{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:44:55Z","timestamp":1792032295250,"version":"4.4.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma strongly associated with textured breast implants; bilateral synchronous disease is exceptionally uncommon. We report a 51-year-old woman with 6\u00a0months of right breast swelling, 20\u00a0years after bilateral augmentation and 3 years after revision surgery. Imaging showed bilateral peri-implant effusions with irregular capsular thickening. Ultrasound-guided aspiration revealed malignant cells suspicious for high-grade lymphoma, and staging positron emission tomography-computed tomography (PET-CT) showed no distant disease. The patient underwent bilateral en-bloc capsulectomy with removal of both implants. Using the tumor, node, metastasis staging system for BIA-ALCL, the disease was classified as T3N0M0 (Stage IC) bilaterally. Histopathology confirmed bilateral BIA-ALCL with CD30-positive, anaplastic lymphoma kinase (ALK)-negative cells. Postoperative PET-CT showed patchy metabolic activity, but biopsy confirmed a foreign body giant cell reaction without residual malignancy. Bilateral BIA-ALCL should be considered with late peri-implant effusion even when symptoms are unilateral, and suspicious postoperative PET-CT findings require histological confirmation.<\/jats:p>","DOI":"10.1093\/jscr\/rjag917","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:33:30Z","timestamp":1791286410000},"source":"Crossref","is-referenced-by-count":0,"title":["Bilateral breast implant-associated anaplastic large cell lymphoma presenting as late peri-implant effusion: a case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"Noof","family":"Al Shaibani","sequence":"first","affiliation":[{"name":"Surgical Oncology Department and Breast Unit, Bahrain Oncology Center , Road 2835, Block 228, Busaiteen 00228 ,","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gala","family":"Kaazan Moussallem","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department and Breast Unit, Bahrain Oncology Center , Road 2835, Block 228, Busaiteen 00228 ,","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naina","family":"Simon","sequence":"additional","affiliation":[{"name":"Histopathology Department, King Hamad University Hospital , Building 2435, Road 2835, Block 228, Busaiteen 00228,","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar R","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department and Breast Unit, Bahrain Oncology Center , Road 2835, Block 228, Busaiteen 00228 ,","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid A","family":"Al Sindi","sequence":"additional","affiliation":[{"name":"Histopathology Department, King Hamad University Hospital , Building 2435, Road 2835, Block 228, Busaiteen 00228,","place":["Bahrain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101422000423500_ref1","volume-title":"Breast Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019","edition":"5th"},{"key":"2026101422000423500_ref2","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/his.13932","article-title":"Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): an overview of presentation and pathogenesis and guidelines for pathological diagnosis and management","volume":"75","author":"Jones","year":"2019","journal-title":"Histopathology"},{"key":"2026101422000423500_ref3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/PRS.0000000000011370","article-title":"American Association of Plastic Surgeons consensus on breast implant-associated anaplastic large-cell lymphoma","volume":"154","author":"Clemens","year":"2024","journal-title":"Plast Reconstr Surg"},{"key":"2026101422000423500_ref4","author":"U.S. Food and Drug Administration","year":"2025"},{"key":"2026101422000423500_ref5","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/annonc\/mdv575","article-title":"Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes","volume":"27","author":"Laurent","year":"2016","journal-title":"Ann Oncol"},{"key":"2026101422000423500_ref6","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1097\/PRS.0000000000002010","article-title":"Bacterial biofilm infection detected in breast implant-associated anaplastic large-cell lymphoma","volume":"137","author":"Hu","year":"2016","journal-title":"Plast Reconstr Surg"},{"key":"2026101422000423500_ref7","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/asj\/sjv016","article-title":"Lymphomas associated with breast implants: a review of the literature","volume":"35","author":"Rupani","year":"2015","journal-title":"Aesthet Surg J"},{"key":"2026101422000423500_ref8","doi-asserted-by":"publisher","first-page":"e0181097","DOI":"10.1371\/journal.pone.0181097","article-title":"Cytological diagnostic features of late breast implant seromas: from reactive to anaplastic large cell lymphoma","volume":"12","author":"Di Napoli","year":"2017","journal-title":"PloS One"},{"key":"2026101422000423500_ref9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1200\/JCO.2015.63.3412","article-title":"Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma","volume":"34","author":"Clemens","year":"2016","journal-title":"J Clin Oncol"},{"key":"2026101422000423500_ref10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/asj\/sjw259","article-title":"NCCN consensus guidelines for the diagnosis and management of breast implant-associated anaplastic large cell lymphoma","volume":"37","author":"Clemens","year":"2017","journal-title":"Aesthet Surg J"}],"container-title":["Journal of Surgical Case 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