":"Front Physiol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag732\/70765173\/rjag732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag732\/70765173\/rjag732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:18:54Z","timestamp":1787458734000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag732\/8768853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag732","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"rjag732"}}