{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:17:43Z","timestamp":1787793463078,"version":"build-2784847793"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dedifferentiated liposarcoma (DDL) is a rare malignant mesenchymal tumor affecting predominantly the retroperitoneum. Complete surgical excision following early diagnosis is crucial in these patients due to a high rate of local recurrence and metastasis. We report a rare case of synchronous retroperitoneal and mesenteric DDL presenting both a diagnostic and therapeutic challenge.<\/jats:p>","DOI":"10.1093\/jscr\/rjag744","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:51:03Z","timestamp":1786017063000},"source":"Crossref","is-referenced-by-count":0,"title":["Synchronous retroperitoneal and mesenteric dedifferentiated liposarcoma: case report of a challenging rare disease and literature review"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-6861","authenticated-orcid":false,"given":"Mauro","family":"Giambusso","sequence":"first","affiliation":[{"name":"Department of Surgery, General Surgery Operative Unit, Umberto I Hospital , Contrada Ferrante, 94100 Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-7880","authenticated-orcid":false,"given":"Paolo","family":"Di Mattia","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna \u201cKore\u201d , Contrada Ferrante, 94100 Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8040","authenticated-orcid":false,"given":"Giorgio Maria Paolo","family":"Graziano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna \u201cKore\u201d , Contrada Ferrante, 94100 Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Licciardello","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Surgery Operative Unit, Umberto I Hospital , Contrada Ferrante, 94100 Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Corrado","family":"Centonze","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Surgery Operative Unit, Umberto I Hospital , Contrada Ferrante, 94100 Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"2026082620221073300_ref1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1053\/j.semdp.2019.02.006","article-title":"Well-differentiated liposarcoma and dedifferentiated liposarcoma: an updated review","volume":"36","author":"Thway","year":"2019","journal-title":"Semin Diagn Pathol"},{"key":"2026082620221073300_ref2","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1186\/s12885-024-13021-y","article-title":"Dedifferentiated liposarcoma of the extremities: a Korean multi-center study of 107 cases","volume":"24","author":"Park","year":"2024","journal-title":"BMC Cancer"},{"key":"2026082620221073300_ref3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/jso.24929","article-title":"Multiply recurrent retroperitoneal liposarcoma","volume":"117","author":"Bagaria","year":"2018","journal-title":"J Surg Oncol"},{"key":"2026082620221073300_ref4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1200\/JCO.2017.74.9598","article-title":"Clinical and molecular spectrum of liposarcoma","volume":"36","author":"Lee","year":"2018","journal-title":"J Clin Oncol"},{"key":"2026082620221073300_ref5","doi-asserted-by":"publisher","first-page":"e2022121","DOI":"10.23750\/abm.v92iS1.12010","article-title":"Well-differentiated mesenteric liposarcoma: report of two cases","volume":"92","author":"Poillucci","year":"2022","journal-title":"Acta Biomed"},{"key":"2026082620221073300_ref6","doi-asserted-by":"publisher","first-page":"2632010X221112455","DOI":"10.1177\/2632010X221112455","article-title":"Dedifferentiated liposarcoma: a rare case report of retroperitoneal myxoid soft tissue tumour with diagnostic dilemma","volume":"15","author":"Chaudhary","year":"2022","journal-title":"Clin Pathol"},{"key":"2026082620221073300_ref7","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.1016\/j.radcr.2022.08.005","article-title":"Giant mesenteric myxoid liposarcoma: challenges of diagnosis and treatment","volume":"17","author":"Mokfi","year":"2022","journal-title":"Radiol Case Rep"},{"key":"2026082620221073300_ref8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1053\/j.semdp.2019.02.007","article-title":"Pleomorphic liposarcoma: updates and current differential diagnosis","volume":"36","author":"Anderson","year":"2019","journal-title":"Semin Diagn Pathol"},{"key":"2026082620221073300_ref9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/medsci14020275","article-title":"Liposarcoma: state of the art-a scoping review","volume":"14","author":"Caraban","year":"2026","journal-title":"Med Sci (Basel)"},{"key":"2026082620221073300_ref10","doi-asserted-by":"publisher","first-page":"e38329","DOI":"10.7759\/cureus.38329","article-title":"A rare case of primary mesenteric liposarcoma","volume":"15","author":"Ahire","year":"2023","journal-title":"Cureus"},{"key":"2026082620221073300_ref11","doi-asserted-by":"publisher","first-page":"102846","DOI":"10.1016\/j.ctrv.2024.102846","article-title":"Diagnosis and management of dedifferentiated liposarcoma: a multidisciplinary position statement","volume":"131","author":"Haddox","year":"2024","journal-title":"Cancer Treat Rev"},{"key":"2026082620221073300_ref12","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1093\/ajcp\/aqab051","article-title":"Retroperitoneal dedifferentiated liposarcoma","volume":"156","author":"Dehner","year":"2021","journal-title":"Am J Clin Pathol"},{"key":"2026082620221073300_ref13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11864-020-0705-7","article-title":"Dedifferentiated liposarcoma: systemic therapy options","volume":"21","author":"Gahvari","year":"2020","journal-title":"Curr Treat Options Oncol"},{"key":"2026082620221073300_ref14","doi-asserted-by":"publisher","first-page":"117204","DOI":"10.1016\/j.biopha.2024.117204","article-title":"Molecular characteristics and systemic treatment options of liposarcoma: a systematic review","volume":"178","author":"Zhou","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026082620221073300_ref15","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1080\/14656566.2019.1618271","article-title":"Pharmacotherapy for liposarcoma: current state of the art and emerging systemic treatments","volume":"20","author":"Suarez-Kelly","year":"2019","journal-title":"Expert Opin Pharmacother"},{"key":"2026082620221073300_ref16","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.2217\/fon-2020-1092","article-title":"Pharmacotherapy for liposarcoma: current and emerging synthetic treatments","volume":"17","author":"Chamberlain","year":"2021","journal-title":"Future Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag744\/70811149\/rjag744.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/8\/rjag744\/70811149\/rjag744.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:22:19Z","timestamp":1787790139000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag744\/8771510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag744","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"rjag744"}}