{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:22:26Z","timestamp":1787458946563,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malignant phyllodes tumor is a rare and aggressive breast neoplasm with the potential for rapid and recurrent growth. We present the case of a 56-year-old woman from San Mart\u00edn, Peru, with a left breast mass exhibiting exponential growth, ulceration, necrosis, and asymmetry. Physical examination revealed a multinodular, purplish-red, indurated, and slightly painful mass. Ultrasound showed a 12-cm hypoechoic, heterogeneous mass with areas of necrosis, increased vascularity, and contact with the muscle layer (Breast Imaging Reporting and Data System category 4). Core biopsy revealed a fibroepithelial neoplasm with high mitotic activity (10\/10 HPF). The patient underwent left total mastectomy with subsequent margin extension and partial-thickness skin grafting, achieving complete resection and satisfactory recovery. This case highlights the challenges in the diagnosis and surgical management of this pathology in resource-limited settings where timely surgery plays a crucial role in treatment and prevents recurrence.<\/jats:p>","DOI":"10.1093\/jscr\/rjag735","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:55:48Z","timestamp":1786017348000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical case giant malignant phyllodes tumor of the breast"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3743-2443","authenticated-orcid":false,"given":"Alan Hari Silva","family":"Amaya","sequence":"first","affiliation":[{"name":"Department of Surgery and Specialties, Oncological Surgery Service , Hospital II-2 Tarapoto, San Mart\u00edn ,","place":["Peru"]},{"name":"Faculty of Human Medicine, National University of San Mart\u00edn , Tarapoto ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6100-2356","authenticated-orcid":false,"given":"Julio Caleb Arrieta","family":"Navarro","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, National University of San Mart\u00edn , Tarapoto ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-0954","authenticated-orcid":false,"given":"\u00c1lvaro M","family":"\u00d1a\u00f1a-C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, Scientific University of the South , Lima ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-3440","authenticated-orcid":false,"given":"Elkin J","family":"Pel\u00e1ez-Cruz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, National University of Trujillo , La Libertad ,","place":["Peru"]},{"name":"Scientific Society of Medical Students of the National University of Trujillo , La Libertad ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4325-4374","authenticated-orcid":false,"given":"Sorely Pacovilca","family":"Chura","sequence":"additional","affiliation":[{"name":"Faculty of Human Medicine, Peruvian Union University , Lima ,","place":["Peru"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"2026082300185764800_ref1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/his.14091","volume-title":"WHO Classification of Tumors of the Breast","author":"Tan","year":"2019","edition":"5"},{"key":"2026082300185764800_ref2","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1002\/cncr.22228","article-title":"Malignant phyllodes tumor of the female breast: treatment outcomes","volume":"107","author":"Macdonald","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"2026082300185764800_ref3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.32074\/1591-951X-754","article-title":"Malignant phyllodes tumor of the breast: a systematic review","volume":"114","author":"Lissidini","year":"2022","journal-title":"Pathologica"},{"key":"2026082300185764800_ref4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.breast.2009.03.001","article-title":"Phyllodes tumours of the breast: a clinicopathological analysis of 65 cases from a single institution","volume":"18","author":"Karim","year":"2009","journal-title":"Breast"},{"key":"2026082300185764800_ref5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4274\/ejbh.galenos.2023.2023-3-2","article-title":"Management and outcomes of metastatic and recurrent malignant phyllodes tumors of the breast: a systematic literature review","volume":"19","author":"Samii","year":"2023","journal-title":"Eur J Breast Health"},{"key":"2026082300185764800_ref6","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1245\/s10434-019-07210-4","article-title":"Long-term outcomes after surgical treatment of malignant\/borderline phyllodes tumors of the breast","volume":"26","author":"Spanheimer","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"2026082300185764800_ref7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.21037\/abs-20-99","article-title":"Diagnosis and management of phyllodes tumors of the breast","volume":"5","author":"Simpson","year":"2021","journal-title":"Ann Breast Surg"},{"key":"2026082300185764800_ref8","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1245\/s10434-019-07445-1","article-title":"Predicting outcome in mammary phyllodes tumors: relevance of clinicopathological features","volume":"26","author":"Li","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"2026082300185764800_ref9","doi-asserted-by":"publisher","first-page":"2919922","DOI":"10.1155\/tbj\/2919922","article-title":"Primary breast malignancy in children and adolescents: a population-based study","volume":"2024","author":"He","year":"2024","journal-title":"Breast J"},{"key":"2026082300185764800_ref10","doi-asserted-by":"publisher","first-page":"106969","DOI":"10.1016\/j.ijsu.2022.106969","article-title":"Management of phyllodes tumor: a systematic review and meta-analysis of real-world evidence","volume":"107","author":"Yu","year":"2022","journal-title":"Int J Surg"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag735\/70765240\/rjag735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag735\/70765240\/rjag735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:19:03Z","timestamp":1787458743000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag735\/8768862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag735","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"rjag735"}}