{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:56:15Z","timestamp":1790646975199,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Laryngeal amyloidosis is a rare condition that may mimic benign, malignant or functional laryngeal disorders. We present a single-centre four-patient case series demonstrating clinical heterogeneity in anatomical distribution, amyloid typing, systemic association and management. All four cases were confirmed histologically. Two patients had localized AL laryngeal amyloidosis following specialist assessment, one patient had laryngotracheal amyloid deposition in the context of known multiple myeloma, and one patient had untyped laryngeal amyloidosis involving the bilateral ventricles and vocal cords. Management varied from conservative airway surveillance to endoscopic debridement, guided by symptom burden, anatomical extent, airway risk and systemic context. This series highlights that the value of reporting multiple cases lies not only in rarity, but in comparing consistent diagnostic principles with divergent disease behaviour and treatment pathways.<\/jats:p>","DOI":"10.1093\/jscr\/rjag854","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:06:56Z","timestamp":1789474016000},"source":"Crossref","is-referenced-by-count":0,"title":["Laryngeal amyloidosis: a single-centre four-patient case series highlighting diagnostic challenges and clinical heterogeneity"],"prefix":"10.1093","volume":"2026","author":[{"given":"Ruben Raj","family":"Ellan Govan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Ninewells Hospital, NHS Tayside , Ninewells Avenue, Dundee DD2 1GZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparajith","family":"Sathish Kumar","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Dundee , Ninewells Hospital, Ninewells Avenue, Dundee DD2 1GZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Rahmaan","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Dundee , Ninewells Hospital, Ninewells Avenue, Dundee DD2 1GZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ninewells Hospital, NHS Tayside , Ninewells Avenue, Dundee DD2 1GZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaiganesh Jai","family":"Manickavasagam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ninewells Hospital, NHS Tayside , Ninewells Avenue, Dundee DD2 1GZ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026092821045636700_ref1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1515\/med-2020-0400","article-title":"Focus on localized laryngeal amyloidosis: management of five cases","volume":"15","author":"Mesolella","year":"2020","journal-title":"Open Med (Wars)"},{"key":"2026092821045636700_ref2","doi-asserted-by":"publisher","first-page":"103550","DOI":"10.1016\/j.amjoto.2022.103550","article-title":"Localized laryngeal amyloidosis: a systematic review","volume":"43","author":"Pai","year":"2022","journal-title":"Am J Otolaryngol"},{"key":"2026092821045636700_ref3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.5005\/jp-journals-10001-1558","article-title":"Isolated laryngotracheal amyloidosis with rare clinical presentation and latest surgical management: case report and review of literature","volume":"14","author":"Satpathy","year":"2024","journal-title":"Int J Head Neck Surg"},{"key":"2026092821045636700_ref4","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.mayocp.2023.11.018","article-title":"Laryngeal amyloidosis","volume":"99","author":"Knoll","year":"2024","journal-title":"Mayo Clin Proc"},{"key":"2026092821045636700_ref5","doi-asserted-by":"publisher","first-page":"rjs005","DOI":"10.1093\/jscr\/rjs005","article-title":"Primary localized laryngeal amyloidosis presenting with dysphonia: a case report","volume":"2012","author":"Chow","year":"2012","journal-title":"J Surg Case Rep"},{"key":"2026092821045636700_ref6","doi-asserted-by":"publisher","first-page":"100695","DOI":"10.1016\/j.xocr.2025.100695","article-title":"Laryngeal amyloidosis mimicking neoplasia: a case treated by transoral CO2 laser excision","volume":"37","author":"Bouchlarhem","year":"2025","journal-title":"Otolaryngol Case Rep"},{"key":"2026092821045636700_ref7","doi-asserted-by":"publisher","first-page":"9049","DOI":"10.4076\/1752-1947-3-9049","article-title":"Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report","volume":"3","author":"Yiotakis","year":"2009","journal-title":"J Med Case Rep"},{"key":"2026092821045636700_ref8","doi-asserted-by":"publisher","first-page":"1002253","DOI":"10.3389\/fonc.2022.1002253","article-title":"Localized light chain amyloidosis: a self-limited plasmacytic B-cell lymphoproliferative disorder","volume":"12","author":"Mart\u00ednez","year":"2022","journal-title":"Front Oncol"},{"key":"2026092821045636700_ref9","doi-asserted-by":"publisher","first-page":"E1912","DOI":"10.1002\/lary.29320","article-title":"One hundred cases of localized laryngeal amyloidosis - evidence for future management","volume":"131","author":"Harris","year":"2021","journal-title":"Laryngoscope"},{"key":"2026092821045636700_ref10","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1007\/s00405-023-07881-6","article-title":"Surgical treatment of laryngeal amyloidosis: a systematic review","volume":"280","author":"Galluzzi","year":"2023","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag854\/71451344\/rjag854.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/9\/rjag854\/71451344\/rjag854.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:05:02Z","timestamp":1790643902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag854\/8842679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag854","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,31]]},"article-number":"rjag854"}}