{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:05:31Z","timestamp":1789736731010,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary retroperitoneal sarcomas (RPS) are rare, with leiomyosarcoma (LMS) being the second most common subtype. While open surgery is the standard of care, total laparoscopic resection for large RPS remains technically challenging and infrequently reported. Herein, we present a rare case of a 60-year-old woman who presented with a 6-month history of dull abdominal pain. Computed tomography revealed a large 10\u00a0cm retroperitoneal mass initially mimicking a duodenal gastrointestinal stromal tumour. The patient underwent a successful totally laparoscopic en bloc R0 resection with uneventful recovery. Histopathology and immunohistochemistry confirmed LMS (Actin and Desmin positive; CD117, CD34, DOG1, \u03b2-catenin, and S100 negative). Genetic analysis identified a rare TP53 G105R mutation (c.313G\u2009&amp;gt;\u2009C). Conclusion: Total laparoscopic R0 resection is a safe and feasible option for large LMS when performed by experienced surgical teams. Identifying rare molecular profiles provides deeper insights into the biological behaviour and personalized management of this rare disease.<\/jats:p>","DOI":"10.1093\/jscr\/rjag829","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:29:06Z","timestamp":1788521346000},"source":"Crossref","is-referenced-by-count":0,"title":["Total laparoscopic R0 resection of a large retroperitoneal leiomyosarcoma HARBORING a rare TP53 mutation: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Doi","family":"Van Mai","sequence":"first","affiliation":[{"name":"Department of General Surgery, Can Tho University of Medicine and Pharmacy Hospital, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]},{"name":"Department of General Surgery, Faculty of Medicine, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu Diep Thien","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Can Tho University of Medicine and Pharmacy Hospital, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Van Nguyen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Can Tho University of Medicine and Pharmacy Hospital, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]},{"name":"Department of General Surgery, Faculty of Medicine, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiet Gia","family":"Le Nguyen","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Can Tho University of Medicine and Pharmacy Hospital, Can Tho University of Medicine and Pharmacy , 179 Nguyen Van Cu Street, Tan An ward, Can Tho City ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"2026091808203188200_ref1","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s12672-025-03630-9","article-title":"Global trends in retroperitoneal sarcomas surgery: a bibliometric analysis from 2005 to 2024","volume":"16","author":"Zhang","year":"2025","journal-title":"Discov Oncol"},{"key":"2026091808203188200_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051293","article-title":"Retroperitoneal sarcoma care in 2021","volume":"14","author":"Schmitz","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026091808203188200_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zraf050","article-title":"Histology-driven tailoring of surgical approaches in retroperitoneal soft tissue sarcoma: retrospective cohort study","volume":"9","author":"Musa","year":"2025","journal-title":"BJS Open"},{"key":"2026091808203188200_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225469","article-title":"Retroperitoneal soft tissue sarcoma: emerging therapeutic strategies","volume":"15","author":"Bree","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026091808203188200_ref5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.21037\/cco.2018.07.05","article-title":"Surgical management of retroperitoneal sarcoma and opportunities for global collaboration","volume":"7","author":"Wang","year":"2018","journal-title":"Chin Clin Oncol"},{"key":"2026091808203188200_ref6","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.3390\/curroncol30050349","article-title":"Surgical management of retroperitoneal sarcoma","volume":"30","author":"Dominguez","year":"2023","journal-title":"Curr Oncol"},{"key":"2026091808203188200_ref7","doi-asserted-by":"publisher","first-page":"7873","DOI":"10.1245\/s10434-021-09654-z","article-title":"Management of primary retroperitoneal sarcoma (RPS) in the adult: an updated consensus approach from the transatlantic Australasian RPS working group","volume":"28","author":"Swallow","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"2026091808203188200_ref8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ijscr.2019.03.023","article-title":"Dedifferentiated retroperitoneal large liposarcoma and laparoscopic treatment: is it possible and safe? The first literature case report","volume":"57","author":"Agrusa","year":"2019","journal-title":"Int J Surg Case Rep"},{"key":"2026091808203188200_ref9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.7602\/jmis.2016.19.3.108","article-title":"Laparoscopic excision of a retroperitoneal solitary fibrous tumor: a case report","volume":"19","author":"Min","year":"2016","journal-title":"J Minimally Invasive Surg"},{"key":"2026091808203188200_ref10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.9738\/INTSURG-D-13-00076.1","article-title":"Laparoscopic resection of a retroperitoneal liposarcoma: a case report and review of the literature","volume":"98","author":"Nomura","year":"2013","journal-title":"Int Surg"},{"key":"2026091808203188200_ref11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174091","article-title":"Surgical principles of primary retroperitoneal sarcoma in the era of personalized treatment: a review of the frontline extended surgery","volume":"14","author":"Munoz","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026091808203188200_ref12","doi-asserted-by":"publisher","first-page":"omaf002","DOI":"10.1093\/omcr\/omaf002","article-title":"Unmasking the uncommon: retroperitoneal leiomyosarcoma case report","volume":"2025","author":"Imane","year":"2025","journal-title":"Oxf Med Case Reports"},{"key":"2026091808203188200_ref13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1477-7819-8-81","article-title":"Intraabdominal and retroperitoneal soft-tissue sarcomas--outcome of surgical treatment in primary and recurrent tumors","volume":"8","author":"Sogaard","year":"2010","journal-title":"World J Surg Oncol"},{"key":"2026091808203188200_ref14","doi-asserted-by":"publisher","first-page":"rjae460","DOI":"10.1093\/jscr\/rjae460","article-title":"Duplication cyst in adult cases: a journey from diagnosis to treatment","volume":"2024","author":"Van Pham","year":"2024","journal-title":"J Surg Case Rep"},{"key":"2026091808203188200_ref15","doi-asserted-by":"publisher","first-page":"100167","DOI":"10.1016\/j.soi.2025.100167","article-title":"Laparoscopic resection of a left retroperitoneal solitary fibrous tumor","volume":"2","author":"Benuzzi","year":"2025","journal-title":"Surg Oncol Insight"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag829\/71224638\/rjag829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag829\/71224638\/rjag829.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:20:42Z","timestamp":1789734042000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag829\/8817149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag829","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,31]]},"article-number":"rjag829"}}