{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:44:56Z","timestamp":1792032296198,"version":"4.4.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myxofibrosarcoma (MFS) is a fibroblastic sarcoma that typically arises in the extremities of elderly patients; primary retroperitoneal involvement is exceptionally rare and often mimics myxoid liposarcoma. We report a 53-year-old man with a three-month history of progressive abdominal distension caused by a giant retroperitoneal mass measuring 26\u00a0cm. Core needle biopsy suggested a low-grade myxoid sarcoma, with myxoid liposarcoma not excluded. Multidisciplinary discussion led to en bloc left compartmental resection, including left colectomy, nephrectomy, adrenalectomy, and splenopancreatectomy. Histopathology confirmed a FNCLCC grade II myxoid sarcoma; fluorescence in situ hybridization showed no MDM2 amplification, confirming MFS and excluding dedifferentiated liposarcoma. The patient remained disease-free at 22\u00a0months. This case underscores the diagnostic overlap between retroperitoneal MFS and liposarcoma, the pivotal role of molecular pathology, and the importance of complete compartmental resection for local control.<\/jats:p>","DOI":"10.1093\/jscr\/rjag919","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:28:38Z","timestamp":1790425718000},"source":"Crossref","is-referenced-by-count":0,"title":["Giant primary retroperitoneal myxofibrosarcoma mimicking myxoid liposarcoma: a diagnostic and surgical challenge"],"prefix":"10.1093","volume":"2026","author":[{"given":"Amina","family":"Houmada","sequence":"first","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakaria","family":"El Mouatassim","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"El Bouazizi","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Reda","family":"El Hassouni","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumayma","family":"Lahnaoui","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Anass","family":"Majbar","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Souadka","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Surgery Department, Mohammed V Souissi University , Allal El Fassi Avenue, Rabat 10500, Rabat-Sal\u00e9-Zemmour-Za\u00ebr ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101422000410300_ref1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.soc.2022.03.001","article-title":"WHO pathology: highlights of the 2020 sarcoma update","volume":"31","author":"Schaefer","year":"2022","journal-title":"Surg Oncol Clin N Am"},{"key":"2026101422000410300_ref2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/00000658-199809000-00008","article-title":"Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution","volume":"228","author":"Lewis","year":"1998","journal-title":"Ann Surg"},{"key":"2026101422000410300_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/17588359221093973","article-title":"Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives","volume":"14","author":"Vanni","year":"2022","journal-title":"Ther Adv Med Oncol"},{"key":"2026101422000410300_ref4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1097\/00000478-199604000-00001","article-title":"Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant","volume":"20","author":"Mentzel","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"2026101422000410300_ref5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.humpath.2016.08.009","article-title":"Differential diagnosis of atypical lipomatous tumor\/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry","volume":"59","author":"Kammerer-Jacquet","year":"2017","journal-title":"Hum Pathol"},{"key":"2026101422000410300_ref6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/(SICI)1096-9896(199806)185:2&lt;188::AID-PATH53&gt;3.0.CO;2-2","article-title":"Molecular abnormalities in liposarcoma: role of MDM2 and CDK4-containing amplicons at 12q13-22","volume":"185","author":"Pilotti","year":"1998","journal-title":"J Pathol"},{"key":"2026101422000410300_ref7","doi-asserted-by":"publisher","first-page":"244","DOI":"10.14740\/wjon1528","article-title":"Giant retroperitoneal liposarcoma: correlation between size and risk for recurrence","volume":"13","author":"Marjiyeh-Awwad","year":"2022","journal-title":"World J Oncol"},{"key":"2026101422000410300_ref8","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/jso.26353","article-title":"Primary mesenteric sarcomas: collaborative experience from the trans-Atlantic Australasian retroperitoneal sarcoma working group (TARPSWG)","volume":"123","author":"Tattersall","year":"2021","journal-title":"J Surg Oncol"},{"key":"2026101422000410300_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.06.001","volume-title":"Int J Surg","author":"Garcia-Ortega","year":"2016"},{"key":"2026101422000410300_ref10","article-title":"The Diagnosis and Management of Retroperitoneal Sarcoma","volume":"32","author":"Dumitra","year":"2018","journal-title":"CancerNetwork"},{"key":"2026101422000410300_ref11","doi-asserted-by":"publisher","first-page":"6400","DOI":"10.3390\/curroncol29090504","article-title":"Updates in pathology for retroperitoneal soft tissue sarcoma","volume":"29","author":"Mack","year":"2022","journal-title":"Current Oncology"},{"key":"2026101422000410300_ref12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/modpathol.2008.164","article-title":"Primary retroperitoneal myxoid\/round cell liposarcoma is a nonexisting disease: an immunohistochemical and molecular biological analysis","volume":"22","author":"Vreeze","year":"2009","journal-title":"Mod Pathol"},{"key":"2026101422000410300_ref13","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1016\/j.radcr.2025.05.094","article-title":"A case report and literature review on a large MDM2 negative retroperitoneal\/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma","volume":"20","author":"Xie","year":"2025","journal-title":"Radiol Case Rep"}],"container-title":["Journal of Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag919\/71949082\/rjag919.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jscr\/article-pdf\/2026\/10\/rjag919\/71949082\/rjag919.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:00:09Z","timestamp":1792029609000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jscr\/article\/doi\/10.1093\/jscr\/rjag919\/8916696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jscr\/rjag919","relation":{},"ISSN":["2042-8812"],"issn-type":[{"value":"2042-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,10]]},"article-number":"rjag919"}}