{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:28:34Z","timestamp":1793777314615,"version":"4.6.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Giant congenital melanocytic naevi (GCMN) presenting over large surface areas pose significant reconstructive challenges following surgical excision. We report the case of a paediatric female with a symptomatic GCMN covering ~2% of total body surface area on the right thigh, causing recurrent ulceration and psychological distress. Following failed conservative management, excision under general anaesthetic was performed, with reconstruction of the thigh defect using NovoSorb\u2122 Biodegradable Temporizing Matrix (BTM). Despite a series of sequential infectious and contamination episodes during integration\u2014including bacterial infection with Escherichia coli, Pseudomonas aeruginosa, and Klebsiella variicola, urine contamination, and maggot infestation\u2014BTM maintained integration with conservative management. Successful split-thickness skin grafting was achieved at 4 weeks, with complete wound healing at 4 months and a well-matured scar at 1 year. This case supports BTM as a robust option for paediatric GCMN reconstruction in anatomically challenging, high-contamination locations.<\/jats:p>","DOI":"10.1093\/jscr\/rjag875","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:26:59Z","timestamp":1789673219000},"source":"Crossref","is-referenced-by-count":0,"title":["NovoSorb\u2122 biodegradable temporizing matrix for post-excision wound reconstruction in a paediatric giant congenital melanocytic naevus: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Kelly Ka Yee","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Lister Hospital, East & North Hertfordshire NHS Trust , Coreys Mill Lane, Stevenage SG1 4AB ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calver","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Road, Cambridge CB2 2QQ ,","place":["United Kingdom"]},{"name":"Department of Surgical Biotechnology, Division of Surgery and Interventional Science, University College London , Gower Street, London WC1E 6BT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Foundation Trust , Hills Road, Cambridge CB2 2QQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"2026110401434045100_ref1","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/bjd.15301","article-title":"Melanoma in congenital melanocytic naevi","volume":"176","author":"Kinsler","year":"2017","journal-title":"Br J Dermatol"},{"key":"2026110401434045100_ref2","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.burns.2016.01.028","article-title":"Artificial dermal templates: a comparative study of NovoSorb\u2122 biodegradable temporising matrix (BTM) and integra\u00ae dermal regeneration template (DRT)","volume":"42","author":"Cheshire","year":"2016","journal-title":"Burns"},{"key":"2026110401434045100_ref3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.bjps.2009.01.050","article-title":"Giant naevus, giant excision, eleg(i)ant closure? Reconstructive surgery with integra artificial skin to treat giant congenital melanocytic naevi in children","volume":"63","author":"Schiestl","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2026110401434045100_ref4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/00006534-200109010-00004","article-title":"Giant congenital nevi: a 20-year experience and an algorithm for their management","volume":"108","author":"Gosain","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"2026110401434045100_ref5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cps.2024.09.003","article-title":"Congenital melanocytic nevi","volume":"52","author":"Nathan","year":"2025","journal-title":"Clin Plast Surg"},{"key":"2026110401434045100_ref6","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1136\/adc.84.2.152","article-title":"Central nervous system imaging and congenital melanocytic naevi","volume":"84","author":"Kinsler","year":"2001","journal-title":"Arch Dis Child"},{"key":"2026110401434045100_ref7","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1097\/00006534-200104010-00005","article-title":"Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children","volume":"107","author":"Foster","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"2026110401434045100_ref8","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1016\/j.bjps.2020.05.067","article-title":"A consecutive case series of defects reconstructed using NovoSorb\u00ae biodegradable temporising matrix: initial experience and early results","volume":"73","author":"Solanki","year":"2020","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2026110401434045100_ref9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/DSS.0000000000003966","article-title":"Biodegradable temporizing matrix for the reconstruction of a pyoderma gangrenosum wound","volume":"50","author":"Prasidha","year":"2024","journal-title":"Dermatol Surg"},{"key":"2026110401434045100_ref10","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/DSS.0000000000003933","article-title":"Reconstruction of a large extramammary Paget disease pelvic defect","volume":"50","author":"Gearing","year":"2024","journal-title":"Dermatol Surg"},{"key":"2026110401434045100_ref11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.burnso.2023.03.002","article-title":"The versatility of biodegradable temporising matrix: a 63 paediatric case series with complex wounds","volume":"7","author":"Storey","year":"2023","journal-title":"Burns Open"},{"key":"2026110401434045100_ref12","doi-asserted-by":"publisher","first-page":"e70025","DOI":"10.1111\/iwj.70025","article-title":"Biodegradable temporising matrix in the reconstruction of complex wounds: a systematic review and meta-analysis","volume":"21","author":"Lane","year":"2024","journal-title":"Int Wound J"},{"key":"2026110401434045100_ref13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.burnso.2017.08.001","article-title":"Experience with a synthetic bilayer biodegradable temporising matrix in significant burn injury","volume":"2","author":"Greenwood","year":"2018","journal-title":"Burns Open"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag875\/71577950\/rjag875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag875\/71577950\/rjag875.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:43:46Z","timestamp":1793774626000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag875\/8860376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag875","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,10]]},"article-number":"rjag875"}}