{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:28:24Z","timestamp":1793777304705,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastric metastasis from breast cancer is rare and frequently misdiagnosed as primary gastric adenocarcinoma. Mixed ductal-lobular carcinoma demonstrates a unique metastatic pattern with a predilection for the gastrointestinal tract and serosal surfaces, creating significant diagnostic and therapeutic challenges. We describe a 77-year-old woman with a history of estrogen receptor\u2013positive breast carcinoma who presented 3 years after mastectomy with epigastric pain, vomiting, and weight loss. Endoscopy revealed a malignant-appearing gastric ulcer and initial histology suggested primary gastric adenocarcinoma with signet-ring features. However, immunohistochemical analysis (pan-CK, CK7, mammaglobin, ER, PR positivity with CK20 and CDX2 negativity) confirmed metastatic breast carcinoma. Operative findings revealed diffuse peritoneal and omental metastases. The patient underwent palliative gastrojejunostomy but developed severe postoperative complications and died on postoperative day 51. This case highlights the importance of immunohistochemistry and multidisciplinary evaluation to avoid unnecessary radical surgery in metastatic breast carcinoma.<\/jats:p>","DOI":"10.1093\/jscr\/rjag870","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:21:36Z","timestamp":1790425296000},"source":"Crossref","is-referenced-by-count":0,"title":["Gastric and peritoneal metastases from breast carcinoma with a mixed ductal-lobular phenotype and aberrant E-cadherin: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Hind S","family":"Al-Otaibi","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Kuwait Cancer Control Center (KCCC), Ministry of Health , Al-Sabah Medical District, PO Box 42262, Shuwaikh 70653 ,","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Kuwait Cancer Control Center (KCCC), Ministry of Health , Al-Sabah Medical District, PO Box 42262, Shuwaikh 70653 ,","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani","family":"AlBaqer","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Kuwait Cancer Control Center (KCCC), Ministry of Health , Al-Sabah Medical District, PO Box 42262, Shuwaikh 70653 ,","place":["Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrou","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kuwait Cancer Control Center (KCCC), Ministry of Health , Al-Sabah Medical District, PO Box 42262, Shuwaikh 70653 ,","place":["Kuwait"]},{"name":"Department of Clinical Oncology, Faculty of Medicine, Second Al Minya, Minia Governorate 2431436, Minia University ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Essam","family":"Abdulfattah","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Kuwait Cancer Control Center (KCCC), Ministry of Health , Al-Sabah Medical District, PO Box 42262, Shuwaikh 70653 ,","place":["Kuwait"]},{"name":"Department of Surgical Oncology, National Cancer Institute, Fom El Khalig Square, 1 Kasr El Eini Street, Cairo, 11796, Cairo University ,","place":["Egypt"]},{"name":"Department of Surgery, Institut Gustave Roussy , 114 rue \u00c9douard-Vaillant, 94805 Villejuif Cedex, France, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"2026110401425321600_ref1","doi-asserted-by":"publisher","first-page":"20211033","DOI":"10.1259\/bjr.20211033","article-title":"Understanding breast cancer as a global health concern","volume":"95","author":"Wilkinson","year":"2022","journal-title":"Br J Radiol"},{"key":"2026110401425321600_ref2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/sj.bjc.6602787","article-title":"Clinical characteristics of different histologic types of breast cancer","volume":"93","author":"Li","year":"2005","journal-title":"Br J Cancer"},{"key":"2026110401425321600_ref3","doi-asserted-by":"publisher","first-page":"26717","DOI":"10.1038\/s41598-025-12883-x","article-title":"Patterns and prognostic implications of distant metastasis in breast cancer based on SEER population data","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"2026110401425321600_ref4","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1245\/ASO.2005.03.030","article-title":"Breast cancer: presentation and intervention in women with gastrointestinal metastasis and carcinomatosis","volume":"12","author":"McLemore","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"2026110401425321600_ref5","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13256-026-05952-w","article-title":"Invasive lobular carcinoma of the breast with multifocal gastrointestinal, ovarian, and peritoneal metastases: a case report","volume":"20","author":"Karkeabadi","year":"2026","journal-title":"J Med Case Reports"},{"key":"2026110401425321600_ref6","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/s41416-022-02131-8","article-title":"Mixed invasive ductal lobular carcinoma is clinically and pathologically more similar to invasive lobular than ductal carcinoma","volume":"128","author":"Nasrazadani","year":"2023","journal-title":"Br J Cancer"},{"key":"2026110401425321600_ref7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/jso.24527","article-title":"Metastatic pattern of invasive lobular carcinoma of the breast\u2014emphasis on gastric metastases","volume":"115","author":"El-Hage","year":"2017","journal-title":"J Surg Oncol"},{"key":"2026110401425321600_ref8","doi-asserted-by":"publisher","first-page":"e6953","DOI":"10.1002\/ccr3.6953","article-title":"Invasive lobular carcinoma metastasis mimicking primary gastric signet ring cell carcinoma","volume":"11","author":"Jinushi","year":"2023","journal-title":"Clin Case Rep"},{"key":"2026110401425321600_ref9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13256-026-05864-9","article-title":"Metastatic breast cancer presenting with dyspeptic symptoms: a case report","volume":"20","author":"Bekai","year":"2026","journal-title":"J Med Case Reports"},{"key":"2026110401425321600_ref10","doi-asserted-by":"publisher","first-page":"e70881","DOI":"10.1002\/ccr3.70881","article-title":"Gastric metastases from invasive breast lobular carcinoma, identified by [18F]FDG PET\/CT, 20 years after primary diagnosis: a case report","volume":"13","author":"Ilonca","year":"2025","journal-title":"Clin Case Rep"},{"key":"2026110401425321600_ref11","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13000-025-01638-x","article-title":"Revisiting the use of CK7 and CK20 immunohistochemical stains in pathological diagnoses","volume":"20","author":"Wang","year":"2025","journal-title":"Diagn Pathol"},{"key":"2026110401425321600_ref12","first-page":"384","article-title":"Mammaglobin, a valuable diagnostic marker for metastatic breast carcinoma","volume":"2","author":"Wang","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"2026110401425321600_ref13","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1634\/theoncologist.2012-0350","article-title":"Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis","volume":"18","author":"Curtit","year":"2013","journal-title":"Oncologist"},{"key":"2026110401425321600_ref14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1365-2559.2012.04344.x","article-title":"GCDFP-15 and mammaglobin expression by immunohistochemistry is of limited utility in triple-negative breast cancer","volume":"62","author":"Huo","year":"2013","journal-title":"Histopathology"},{"key":"2026110401425321600_ref15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s00432-025-06222-w","article-title":"Hereditary diffuse gastric and lobular breast cancer syndrome associated with germline CDH1 variants: focus on lobular breast cancer","volume":"151","author":"Corso","year":"2025","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag870\/71577941\/rjag870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag870\/71577941\/rjag870.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:42:57Z","timestamp":1793774577000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag870\/8860375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag870","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,10]]},"article-number":"rjag870"}}