{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:26:11Z","timestamp":1788456371667,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hidradenoma papilliferum (HAP) is a rare benign adnexal tumor of apocrine differentiation, typically occurring in the vulvar or perianal region of women. We report an exceptionally rare case of HAP arising from the lacrimal caruncle, with only one similar case previously documented in the ophthalmic literature. A 61-year-old woman presented with a 3-month history of a painless, vascularized reddish mass over the right caruncle. Complete surgical excision was performed without complications. Histopathological examination revealed a well-circumscribed lesion with papillary and glandular architecture, fibrovascular cores, and a characteristic bilayered epithelium with apocrine features, consistent with HAP and without evidence of malignancy. This case highlights the importance of considering HAP in the differential diagnosis of caruncular tumors and confirms surgical excision as curative.<\/jats:p>","DOI":"10.1093\/jscr\/rjag789","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:51:19Z","timestamp":1787140279000},"source":"Crossref","is-referenced-by-count":0,"title":["Hidradenoma papilliferum of the caruncle: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Amer","family":"Alemam","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye Specialty Hospital , Al-Madina Al-Monawara St., Tla Al-Ali, PO Box 1494, Amman 11821 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husam","family":"Khaleel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Specialty Hospital , Al-Madina Al-Monawara St., Tla Al-Ali, PO Box 1494, Amman 11821 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadeer","family":"Almuhaisen","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Mutah University Mutah , Mutah Street, PO Box 7, Al-Karak 61710 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9211-1616","authenticated-orcid":false,"given":"Ayman","family":"Musleh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye Specialty Hospital , Al-Madina Al-Monawara St., Tla Al-Ali, PO Box 1494, Amman 11821 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2953-2188","authenticated-orcid":false,"given":"Hashem Abu","family":"Serhan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hamad Medical Corporation , Al Rayyan, Zone 37, Street 15, PO Box 3050, Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"2026090312540293500_ref1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1467-2494.2007.00387.x","article-title":"A short history of sweat gland biology","volume":"29","author":"Wilke","year":"2007","journal-title":"Int J Cosmet Sci"},{"key":"2026090312540293500_ref2","author":"Brar","journal-title":"2025-2026 BCSC Basic and Clinical Science Course, Section 2: Fundamentals and Principles of Ophthalmology"},{"key":"2026090312540293500_ref3","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1097\/DAD.0000000000000495","article-title":"Hidradenoma papilliferum: a clinicopathologic study of 264 tumors from 261 patients, with emphasis on mammary-type alterations","volume":"38","author":"Konstantinova","year":"2016","journal-title":"American Journal of Dermatopathology"},{"key":"2026090312540293500_ref4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0190-9622(99)70418-4","article-title":"Ectopic hidradenoma papilliferum: a case report and review of the literature","volume":"41","author":"Vang","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"2026090312540293500_ref5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.amsu.2019.11.002","article-title":"Hidradenoma papilliferum of the external auditory canal","volume":"49","author":"Laababsi","year":"2020","journal-title":"Case Report Annals of Medicine and Surgery"},{"key":"2026090312540293500_ref6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1001\/archderm.1981.01650010061028","article-title":"Hidradenoma papilliferum of the eyelid","volume":"117","author":"Santa Cruz","year":"1981","journal-title":"Arch Dermatol"},{"key":"2026090312540293500_ref7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.survophthal.2014.01.002","article-title":"Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin","volume":"59","author":"Jakobiec","year":"2014","journal-title":"Surv Ophthalmol"},{"key":"2026090312540293500_ref8","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1097\/IOP.0b013e31825238ae","article-title":"Hidradenoma papilliferum presenting as an eyelid mass","volume":"28","author":"Jain","year":"2012","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2026090312540293500_ref9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.sjopt.2009.10.005","article-title":"Periocular hidradenoma papilliferum","volume":"23","author":"Al-Faky","year":"2009","journal-title":"Saudi Journal of Ophthalmology"},{"key":"2026090312540293500_ref10","doi-asserted-by":"publisher","first-page":":709371","DOI":"10.1155\/2010\/709371","article-title":"Ectopic hidradenoma papilliferum","volume":"2010","author":"Rosmaninho","year":"2010","journal-title":"Dermatol Res Pract"},{"key":"2026090312540293500_ref11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3109\/01676830.2012.739673","article-title":"Hidradenoma papilliferum of the orbit","volume":"32","author":"Katz","year":"2013","journal-title":"Orbit"},{"key":"2026090312540293500_ref12","doi-asserted-by":"publisher","first-page":"1000513","DOI":"10.4172\/2165-7920.1000513","article-title":"Hidradenoma papilliferum of the caruncle","volume":"05","author":"Alkatan MA, Akaishi P, Cruz AAV.","year":"2015","journal-title":"J Clin Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag789\/70947133\/rjag789.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag789\/70947133\/rjag789.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:54:11Z","timestamp":1788454451000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag789\/8784990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag789","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,31]]},"article-number":"rjag789"}}